Xenopus pitx3 target genes lhx1 and xnr5 are identified using a novel three ‐fluor flow cytometry‐based analysis of promoter activation and repression
Conclusions: We demonstrate how flow cytometry can be used to detect gene regulatory changes with exquisite precision on a cell‐by‐cell basis, and establish that in HEK293 cells, pitx3 directly activates lhx1 and represses xnr5. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - June 9, 2017 Category: Molecular Biology Authors: Lara N. Hooker, Cristine Smoczer, Samuel Abbott, Mohamad Fakhereddin, John W. Hudson, Michael J. Crawford Tags: Research Article Source Type: research
The role of energetic reserves during embryonic development of an annual killifish
Conclusions: These findings suggest uncoupling of the two traits examined, i.e. embryonic energetic reserves and development duration, and emphasize the strong buffering role of diapause in the energetic balance of embryonic development in the annual killifish. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - June 9, 2017 Category: Molecular Biology Authors: Milan Vrt ílek, Matej Polačik, Martin Reichard Tags: Research Article Source Type: research
Morphological and molecular evolution of the ultimobranchial gland of non ‐mammalian vertebrates, with special reference to the chicken C cells
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - June 1, 2017 Category: Molecular Biology Authors: Yoko Kameda Tags: Reviews Source Type: research
Conserved signaling mechanisms in Drosophila heart development
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - June 1, 2017 Category: Molecular Biology Authors: Shaad M. Ahmad Tags: Reviews Source Type: research
Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin
Conclusions: We conclude that Cx43 activity in the dermal fibroblasts influences the expression of evx1, and therefore the differentiation of the precursor cells that give rise to the joint‐forming osteoblasts. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - June 1, 2017 Category: Molecular Biology Authors: Gabrielle Dardis, Robert Tryon, Quynh Ton, Stephen L. Johnson, M. Kathryn Iovine Tags: Patterns & Phenotypes Source Type: research
The murine lens: A model to investigate in vivo epithelial –mesenchymal transition
Epithelial–mesenchymal transition (EMT) produces myofibroblasts that contribute to the formation of fibrotic tissue with an impairment of tissue homeostasis and functionality. The crystalline lens of the eye is a unique transparent and isolated tissue. The lens vesicle becomes isolated from the surface ectoderm, its cells are all contained as they line the inner surface of the lens capsule. Clinically the formation of fibrotic tissue by the lens epithelial cells causes a type of cataract or opacification and contraction of the lens capsule postcataract surgery. Production of EMT in the intact animal lens by using specifi...
Source: Developmental Dynamics - June 1, 2017 Category: Molecular Biology Authors: Kumi Shirai, Sai ‐ichi Tanaka, Frank J. Lovicu, Shizuya Saika Tags: Reviews Source Type: research
Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells
Conclusion: Wnt2B co‐operates with Frizzled7 to mediate MET in colorectal cancer. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 31, 2017 Category: Molecular Biology Authors: Renate H. M. Schwab, Nancy Amin, Dustin J. Flanagan, Timothy M. Johanson, Toby J. Phesse, Elizabeth Vincan Tags: Research Article Source Type: research
Suppressor of Fused Controls Cerebellar Neuronal Differentiation in a Manner Modulated by GLI3 Repressor and Fgf15
CONCLUSIONS: Together, our results show that SuFu promotes cerebellar radial precursor differentiation to neurons. SuFu function is mediated in part by GLI3R and down‐regulation of Fgf15 expression. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 30, 2017 Category: Molecular Biology Authors: Jinny J. Kim, Tayyaba Jiwani, Steven Erwood, Jillian Loree, Norman D. Rosenblum Tags: Research Article Source Type: research
Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms
Conclusions: RPE development to produce the monolayer epithelium that covers the back of the neural retina occurs in two distinct phases driven by distinct mechanisms. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 27, 2017 Category: Molecular Biology Authors: Paula Bernice Cechmanek, Sarah McFarlane, Nadean Brown Tags: Research Article Source Type: research
A Role for Primary Cilia in Aortic Valve Development and Disease
Conclusions: Our data support cilia as a novel cellular mechanism for restraining ECM production during aortic valve development and broadly implicate these structures in the etiology of BAV disease in humans. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 27, 2017 Category: Molecular Biology Authors: Katelynn A Toomer, Diana Fulmer, Lilong Guo, Alex Drohan, Neal Peterson, Paige Swanson, Brittany Brooks, Rupak Mukherjee, Simon Body, Josh Lipschutz, Andy Wessels, Russell A. Norris Tags: Patterns & Phenotypes Source Type: research
Epithelial –mesenchymal plasticity and circulating tumor cells: Travel companions to metastases
Epithelial–mesenchymal transitions (EMTs) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread. Understanding how EMT may functionally equip circulating tumor cells (CTCs) with an enhanced competence to survive in the bloodstream and niche in the colonized organs has thus become a major cancer research axis. We summarize here clinical data with CTC endpoints involving EMT. We then review the work funct...
Source: Developmental Dynamics - May 26, 2017 Category: Molecular Biology Authors: Marie ‐Emilie Francart, Justine Lambert, Aline M. Vanwynsberghe, Erik W. Thompson, Morgane Bourcy, Myriam Polette, Christine Gilles Tags: Reviews Source Type: research
The RNA ‐binding protein Caper is required for sensory neuron development in Drosophila melanogaster
Conclusions: Our results provide the first evidence for a fundamental and broad requirement for the highly conserved splicing factor Caper in the development and maintenance of the nervous system and provide a framework for future studies on the detailed mechanism of Caper mediated RNA regulation. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 23, 2017 Category: Molecular Biology Authors: Eugenia C. Olesnicky, Jeremy M. Bono, Laura Bell, Logan T. Schachtner, Meghan C. Lybecker Tags: Patterns & Phenotypes Source Type: research
Neurodegeneration in Ataxia ‐Telangiectasia: Multiple Roles of ATM Kinase in Cellular Homeostasis
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 23, 2017 Category: Molecular Biology Authors: Kay Rui Choy, Dianne J. Watters Tags: Reviews Source Type: research
Bud detachment in hydra requires activation of fibroblast growth factor receptor and a Rho –ROCK–myosin II signaling pathway to ensure formation of a basal constriction
Conclusions: Our data suggest an essential role of FGFR and a Rho‐ROCK‐myosin II pathway in the control of cell shape changes required for bud detachment. Developmental Dynamics, 2017. © 2017 The Authors Developmental Dynamics published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 22, 2017 Category: Molecular Biology Authors: Oliver Holz, David Apel, Patrick Steinmetz, Ellen Lange, Simon Hopfenm üller, Kerstin Ohler, Stefanie Sudhop, Monika Hassel Tags: Research Article Source Type: research
Endocardial fibroelastosis is secondary to hemodynamic alterations in the chick embryonic model of hypoplastic left heart syndrome
Conclusions: Abnormal hemodynamic loading during heart development leads to myocardial hypoxia, stimulating collagen production in the subendocardium. Therefore, EFE in this chick embryonic model of HLHS appears to be a secondary effect of abnormal hemodynamics. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - May 20, 2017 Category: Molecular Biology Authors: Zivorad Pesevski, Alena Kvasilova, Tereza Stopkova, Ondrej Nanka, Eliska Drobna Krejci, Christine Buffinton, Radka Kockova, Adam Eckhardt, David Sedmera Tags: Research Article Source Type: research
