Exercise-induced regulation of matrix metalloproteinases in the skeletal muscle of subjects with type 2 diabetes

This study examined whether exercise-induced regulation of MMPs is maintained in the skeletal muscle of patients with uncomplicated type 2 diabetes (T2DM). Subjects [12 T2DM, 9 healthy control subjects (CON)] underwent 8 weeks of physical training. Messenger RNA (mRNA) was measured at baseline, during and after 8 weeks of training. Protein was measured pre- and post-training. At baseline, there were no effects of diabetes on MMP or TIMP mRNA or protein. mRNA and protein response to training was similar in both groups, except active MMP-2 protein was elevated post training in T2DM only. Our results indicate that exercise-induced stimulation of MMPs is preserved in skeletal muscle of patients with T2DM. This early stage of diabetes may provide an opportunity for intervention and prevention of complications.

Source: Diabetes and Vascular Disease Research - August 12, 2014 Category: Endocrinology Authors: Scheede-Bergdahl, C., Bergdahl, A., Schjerling, P., Qvortrup, K., Koskinen, S. O., Dela, F. Tags: Original Articles Source Type: research