Epithelial –mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease
Epithelial–mesenchymal transition (EMT) plays key roles during lung development and many lung diseases such as chronic obstructive pulmonary disease (COPD), lung cancer, and pulmonary fibrosis. Here, integrating morphological observations with underlying molecular mechanisms, we highlight the functional role of EMT in lung development and injury repair, and discuss how it can contribute to pathogenesis of chronic lung disease. We discuss the evidence of manifestation of EMT and its potential driving role in COPD, idiopathic pulmonary fibrosis (IPF), bronchiolitis obliterans syndrome (BOS), and lung cancer, while noting t...
Source: Developmental Dynamics - July 21, 2017 Category: Molecular Biology Authors: Mohit Kumar Jolly, Chris Ward, Mathew Suji Eapen, Stephen Myers, Oskar Hallgren, Herbert Levine, Sukhwinder Singh Sohal Tags: Review Source Type: research
Transforming Growth Factor ‐beta, Matrix Metalloproteinases and Urokinase‐Type Plasminogen Activator Interaction in the Cancer Epithelial to Mesenchymal Transition
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 19, 2017 Category: Molecular Biology Authors: Juan F. Santibanez, Hristina Obradovi ć, Tamara Kukolj, Jelena Krstić Tags: Reviews Source Type: research
Maximizing functional axon repair in the injured central nervous system: Lessons from neuronal development
The failure of damaged axons to regrow underlies disability in central nervous system injury and disease. Therapies that stimulate axon repair will be critical to restore function. Extensive axon regeneration can be induced by manipulation of oncogenes and tumor suppressors; however, it has been difficult to translate this into functional recovery in models of spinal cord injury. The current challenge is to maximize the functional integration of regenerating axons to recover motor and sensory behaviors. Insights into axonal growth and wiring during nervous system development are helping guide new approaches to boost regene...
Source: Developmental Dynamics - July 19, 2017 Category: Molecular Biology Authors: Andrew Kaplan, Mardja Bueno, Luyang Hua, Alyson E. Fournier Tags: Critical Commentaries Source Type: research
Runx2 ‐I is an Early Regulator of Epithelial–Mesenchymal Cell Transition in the Chick Embryo
Conclusions: These data introduce the RUNX2‐I isoform as a critical early transcription factor mediating EMT in the developing heart after induction by TGFβ2. Its expression in tumor tissue suggests a similar role for RUNX2 in the EMT of metastasis. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 19, 2017 Category: Molecular Biology Authors: Andre L.P. Tavares, Jessie A. Brown, Emily C. Ulrich, Katerina Dvorak, Raymond B. Runyan Tags: Research Article Source Type: research
Cellular glycosylation senses metabolic changes and modulates cell plasticity during EMT
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 19, 2017 Category: Molecular Biology Authors: P Carvalho ‐Cruz, F Alisson‐Silva, AR Todeschini, WB Dias Tags: Reviews Source Type: research
Putative binding sites for mir ‐125 family miRNAs in the mouse Lfng 3'UTR affect transcript expression in the segmentation clock, but mir‐125a‐5p is dispensable for normal somitogenesis
Conclusions: These results suggest that mir‐125a sites in the Lfng 3'UTR influence transcript turnover in both mouse and chicken embryos, and support the existence of position‐dependent regulatory mechanisms in the PSM. They further suggest the existence of compensatory mechanisms that can rescue the loss of mir‐125a‐5p in mice. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 15, 2017 Category: Molecular Biology Authors: Kanu Wahi, Sophia Friesen, Vincenzo Coppola, Susan E. Cole Tags: Research Article Source Type: research
Insights from zebrafish on human pigment cell disease and treatment
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 14, 2017 Category: Molecular Biology Authors: Cynthia D. Cooper Tags: Reviews Source Type: research
Lacrimal gland development: from signaling interactions to regenerative medicine
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 14, 2017 Category: Molecular Biology Authors: Ankur Garg, Xin Zhang Tags: Reviews Source Type: research
Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait
Developmental Dynamics,Volume 247, Issue 4, Page 620-629, April 2018. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 10, 2017 Category: Molecular Biology Source Type: research
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Developmental Dynamics,Volume 247, Issue 4, Page 620-629, April 2018. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 10, 2017 Category: Molecular Biology Source Type: research
Issue Information
COVER PHOTOGRAPH: Correlation of primary cilia with versican expressing microenvironments: High magnification images of axonemes (green) and collagen/versican (red). From: A Role for Primary Cilia in Aortic Valve Development and Disease; Katelynn A. Toomer, Diana Fulmer, Lilong Guo, Alex Drohan, Neal Peterson, Paige Swanson, Brittany Brooks, Rupak Mukherjee, Simon Body, Josh Lipschutz, Andy Wessels and Russell A. Norris; Developmental Dynamics: 246:625–634. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 10, 2017 Category: Molecular Biology Tags: Issue Information Source Type: research
Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait
Conclusion: Dcc plays a role in the development of local spinal networks to ensure proper lateralization of motor control during locomotion. Local spinal cord defects following loss of Dcc cause a hopping gait in mice and may contribute to MM in humans. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 10, 2017 Category: Molecular Biology Authors: Jimmy Peng, Julien Ferent, Qingyu Li, Mingwei Liu, Ronan Vinicius da Silva, Hanns Ulrich Zeilhofer, Artur Kania, Ying Zhang, Fr édéric Charron Tags: Research Article Source Type: research
tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis
Conclusion: These data demonstrate that tbx6l and tbx16 genes function redundantly to direct tail somite development. tbx6l single mutants develop normally because tbx16 fully compensates for loss of tbx6l function. However, tbx6l only partially compensates for loss of tbx16 function. These results resolve the question of why loss of function of tbx16 gene, which is expressed throughout the ventral and paraxial mesoderm, profoundly affects somite development in the trunk but not the tail. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 10, 2017 Category: Molecular Biology Authors: Zachary T. Morrow, Adrienne M. Maxwell, Kazuyuki Hoshijima, Jared C. Talbot, David J. Grunwald, Sharon L. Amacher Tags: Patterns & Phenotypes Source Type: research
Specification of neurotransmitter identity by Tal1 in thalamic nuclei
Conclusions: Our results demonstrate that Tal1 plays an essential role in regulating neurotransmitter phenotype in the developing thalamic nuclei. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 7, 2017 Category: Molecular Biology Authors: Bumwhee Lee, Myungsin Lee, Somang Song, Linh Duc Loi, Duc Tri Lam, Jaeseung Yoon, Kwanghee Baek, David J. Curtis, Yongsu Jeong Tags: Patterns & Phenotypes Source Type: research
MRTFs ‐ master regulators of EMT
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - July 6, 2017 Category: Molecular Biology Authors: Ákos Gasparics, Attila Sebe Tags: Reviews Source Type: research
