Adult functions for the Drosophila DHR78 nuclear receptor
Conclusions: This study provides a new context for linking the molecular activity of the TR orphan nuclear receptors with their complex roles in adult physiology and lifespan. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 24, 2017 Category: Molecular Biology Authors: Stefanie Marxreiter, Carl S. Thummel Tags: Research Article Source Type: research
Lacrimal gland development: From signaling interactions to regenerative medicine
The lacrimal gland plays a pivotal role in keeping the ocular surface lubricated, and protecting it from environmental exposure and insult. Dysfunction of the lacrimal gland results in deficiency of the aqueous component of the tear film, which can cause dryness of the ocular surface, also known as the aqueous ‐deficient dry eye disease. Left untreated, this disease can lead to significant morbidity, including frequent eye infections, corneal ulcerations, and vision loss. Current therapies do not treat the underlying deficiency of the lacrimal gland, but merely provide symptomatic relief. To develop mor e sustainable and...
Source: Developmental Dynamics - November 16, 2017 Category: Molecular Biology Authors: Ankur Garg,
Xin Zhang Tags: Review Source Type: research
Transitions
(Source: Developmental Dynamics)
Source: Developmental Dynamics - November 16, 2017 Category: Molecular Biology Authors: Parker B. Antin Tags: Editorial Source Type: research
Issue Information
COVER PHOTOGRAPH: Expression of eGFP reporter gene in adult mustn1b:eGFP transgenic zebrafish. A transverse section of the head shows marked eGFP fluorescence in muscle tissue including jaw and cranial muscles, tongue, and heart; From: Promoter architecture and transcriptional regulation of musculoskeletal embryonic nuclear protein 1b (mustn1b) gene in zebrafish; Paula Suarez‐Bregua, Chien‐ju Chien, Manuel Megias, Shaojun Du, and Josep Rotllant; Developmental Dynamics 246:992–1000. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 16, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina
Developmental Dynamics,Volume 247, Issue 4, Page 630-641, April 2018. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 15, 2017 Category: Molecular Biology Source Type: research
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Developmental Dynamics,Volume 247, Issue 4, Page 630-641, April 2018. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 15, 2017 Category: Molecular Biology Source Type: research
The zinc finger gene Nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina
Conclusions: We conclude that Nolz1 has multiple functions during development and suggest a mechanism in which Nolz1 initially regulates the proliferation state of the retinal progenitor cells and then acts as a repressor that suppresses the Lim3/Lhx3 bipolar cell phenotype at the time of bipolar cell differentiation. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 15, 2017 Category: Molecular Biology Authors: Maria K.E. Blixt, Dardan Konjusha, Henrik Ring, Finn Hallb öök Tags: Research Article Source Type: research
Animal models of Fibrodysplasia Ossificans Progressiva
(Source: Developmental Dynamics)
Source: Developmental Dynamics - November 1, 2017 Category: Molecular Biology Authors: Melissa LaBonty, Pamela C. Yelick Tags: Reviews Source Type: research
Pten regulates neural crest proliferation and differentiation during mouse craniofacial development
Conclusions
Our study revealed that Pten is essential for craniofacial morphogenesis in mice. Inactivating Pten in neural crest cells increases proliferation rate and promotes their differentiation towards osteoblasts. Our data further indicate that Pten acts via modulating PI3K/AKT activity during these processes. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 1, 2017 Category: Molecular Biology Authors: Tianfang Yang, Matthew Moore, Fenglei He Tags: Research Article Source Type: research
Regulation of continuous but complex expression pattern of Six1 during early sensory development
Conclusions: mSix1‐21‐NLSCre has several unique characteristics to make it suitable for analysis of cell lineage and gene function in sensory placodes as well as non‐placodal Six1‐positive structures. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 1, 2017 Category: Molecular Biology Authors: Shigeru Sato, Yasuhide Furuta, Kiyoshi Kawakami Tags: Patterns & Phenotypes Source Type: research
Characterization of Calbindin D28k Expressing Interneurons in the Ventral Horn of the Mouse Spinal Cord
Conclusions: These findings suggest CB labels a heterogeneous group of interneurons in the ventral horn, some of which may process sensory information. Based on cellular position, CB expression may be a shared feature of subsets of interneurons arising from multiple ventral progenitor domains. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - November 1, 2017 Category: Molecular Biology Authors: Taylor L. Floyd, Yiyun Dai, David R. Ladle Tags: Research Article Source Type: research
Endothelial ‐to‐mesenchymal transition in cardiovascular diseases: Developmental signaling pathways gone awry
The process named endothelial‐to‐mesenchymal transition (EndMT) was observed for the first time during the development of the chicken embryo several decades ago. Of interest, accumulating evidence suggests that EndMT plays a critical role in the onset and progression of multiple postnatal cardiovascular diseases. EndMT is controlled by a set of developmental signaling pathways, very similar to the process of epithelial‐to‐mesenchymal transition, which determine the activity of several EndMT transcriptional effectors. Once activated, these EndMT effectors regulate the expression of endothelial‐ and mesenchymal‐s...
Source: Developmental Dynamics - October 25, 2017 Category: Molecular Biology Authors: Gonzalo S ánchez‐Duffhues, Amaya García de Vinuesa, Peter Dijke Tags: Reviews Source Type: research
Gut feelings: Studying enteric nervous system development, function, and disease in the zebrafish model system
Abstract
The enteric nervous system (ENS) is the largest part of the peripheral nervous system and is entirely neural crest–derived. It provides the intrinsic innervation of the gut, controlling different aspects of gut function, such as motility. In this review, we will discuss key points of Zebrafish ENS development, genes, and signaling pathways regulating ENS development, as well as contributions of the Zebrafish model system to better understand ENS disorders. During their migration, enteric progenitor cells (EPCs) display a gradient of developmental states based on their proliferative and migratory characteristics,...
Source: Developmental Dynamics - October 23, 2017 Category: Molecular Biology Authors: Julia Ganz Tags: Reviews Source Type: research
Zebrafish as models for developmental disease & repair
(Source: Developmental Dynamics)
Source: Developmental Dynamics - October 16, 2017 Category: Molecular Biology Authors: Robert Cornell, Richard I. Dorsky Tags: Editorial Source Type: research
Annual killifishes as model systems for advancing understanding of evolution and developmental biology
(Source: Developmental Dynamics)
Source: Developmental Dynamics - October 16, 2017 Category: Molecular Biology Authors: Jason E. Podrabsky, Mar ía Arezo Tags: Editorial Source Type: research
