tbx6l and tbx16 are redundantly required for posterior paraxial mesoderm formation during zebrafish embryogenesis

Conclusion: These data demonstrate that tbx6l and tbx16 genes function redundantly to direct tail somite development. tbx6l single mutants develop normally because tbx16 fully compensates for loss of tbx6l function. However, tbx6l only partially compensates for loss of tbx16 function. These results resolve the question of why loss of function of tbx16 gene, which is expressed throughout the ventral and paraxial mesoderm, profoundly affects somite development in the trunk but not the tail. This article is protected by copyright. All rights reserved.

Source: Developmental Dynamics - July 10, 2017 Category: Molecular Biology Authors: Zachary T. Morrow, Adrienne M. Maxwell, Kazuyuki Hoshijima, Jared C. Talbot, David J. Grunwald, Sharon L. Amacher Tags: Patterns & Phenotypes Source Type: research