A pilot study of esophageal motility and rikkunshito treatment for proton pump inhibitor-refractory non-erosive reflux disease: A prospective, uncontrolled, open-label trial
Conclusions In the pilot study, PPI- refractory NERD patients had with disorders of esophageal and LES motility were improved by RKT. Further studies examining esophageal motor activity of RKT in PPI-refractory NERD are required. UMIN Clinical Trial Registry identifier: UMIN000003092. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
Multi-center prospective observational study of bleeding risk related to upper gastrointestinal endoscopic biopsy in patients receiving antithrombotic therapy
Conclusion We found no significant increase in upper GI bleeding risk following an EGD biopsy in patients taking antithrombotic agents, suggesting its safety without the need for antithrombotic treatment interruption. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
Diagnosis and Treatment of Autoimmune Liver Diseases in a Tertiary Referral Center in Cuba
Conclusion The clinical profile of AILD in a sample of the Cuban population is similar to that reported in South areas. AIH was more frequent than PBC, and usually presented with advanced liver disease that responded poorly to treatment. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
A Prospective, Open, Uncontrolled, Non-Randomized, Observational study of Curative Metatarsal Bone Surgery Combined With Intralesional Administration of Rh-Egf in Diabetic Neuropathic Ulceration of the Forefoot
Conclusion The combination of curative metatarsal bone surgery with intralesional administration of recombinant human epidermal growth factor resulted in a significant reduction in the re-epithelization time, recidivism and development of new diabetic lesions. The safety profile was appropriate. However, more randomized, triple blind, and placebo trials are needed to evaluate the efficacy and safety of this new therapy. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
A Bayesian Approach for Population Pharmacokinetic Modeling of Alcohol in Japanese Subjects
Conclusions A population pharmacokinetic model for alcohol was updated. A Bayesian approach allowed interpretation of significant covariate relationships, even if the current dataset is not informative about all parameters. This is the first study reporting an estimate of the effect of the ALDH2 genotype in a PPK model. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor, Sitagliptin on Atherosclerosis, Beta-Cell Function and Glycemic Control in Japanese Patients with Type 2 Diabetes Mellitus Who are Treatment Na ïve or Poorly Responsive to Anti-Diabetic Agents (Sitagliptin INvestigation on GLycemic Effects in Yokohama: SINGLE-Y): A Multicenter, Prospective Observational, Uncontrolled Study
Conclusions Sitagliptin may have beneficial effects on vascular inflammation and beta cell function in Japanese patients with type 2 diabetes. Pentraxin-3 may be an early predictive marker for detecting the anti-atherosclerotic effects of DPP-4 inhibitors. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 9, 2017 Category: Drugs & Pharmacology Source Type: research
Chemical Stability of Ceftolozane/Tazobactam in Polyvinylchloride Bags and Elastomeric Pumps
Conclusions Ceftolozane/tazobactam remains physically and chemically stable for at least 7 days, as indicated in the US label, when reconstituted, diluted, and stored in the AccuFlo and I-Flow Homepump Eclipse elastomeric pumps and in PVC IV bags. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 6, 2017 Category: Drugs & Pharmacology Source Type: research
Roads to Health in developing countries – Understanding the intersection of culture and healing
Publication date: Available online 4 March 2017 Source:Current Therapeutic Research Author(s): S. Ibeneme, G. Eni, A. Ezuma, G. Fortwengel The most important attribute for which all human beings aspire is good health because it enables man to undertake different forms of activities of daily living. The emergence of scientific knowledge in Western Societies has enabled scientists to explore and define several parameters of "health" by drawing boundaries around factors that are known to impact on the achievement of good health. For example, the World Health Organization [WHO] defined health by taking physical and psych...
Source: Current Therapeutic Research - March 4, 2017 Category: Drugs & Pharmacology Source Type: research
Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study
Conclusions The V and half-life of amikacin in this cohort varied from that reported in non-African populations, and the high trough and low peak amikacin concentrations in both term and preterm neonates suggest strategies to optimize amikacin dosing are required in this population. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 10, 2017 Category: Drugs & Pharmacology Source Type: research
Challenges of Empirical Antibiotic Therapy for Community-Acquired Pneumonia in Children
Conclusions Effective and timely treatment is required for CAP and empirical antibiotics are evidence-based and appropriate in most settings. However, better diagnostics and education to target treatment may help to prevent antibiotic resistance. Ensuring the secure financing of clean food and water, sanitation, and public health infrastructure are also required to reduce the burden of disease in children in developing countries. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 6, 2017 Category: Drugs & Pharmacology Source Type: research
Repurposed Therapeutic Agents Targeting the Ebola Virus: A Systematic Review
Conclusions Several established drugs may have potential therapeutic effects on EVD, but the quality and quantity of current scientific evidence is lacking. This review highlights the need for well-designed and conducted preclinical and clinical research to establish the efficacy of potential repurposed drugs against EVD. Systematic review registration PROSPERO CRD42015024349 (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 2, 2017 Category: Drugs & Pharmacology Source Type: research
A Case Series of Liver Abscess Formation after Transcatheter Arterial Chemoembolization for Hepatic Tumors
Conclusions TACE must be implemented with extreme caution to avoid liver abscess, especially for hepatic tumors larger in size and for lesions close to the gallbladder. Despite its low incidence, liver abscess after TACE can cause serious consequences. Effective treatment requires early diagnosis, timely use of sufficient doses of appropriate antibiotics, and proper implementation of abscess incision, drainage and aspiration. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - February 2, 2017 Category: Drugs & Pharmacology Source Type: research
Safety, Efficacy and Bioavailability of Fixed Dose Combinations in Type 2 Diabetes Mellitus: A Systematic Updated Review
Publication date: Available online 2 February 2017 Source:Current Therapeutic Research Author(s): Thangavel Mahalingam Vijayakumar, Jayasutha Jayaram, Vishnu Meghana Cheekireddy, Dasari Himaja, Yalamanchili Dharma Teja, Damodharan Narayanasamy Purpose Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance. As time progresses, monotherapy often does not provide effective glycemic control generating the need for an add-on therapy. Hence, multiple oral hypoglycemic agents formulated as a single dosage form called “Fixed-Dose Combinations” (FDCs) play an essential role in gl...
Source: Current Therapeutic Research - February 1, 2017 Category: Drugs & Pharmacology Source Type: research
In defense of pharmaceutically enhancing human morality
Conclusions I will conclude with the view that in the light of Kantian ethics we might consider moral enhancement by pharmaceutical means even as a perfect duty for moral agents. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 30, 2017 Category: Drugs & Pharmacology Source Type: research
A Case of Severe Iron Deficiency Anemia Associated with Chronic Proton Pump Inhibitor Use
We present the case of a 58-year-old male with severe iron deficiency anemia due to malabsorption suspected to be caused by chronic PPI use. Extensive medical workup failed to reveal any definitive source of bleeding. An iron malabsorption test confirmed that iron was not being absorbed from the gastrointestinal tract. The Naranjo Adverse Drug Reaction Probability Scale and the Horn and Hansten Drug Interaction Probability Scale are suggestive of an association between chronic PPI use and the observed iron deficiency anemia. However, the patient’s death and lack of an autopsy prevented confirmatory follow-up data from be...
Source: Current Therapeutic Research - January 21, 2017 Category: Drugs & Pharmacology Source Type: research
