Open Label Trial of the Efficacy and Safety Profile of Rikkunshito used for the Treatment of Gastrointestinal Symptoms in Patients with Parkinson’s Disease: A Pilot Study
ConclusionsRKT may improve anorexia in patients with PD. The positive effects of RKT on depression and anorexia may improve the overall quality of life of these patients. The benefits of RKT identified in our pilot study will need to be confirmed in a randomized, double-blind, controlled trial. UMIN Clinical Trial Registry identifier: UMIN000009626. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Can a Selective Serotonin Reuptake Inhibitor Act as a Glutamatergic Modulator?
Publication date: 2017Source: Current Therapeutic Research, Volume 87Author(s): Marcos Emilio FrizzoAbstractSertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft. However, the biological effects of these drugs seem to be more complex than their traditionally described mechanism of action. Among their actions is the inhibition of different types of Na+ and K+ channels, as well as of glutamate uptake activity. The clearance of extracellular glutama...
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Effects of Dapagliflozin on Body Composition and Liver Tests in Patients with Nonalcoholic Steatohepatitis Associated with Type 2 Diabetes Mellitus: A Prospective, Open-label, Uncontrolled Study
ConclusionsDapagliflozin was associated with improvements in body composition, most likely a reduction in visceral fat, which occurred together with improvements in liver tests and metabolic variables in patients with NASH-associated with T2DM.UMIN Clinical Trial Registry identifier: UMIN000023574. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Response of Gait Output and Handgrip Strength to Changes in Body Fat Mass in Pre- and Postmenopausal Women
ConclusionsBFM may adversely influence walking balance at postmenopause, whereas HGS may enhance gait output at premenopause but not postmenopause. Therefore, muscle strengthening alone may not enhance gait output in postmenopausal women without balance training. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Hyaluronic Acid Single Intra-Articular Injection in Knee Osteoarthritis: A Multicenter Open Prospective Study (ART-ONE 75) with Placebo Post Hoc Comparison
ConclusionsThe present study suggests the clinical efficacy of a single intra-articular injection of 3 mL intra-articular hyaluronic acid solution containing 75 mg high molecular weight (>2 MDa) native hyaluronic acid. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Comparative Study with a Lip Balm Containing 0.5% Propolis Special Extract GH 2002 versus 5% Aciclovir Cream in Patients with Herpes Labialis in the Papular/Erythematous Stage: A Single-blind, Randomized, Two-arm Study
ConclusionsA formulation of 0.5% propolis GH 2002 extract lip balm was found to be superior in the treatment of episodes of herpes labialis over 5% aciclovir cream in patients in the papular/erythematous phase upon inclusion. EudraCT Registration No. 2006-001971-38. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Investigating Tick-borne Flaviviral-like Particles as a Delivery System for Gene Therapy
ConclusionsThe abundant virologic and cellular findings in this study show the natural processing and safety of inserting flaviviral structural genes into suicidal VLP shuttles. Thus, we propose that these VLPs are a suitable gene delivering system model in gene therapy. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Experimental Hemorrhagic Shock Protocol in Swine Models: The Effects of 21-Aminosteroid on the Small Intestine
ConclusionsDespite few initial findings of this study suggesting that administration of lazaroid U-74389G may have some potential in attenuation of the effects of hemorrhagic shock in the small intestine of swine models, no differences remained after correction for multiple comparisons was made. Therefore, further research is required to investigate this result thoroughly. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Efficacy and Safety Profile of Z-215 (Azeloprazole Sodium), a Proton Pump Inhibitor, Compared with Rabeprazole Sodium in Patients with Reflux Esophagitis: A Phase II, Multicenter, Randomized, Double-Blind, Comparative Study
ConclusionsZ-215 was as effective and well tolerated as 10 mg RPZ in the treatment of RE in this selected population. CYP2C19 genotype status may not influence the efficacy and safety of Z-215. There were no clear dose–response effects between Z-215 doses in the endoscopic healing of RE. These findings suggest that Z-215 may be 1 option for the initial treatment of RE. ClinicalTrials.gov identifier: NCT 02463643. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Tolerability and Safety Profile of a New Brand-Generic Product of Glatiramer Acetate in Iranian Patients with Relapsing-Remitting Multiple Sclerosis: An Observational Cohort Study
ConclusionsThe 40 mg brand-generic glatiramer acetate product was well tolerated in this selected group of Iranian patients with relapsing-remitting multiple sclerosis, and patient adherence was favorable over 1 year. (Curr Ther Res Clin Exp. 2018; 79:XXX–XXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Retraction notice to "A Randomized, Double-Blind Comparison of Granisetron Alone and Combined with Dexamethasone for Post–Laparoscopic Cholecystectomy Emetic Symptoms": [CTR 64/8 (2003) 514- 521]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).The following articles are being retracted as a result of overwhelming evidence of fabrication, related to the fact that the distributions of many variables reported by Dr Fujii in these studies could not have occurred by chance, and the inability of Dr Fujii’s institutions to attest to the integrity of the study and/or its data conducted under their auspices. Because both the Journal’s independent and collaborative attempts have not yielded this required information, the Journal has dec...
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Retraction notice to "Treatment of postoperative emetic symptoms with granisetron in women undergoing abdominal hysterectomy: A randomized, double-blind, placebo-controlled, dose-ranging study": [CTR 65/4 (2004) 321-329]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal).This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).The following articles are being retracted as a result of overwhelming evidence of fabrication, related to the fact that the distributions of many variables reported by Dr Fujii in these studies could not have occurred by chance, and the inability of Dr Fujii’s institutions to attest to the integrity of the study and/or its data conducte...
Source: Current Therapeutic Research - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Clinical Efficacy and Safety of Combination Therapy with Amlodipine and Olmesartan or an Olmesartan/Hydrochlorothiazide Compound for Hypertension: A Prospective, Open-Label, and Multicenter Clinical Trial in China
ConclusionsThe combination therapy with OLM or OLM/HCTZ was well tolerated. The total incidence of adverse events was 42.9% (n = 176). Most of the adverse events were mild in severity (39.5%; n = 162) and not associated with the drugs (33.2%). In conclusion, combination therapy with AML, OLM, or OLM/HCTZ can significantly lower BP safely and achieve a high BP control rate in patients with mild-to-moderate hypertension in China. ClinicalTrial.org identifier: ChiCTR-ONC-12001963. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 5, 2018 Category: Drugs & Pharmacology Source Type: research
Open Label Trial of the Efficacy and Safety Profile of Rikkunshito used for the Treatment of Gastrointestinal Symptoms in Patients with Parkinson’s Disease: A Pilot Study
ConclusionsRKT may improve anorexia in patients with PD. The positive effects of RKT on depression and anorexia may improve the overall quality of life of these patients. The benefits of RKT identified in our pilot study will need to be confirmed in a randomized, double-blind, controlled trial. UMIN Clinical Trial Registry identifier: UMIN000009626. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 5, 2018 Category: Drugs & Pharmacology Source Type: research
Can a Selective Serotonin Reuptake Inhibitor Act as a Glutamatergic Modulator?
Publication date: 2017Source: Current Therapeutic Research, Volume 87Author(s): Marcos Emilio FrizzoAbstractSertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft. However, the biological effects of these drugs seem to be more complex than their traditionally described mechanism of action. Among their actions is the inhibition of different types of Na+ and K+ channels, as well as of glutamate uptake activity. The clearance of extracellular glutama...
Source: Current Therapeutic Research - July 5, 2018 Category: Drugs & Pharmacology Source Type: research
