Issue Information
COVER PHOTOGRAPH: Snapshot of a secondary septum during alveologenesis. From: Therapeutic and pathological roles of fibroblast growth factors in pulmonary diseases; Elie El Agha, Werner Seeger and Saverio Bellusci; Developmental Dynamics 246:235–244.
Read the full article at DOI: 10.1002/dvdy.24468 (Source: Developmental Dynamics)
Source: Developmental Dynamics - March 14, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
ETS transcription factor ETV2/ER71/Etsrp in hematopoietic and vascular development, injury, and regeneration
The major goal in regenerative medicine is to repair and restore injured, diseased or aged tissue function, thereby promoting general health. As such, the field of regenerative medicine has great translational potential in undertaking many of the health concerns and needs that we currently face. In particular, hematopoietic and vascular systems supply oxygen and nutrients and thus play critical roles in tissue development and tissue regeneration. Additionally, tissue vasculature serves as a tissue stem cell niche and thus contributes to tissue homeostasis. Notably, hematopoietic and vascular systems are sensitive to injury...
Source: Developmental Dynamics - March 1, 2017 Category: Molecular Biology Authors: Haiyong Zhao, Canxin Xu, Tae ‐Jin Lee, Fang Liu, Kyunghee Choi Tags: Review Source Type: research
MicroRNA ‐142 is a multifaceted regulator in organogenesis, homeostasis, and disease
Over the past decade, microRNA‐142 (miR‐142) is emerging as a major regulator of cell fate decision in the hematopoietic system. However, miR‐142 is expressed in many other tissues, and recent evidence suggests that it may play a more pleiotropic role during embryonic development. In addition, miR‐142 has been shown to play important functions in disease. miR‐142 displays a functional role in cancer, virus infection, inflammation, and immune tolerance. Both a guide strand (miR‐142‐3p) and passenger strand (miR‐142‐5p) are generated from the miR‐142 hairpin. miR‐142‐3p and ‐5p display overlapping b...
Source: Developmental Dynamics - March 1, 2017 Category: Molecular Biology Authors: Amit Shrestha, Regina T. Mukhametshina, Sara Taghizadeh, Esmeralda V ásquez‐Pacheco, Hector Cabrera‐Fuentes, Albert Rizvanov, Bernard Mari, Gianni Carraro, Saverio Bellusci Tags: Review Source Type: research
Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation
Conclusions: Drosophila Claspin plays a major role in the initiation and elongation stages of chorion gene amplification by localizing to the amplification foci in a mei‐41‐independent manner. Drosophila mus101 is also involved in chorion gene amplification, mostly functioning in initiation, rather than elongation. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - February 28, 2017 Category: Molecular Biology Authors: Seung Ho Choi, Ji ‐Hong Park, Tram Thi Ngoc Nguyen, Hee Jin Shim, Young‐Han Song Tags: Research Article Source Type: research
Recovery of shape and size in a developing organ pair
CONCLUSIONS
We propose that symmetry in developmental systems does not emerge through precise deterministic bilateral development, but rather through feedback mechanisms that adjust morphogenesis rates to account for variation. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - February 28, 2017 Category: Molecular Biology Authors: Amelia A. Green, Kishore R. Mosaliganti, Ian A. Swinburne, Nikolaus D. Obholzer, Sean G. Megason Tags: Research Article Source Type: research
