Zebrafish sin3b mutants are viable but have size, skeletal and locomotor defects

Conclusion: Surprisingly, Sin3b is not essential in zebrafish. sin3b mutants show a decrease in fitness, small size, changes to locomotor behavior, and delayed bone development. We did not detect a role for Sin3b in cell proliferation. Our analysis of the sin3b mutant revealed a more nuanced requirement for zebrafish Sin3b than would be predicted from analysis of mutants in other species. This article is protected by copyright. All rights reserved.
Source: Developmental Dynamics - Category: Molecular Biology Authors: Tags: Research Article Source Type: research