Mutations in the Katnb1 gene cause left –right asymmetry and heart defects
Conclusions: Katanin function is a critical regulator of heart development in mice. These findings are potentially relevant to human cardiac development. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 5, 2017 Category: Molecular Biology Authors: Milena B. Furtado, D. Jo Merriner, Silke Berger, Danielle Rhodes, Duangporn Jamsai, Moira K. O'Bryan Tags: Patterns & Phenotypes Source Type: research
Promoter architecture and transcriptional regulation of musculoskeletal embryonic nuclear protein 1b (mustn1b) gene in zebrafish
Conclusions: Our data indicates that mustn1b is specifically expressed in skeletal and cardiac muscle tissues and its muscle specificity is controlled by the 0.2 kb promoter and flanking sequences and in vivo regulated by the action of two sequence‐specific families of transcription factors (TFs). This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 1, 2017 Category: Molecular Biology Authors: P Suarez ‐Bregua, CJ Chien, M Megias, SD Du, J Rotllant Tags: Research Article Source Type: research
Removing vessel constriction on the embryonic heart results in changes in valve gene expression, morphology, and hemodynamics
Conclusions: Although some aspects of the genetic/cellular profiles affected by altered hemodynamics seem to be reversed, not all gene expression and cardiac growth normalize following 48 hr of band removal. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 1, 2017 Category: Molecular Biology Authors: Vinal Menon, John Eberth, Lorain Junor, Alexander J. Potts, Marwa Belhaj, Donald J. DiPette, Michael Jenkins, Jay D. Potts Tags: Research Article Source Type: research
Asymmetries in leaf branch are associated with differential speeds along growth axes: A theoretical prediction
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - September 1, 2017 Category: Molecular Biology Authors: Akiko Nakamasu, Nobuhiko J. Suematsu, Seisuke Kimura Tags: Research Article Source Type: research
Single nucleotide editing without DNA cleavage using CRISPR/Cas9 ‐deaminase in the sea urchin embryo
Conclusion: These results suggest that the Cas9‐DA approach may be useful for manipulating gene activity with decreased risks of genomic aberrations. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 31, 2017 Category: Molecular Biology Authors: Saba Shevidi, Alicia Uchida, Natalie Schudrowitz, Gary M. Wessel, Mamiko Yajima Tags: Patterns & Phenotypes Source Type: research
The Fly Eye: Through the Looking Glass
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 30, 2017 Category: Molecular Biology Authors: Justin P. Kumar Tags: Reviews Source Type: research
The gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish
Conclusions: In zebrafish, gsdf regulates ovarian follicle maturation and expression of genes for steroid biosynthesis, obesity, diabetes, and female fertility, leading to ovarian and extra‐ovarian phenotypes that mimic human polycystic ovarian syndrome (PCOS), suggesting a role for a related TGFB signaling molecule in the etiology of PCOS. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 30, 2017 Category: Molecular Biology Authors: Yi ‐Lin Yan, Thomas Desvignes, Ruth BreMiller, Catherine Wilson, Danielle Dillon, Samantha High, Bruce Draper, Charles Loren Buck, John Postlethwait Tags: Research Article Source Type: research
Role of the extracellular matrix in cancer ‐associated epithelial to mesenchymal transition phenomenon
The epithelial to mesenchymal transition (EMT) program is a crucial component in the processes of morphogenesis and embryonic development. The transition of epithelial to mesenchymal phenotype is associated with numerous structural and functional changes, including loss of cell polarity and tight cell–cell junctions, the acquisition of invasive abilities, and the expression of mesenchymal proteins. The switch between the two phenotypes is involved in human pathology and is crucial for cancer progression. Extracellular matrices (ECMs) are multi‐component networks that surround cells in tissues. These networks are obliga...
Source: Developmental Dynamics - August 30, 2017 Category: Molecular Biology Authors: George Tzanakakis, Rafaela ‐Maria Kavasi, Kallirroi Voudouri, Aikaterini Berdiaki, Ioanna Spyridaki, Aristidis Tsatsakis, Dragana Nikitovic Tags: Review Source Type: research
Annual killifish adaptations to ephemeral environments: Diapause I in two Austrolebias species
Conclusion: These phenotypes are alternative diapause I stages, and may have ecological relevance since both were found in embryos in natural ponds. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 29, 2017 Category: Molecular Biology Authors: Mar ía José Arezo, Nicolás G. Papa, Nibia Berois, Graciela Clivio, Jimena Montagne, Soledad De la Piedra Tags: Patterns & Phenotypes Source Type: research
MicroRNA ‐induced silencing in epilepsy: Opportunities and challenges for clinical application
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 29, 2017 Category: Molecular Biology Authors: Durgesh Tiwari, Katrina Peariso, Christina Gross Tags: Reviews Source Type: research
Zebrafish sin3b mutants are viable but have size, skeletal and locomotor defects
Conclusion: Surprisingly, Sin3b is not essential in zebrafish. sin3b mutants show a decrease in fitness, small size, changes to locomotor behavior, and delayed bone development. We did not detect a role for Sin3b in cell proliferation. Our analysis of the sin3b mutant revealed a more nuanced requirement for zebrafish Sin3b than would be predicted from analysis of mutants in other species. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 29, 2017 Category: Molecular Biology Authors: Cara E. Moravec, Hakeem Yousef, Brian A. Kinney, Ryan Salerno ‐Eichenholz, Camillia Monestime, Benjamin L. Martin, Howard I. Sirotkin Tags: Research Article Source Type: research
Expression of genes and proteins of the Pax ‐Six‐Eya‐Dach network in the metamorphic sea urchin: insights into development of the enigmatic echinoderm body plan and sensory structures
Conclusion: Our results support roles for PSEDN genes in development of the pentameral body plan, contributing to our understanding of how the most unusual body plan in the Bilateria may have evolved. Development of sensory cells within the Pax‐Six expression field is consistent with the role of these genes in sensory cell development in diverse species. This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 29, 2017 Category: Molecular Biology Authors: Maria Byrne, Demian Koop, Valerie B. Morris, Juanita Chui, Gregory A. Wray, Paula Cisternas Tags: Patterns & Phenotypes Source Type: research
“Mesenchymal Stromal Cell Engagement in Cancer Cell Epithelial to Mesenchymal Transition”
This article is protected by copyright. All rights reserved. (Source: Developmental Dynamics)
Source: Developmental Dynamics - August 29, 2017 Category: Molecular Biology Authors: Drenka Trivanovi ć, Jelena Krstić, Aleksandra Jauković, Diana Bugarski, Juan F. Santibanez Tags: Reviews Source Type: research
Transforming growth factor ‐β, matrix metalloproteinases, and urokinase‐type plasminogen activator interaction in the cancer epithelial to mesenchymal transition
Transforming growth factor‐β (TGF‐β) is a pleiotropic factor that acts as a tumor suppressor in the early stages, while it exerts tumor promoting activities in advanced stages of cancer development. One of the hallmarks of cancer progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. Matrix metalloproteinases (MMPs) together with urokinase‐type plasminogen activator (uPA) and its receptor (uPAR), whose main original function described is the proteolytic degradation of the extracellular matrix, play key cellular roles in the enhancement o...
Source: Developmental Dynamics - August 24, 2017 Category: Molecular Biology Authors: Juan F. Santibanez, Hristina Obradovi ć, Tamara Kukolj, Jelena Krstić Tags: Reviews Source Type: research
Morphological and molecular evolution of the ultimobranchial gland of nonmammalian vertebrates, with special reference to the chicken C cells
This review summarizes the current understanding of the nonmammalian ultimobranchial gland from morphological and molecular perspectives. Ultimobranchial anlage of all animal species develops from the last pharyngeal pouch. The genes involved in the development of pharyngeal pouches are well conserved across vertebrates. The ultimobranchial anlage of nonmammalian vertebrates and monotremes does not merge with the thyroid, remaining as an independent organ throughout adulthood. Although C cells of all animal species secrete calcitonin, the shape, cellular components and location of the ultimobranchial gland vary from specie...
Source: Developmental Dynamics - August 24, 2017 Category: Molecular Biology Authors: Yoko Kameda Tags: Reviews Source Type: research
