Population Pharmacokinetics of Amikacin in Suspected Cases of Neonatal Sepsis in A Low-Resource African Setting: A Prospective Non-Randomized Single-Site Study
Conclusions The V and half-life of amikacin in this cohort varied from that reported in non-African populations, and the high trough and low peak amikacin concentrations in both term and preterm neonates suggest strategies to optimize amikacin dosing are required in this population. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 20, 2017 Category: Drugs & Pharmacology Source Type: research
Challenges of Optimal Antibiotic Therapy for Community-Acquired Pneumonia in Children
Conclusions Effective and timely treatment is required for CAP and empirical antibiotics are evidence-based and appropriate in most settings. However, better diagnostics and education to target treatment may help to prevent antibiotic resistance. Ensuring the secure financing of clean food and water, sanitation and public health infrastructure are also required to reduce the burden of disease in children in developing countries. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 16, 2017 Category: Drugs & Pharmacology Source Type: research
Evaluation of the Efficacy and Safety of Vonoprazan in Patients with Nonerosive Gastroesophageal Reflux Disease: A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
Conclusions Vonoprazan at doses of 10 mg and 20 mg are not superior to placebo with respect to proportion of days without heartburn, whereas the mean severity of heartburn is lower with vonoprazan compared with placebo in patients with NERD. ClinicalTrials.gov identifier: NCT01474369. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - January 12, 2017 Category: Drugs & Pharmacology Source Type: research
A Multicenter, Randomized, Open-Label Trial: Efficacy of Once-Daily Versus Twice-Daily Double-Dose Rabeprazole on Refractory Gastroesophageal Reflux Disease-Related Symptoms and Quality of Life
Conclusions In patients with refractory GERD, there was no significant difference in GOS scale score, PSQI, or recurrence rate between the groups. With regard to subscores of the SF-8, the 10 mg BID group might be potentially effective. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 28, 2016 Category: Drugs & Pharmacology Source Type: research
The Cuban Public Health System Focuses Research on Community Needs
Publication date: Available online 28 December 2016 Source:Current Therapeutic Research Author(s): Roberto Cañete Villafranca (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 27, 2016 Category: Drugs & Pharmacology Source Type: research
A 3-Arm Randomized Trial for Achilles Tendinopathy: Eccentric Training, Eccentric Training Plus a Dietary Supplement Containing Mucopolysaccharides, or Passive Stretching Plus a Dietary Supplement Containing Mucopolysaccharides
Conclusions MCVC seems to be therapeutically useful for management of tendinopathies, providing some additional benefit to physical therapy. This is especially evident in early stages of the disease, when the tendon does not present severe matrix and vascular changes. ClinicalTrials.gov identifier NCT01691716. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 23, 2016 Category: Drugs & Pharmacology Source Type: research
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Vonoprazan in Patients with Nonerosive Gastroesophageal Reflux Disease
Conclusions Vonoprazan 10mg and 20mg are not superior to placebo with respect to proportion of days without heartburn whereas the mean severity of heartburn is lower with vonoprazan compared with placebo in patients with NERD. Registration ClinicalTrials.gov: NCT01474369 Funding Takeda Pharmaceutical Company Limited (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 21, 2016 Category: Drugs & Pharmacology Source Type: research
A Multicenter, Randomized, Open-labeled Trial: Efficacy of Once-daily vs. Twice-daily Double-Dose Rabeprazole on Refractory Gastroesophageal Reflux Disease-Related Symptoms and Quality of Life
Conclusion In patients with refractory GERD, there was no significant difference in GOS, PSQI, or recurrence rate between the groups. With regards to sub-scores of SF-8, however, the 10 mg twice-daily RPZ group might be potentially effective. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 25, 2016 Category: Drugs & Pharmacology Source Type: research
A three-arm randomized trial for Achilles tendinopathy: eccentric training, eccentric training plus a dietary supplement containing mucopolysaccharides or passive stretching plus dietary supplement containing mucopolysaccharides
Conclusions MCVC seems to be safe and therapeutically useful for management of tendinopathies, providing some additional benefit to the physical therapy. This is especially evident in early stages of the disease, when the tendon doesn’t present severe matrix and vascular changes. Trial registration NCT01691716, September 2012. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 18, 2016 Category: Drugs & Pharmacology Source Type: research
Preclinical Evaluation of Tolerability of a Selective, Bacteriostatic, Locally Active Vaginal Formulation
Conclusions This favorable preclinical profile is encouraging and supports clinical studies on Polybactum Type 1 ovules for the prevention and management of recurring bacterial vaginosis. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 28, 2016 Category: Drugs & Pharmacology Source Type: research
A Novel Topical Combination Ointment with Antimicrobial Activity against Methicillin-Resistant Staphylococcus aureus, Gram-Negative Superbugs, Yeasts, and Dermatophytic Fungi
Conclusions The results of this study suggest that this combination ointment has a broad in vitro spectrum of antimicrobial activity against both more common bacterial and fungal pathogens and may be particularly useful for treatment of infections by multidrug-resistant organisms. Additional studies are warranted to investigate the full clinical utility as a therapeutic agent and also for possible infection control interventions. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 30, 2016 Category: Drugs & Pharmacology Source Type: research
A Novel Topical Combination Ointment with Antimicrobial Activity against Methicillin-Resistant Streptococcus aureus, Gram-Negative Superbugs, Yeasts, and Dermatophytic Fungi
Conclusions The results of this study suggest that this combination ointment has a broad in vitro spectrum of antimicrobial activity against both more common bacterial and fungal pathogens and may be particularly useful for treatment of infections by multidrug-resistant organisms. Additional studies are warranted to investigate the full clinical utility as a therapeutic agent and also for possible infection control interventions. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 14, 2016 Category: Drugs & Pharmacology Source Type: research
Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults: An Open-Label, Randomized, Single-Dose, Crossover, Relative Bioavailability Study
Conclusions Data from this study of a single dose of 11 g oral NAC demonstrated that effervescent NAC tablets and oral solution NAC met the regulatory criteria for bioequivalence in fasting healthy adult subjects. Effervescent NAC tablets appear to be a more palatable alternative for treatment of acetaminophen overdose. ClinicalTrials.gov identifier: NCT02723669. (Curr Ther Res Clin Exp. 2016; 83C:1–7) © 2016 Elsevier HS Journals, Inc. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 13, 2016 Category: Drugs & Pharmacology Source Type: research
Mebendazole Is a Potential Alternative in the Treatment of Giardia duodenalis Infection
Publication date: 2016 Source:Current Therapeutic Research, Volume 80 Author(s): Roberto Cañete (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 11, 2016 Category: Drugs & Pharmacology Source Type: research
An Open-Label, Randomized, Single-Dose, Crossover Relative Bioavailability Study of Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adult Subjects
Conclusions Data from this study of a single dose of 11 g of oral NAC demonstrated that effervescent NAC tablets and oral solution NAC met the regulatory criteria for bioequivalence in fasting healthy adult subjects. Effervescent NAC tablets appear to be a more palatable alternative for treatment of acetaminophen overdose. ClinicalTrials.gov identifier NCT 02723669 (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 11, 2016 Category: Drugs & Pharmacology Source Type: research
