Zebrafish sin3b mutants are viable but have size, skeletal, and locomotor defects

Conclusions: Surprisingly, Sin3b is not essential in zebrafish. sin3b mutants show a decrease in fitness, small size, changes to locomotor behavior, and delayed bone development. We did not detect a role for Sin3b in cell proliferation. Our analysis of the sin3b mutant revealed a more nuanced requirement for zebrafish Sin3b than would be predicted from analysis of mutants in other species. Developmental Dynamics, 2017. © 2017 Wiley Periodicals, Inc.
Source: Developmental Dynamics - Category: Molecular Biology Authors: Tags: Research Article Source Type: research