Issue Information
COVER PHOTOGRAPH: Stage 41. Early pre‐hatching. The tip of the tail extends over the head to the posterior of the eye. The iridocytes start to turn a brown‐orange color. A few small round teeth are visible on the jaws. There are 30‐32 cartilaginous vertebrae with neural and hemal arches forming. Ossification of the vertebrae and arches is underway. In the tail, the hypural plate cartilages are forming. From: Embryonic development of the annual killifish Austrofundulus limnaeus: An emerging model for ecological and evolutionary developmental biology research and instruction; Jason E. Podrabsky, Claire L. Riggs, Amie L...
Source: Developmental Dynamics - October 16, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Mesenchymal stromal cell engagement in cancer cell epithelial to mesenchymal transition
Due to coexistence of stromal and epithelial tumor cells, their dynamic interactions have been widely recognized as significant cellular components to the tumor tissue integrity. Initiation and outcome of epithelial to mesenchymal transition (EMT) in tumor cells are dependent on their interaction with adjacent or recruited mesenchymal stromal cells (MSCs). A plethora of mechanisms are involved in MSCs‐controlled employment of the developmental processes of EMT that contribute to loss of epithelial cell phenotype and acquisition of stemness, invasiveness and chemoresistance of tumor cells. Interplay of MSCs with tumor cel...
Source: Developmental Dynamics - October 4, 2017 Category: Molecular Biology Authors: Drenka Trivanovi ć, Jelena Krstić, Aleksandra Jauković, Diana Bugarski, Juan F. Santibanez Tags: Reviews Source Type: research
Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice
Conclusions: YS EMPs expressing mutant PTPN11 demonstrate functional and molecular features of JMML but do not cause disease following transplantation nor following unperturbed development. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - October 4, 2017 Category: Molecular Biology Authors: Stefan P. Tarnawsky, Momoko Yoshimoto, Lisa Deng, Rebecca J. Chan, Mervin C. Yoder Tags: Research Article Source Type: research
hace1 influences zebrafish cardiac development via ROS ‐dependent mechanisms
Conclusions: Our study demonstrates that HACE1 is critical in the normal development and proper function of the heart via a ROS‐dependent mechanism. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - October 1, 2017 Category: Molecular Biology Authors: Babak Razaghi, Shelby L. Steele, Sergey V. Prykhozhij, Matthew R. Stoyek, Jessica A. Hill, Matthew D. Cooper, Lindsay McDonald, William Lin, Mads Daugaard, Nicolas Crapoulet, Simi Chacko, Stephen Lewis, Ian C. Scott, Poul H.B. Sorensen, Jason N. Berman Tags: Research Article Source Type: research
ReMAPping the Microtubule Landscape: How Phosphorylation Dictates the Activities of Microtubule ‐Associated Proteins
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - October 1, 2017 Category: Molecular Biology Authors: Amrita Ramkumar, Brigette Y. Jong, Kassandra M. Ori ‐McKenney Tags: Reviews Source Type: research
Gut feelings: Studying enteric nervous system development, function and disease in the zebrafish model system
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - October 1, 2017 Category: Molecular Biology Authors: Julia Ganz Tags: Reviews Source Type: research
Prospects for new lung cancer treatments that target EMT signaling
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 27, 2017 Category: Molecular Biology Authors: Yuji Otsuki, Hideyuki Saya, Yoshimi Arima Tags: Reviews Source Type: research
Gene network underlying the glial regenerative response to central nervous system injury
Although the central nervous system does not regenerate, injury induces repair and regenerative responses in glial cells. In mammals, activated microglia clear up apoptotic cells and debris resulting from the injury, astrocytes form a scar that contains the lesion, and NG2‐glia elicit a prominent regenerative response. NG2‐glia regenerate themselves and differentiate into oligodendrocytes, which remyelinate axons leading to some recovery of locomotion. The regenerative response of glial cells is evolutionarily conserved across the animals and Drosophila genetics revealed an underlying gene network. This involves the ge...
Source: Developmental Dynamics - September 25, 2017 Category: Molecular Biology Authors: Kentaro Kato, Maria Losada ‐Perez, Alicia Hidalgo Tags: Reviews Source Type: research
Gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish
Conclusions: In zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra‐ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS), suggesting a role for a related TGFB signaling molecule in the etiology of PCOS. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 25, 2017 Category: Molecular Biology Authors: Yi ‐Lin Yan, Thomas Desvignes, Ruth Bremiller, Catherine Wilson, Danielle Dillon, Samantha High, Bruce Draper, Charles Loren Buck, John Postlethwait Tags: Research Article Source Type: research
Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects
Conclusions: Surprisingly, Sin3b is not essential in zebrafish. sin3b mutants show a decrease in fitness, small size, changes to locomotor behavior, and delayed bone development. We did not detect a role for Sin3b in cell proliferation. Our analysis of the sin3b mutant revealed a more nuanced requirement for zebrafish Sin3b than would be predicted from analysis of mutants in other species. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 25, 2017 Category: Molecular Biology Authors: Cara E. Moravec, Hakeem Yousef, Brian A. Kinney, Ryan Salerno ‐Eichenholz, Camillia M. Monestime, Benjamin L. Martin, Howard I. Sirotkin Tags: Research Article Source Type: research
Asymmetric development of the nervous system
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 23, 2017 Category: Molecular Biology Authors: Amel Alqadah, Yi ‐Wen Hsieh, Zachery D. Morrissey, Chiou‐Fen Chuang Tags: Reviews Source Type: research
Refuting the hypothesis that semaphorin ‐3f/neuropilin‐2 exclude blood vessels from the cap mesenchyme in the developing kidney
Conclusions: Despite their complementary expression patterns, our data suggest that Sema3f and Nrp2 are dispensable for the exclusion of vessels from the cap mesenchyme during kidney development. These results should provoke additional experiments to ascertain the biological significance of Sema3f/Nrp2 expression in the developing kidney. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 20, 2017 Category: Molecular Biology Authors: David A. D. Munro, Peter Hohenstein, Thomas M. Coate, Jamie A. Davies Tags: Patterns & Phenotypes Source Type: research
Issue Information
COVER PHOTOGRAPH: A single neural tube forms in tbx16 double mutants. Confocal projections of embryos labeled for acetylated tubulin (green), fast muscle (F310; red), and myosin heavy chain (A4.1025; blue) in dorsal view. From: tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis; Zachary T. Morrow, Adrienne M. Maxwell, Kazuyuki Hoshijima, Jared C. Talbot, David J. Grunwald, and Sharon L. Amacher. Developmental Dynamics 246:759–769. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 13, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Endothelial to mesenchymal transition in cardiovascular diseases: Developmental signalling pathways gone awry
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 11, 2017 Category: Molecular Biology Authors: Gonzalo S ánchez‐Duffhues, Amaya García de Vinuesa, Peter ten Dijke Tags: Reviews Source Type: research
Ventral neural patterning in the absence of a Shh activity gradient from the floorplate
CONCLUSIONS: The full range of neuronal progenitor types can be generated in the absence of a Shh gradient provided pathway repression is dampened, illustrating the complexity of morphogen dynamics in vertebrate patterning. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 11, 2017 Category: Molecular Biology Authors: Angelo Iulianella, Daisuke Sakai, Hiroshi Kurosaka, Paul Trainor Tags: Research Article Source Type: research
