Pten regulates neural crest proliferation and differentiation during mouse craniofacial development

Conclusions Our study revealed that Pten is essential for craniofacial morphogenesis in mice. Inactivating Pten in neural crest cells increases proliferation rate and promotes their differentiation towards osteoblasts. Our data further indicate that Pten acts via modulating PI3K/AKT activity during these processes. This article is protected by copyright. All rights reserved.
Source: Developmental Dynamics - Category: Molecular Biology Authors: Tags: Research Article Source Type: research