Mebendazole in the Treatment of Giardia Duodenalis, from Clinical Trial to Daily Practice
Publication date: Available online 31 May 2016 Source:Current Therapeutic Research Author(s): Roberto Cañete (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 31, 2016 Category: Drugs & Pharmacology Source Type: research
Bioequivalence of Alendronate and Vitamin D3 in a Combination Tablet Versus Corresponding-Dose Individual Tablets in Healthy Taiwanese Volunteers, Determined Using a Novel Plasma Alendronate Assay
Conclusions The combination tablet was considered bioequivalent to coadministration based on ALN AUC0–∞ and unadjusted vitamin D3 parameters. Slight differences for ALN AUC0–last and Cmax (upper 90% CIs outside the bounds) were not considered clinically significant. The combination tablet was well tolerated. No serious adverse experiences were reported. © 2015. The Authors. Published by Elsevier Inc. All rights reserved. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 11, 2015 Category: Drugs & Pharmacology Source Type: research
Investigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats
Conclusions The results indicate Glu-3 OXM-like analogues might not be suitable tools to investigate the mechanism of OXM analogue action in a rat model because they significantly increase body weight independent of food intake. Glu-3 OXM analogues are partial agonists at the rat GCGr and may also act as antagonists, possibly resulting in the observed increase in body weight. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 10, 2015 Category: Drugs & Pharmacology Source Type: research
Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis via the Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway in Rats with Epilepsy
Conclusions These results indicate that myocardial cell apoptosis may contribute to myocardial injury in epilepsy. EPO protects myocardial cells from apoptosis via the JAK2/STAT5 pathway in rats with experimental epilepsy, whereas CEPO exerts antiapoptotic activity perhaps via a pathway independent of JAK2/STAT5 signaling. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 10, 2015 Category: Drugs & Pharmacology Source Type: research
Bioequivalence of Alendronate and Vitamin D3 in a Combination Tablet in Healthy Taiwanese Volunteers, using a Novel Plasma Alendronate Assay
This study was designed to demonstrate that alendronate (ALN)/vitamin D3 combination tablets (ALN/D5600) are bioequivalent to corresponding doses of ALN and vitamin D3 as individual tablets in healthy Taiwanese subjects. Methods In this open-label, randomized, two-period, crossover study, 68 volunteers were randomized to a single ALN/D5600 combination tablet or corresponding doses of ALN 70 mg + vitamin D3 5600 IU (2× 2800 IU), followed by a 12-day washout period and administration of the alternate formulation. Plasma ALN levels were measured using a newly developed assay. Geometric mean ratios (GMRs) of ALN area under ...
Source: Current Therapeutic Research - November 17, 2015 Category: Drugs & Pharmacology Source Type: research
Chemical Stability of Telavancin in Elastomeric Pumps
Publication date: Available online 22 October 2015 Source:Current Therapeutic Research Author(s): Patrick Sand, Traci Aladeen, Paul Kirkegaard, Dennis LaChance, Christine Slover Purpose To evaluate the chemical stability of telavancin ([VIBATIV®] – Theravance Biopharma US, Inc.), a lipoglycopeptide antibiotic with activity against methicillin-resistant Staphylococcus aureus, in 2 types of elastomeric pumps, the Intermate® Infusion System (Baxter International Inc.) and the Homepump Eclipse® (I-Flow Corporation). Methods Different sizes of the Baxter (105 mL and 275 mL) and I-Flow (100 mL and 250 mL) pu...
Source: Current Therapeutic Research - November 17, 2015 Category: Drugs & Pharmacology Source Type: research
Investigating The Glucagon Receptor and GLP-1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats
Conclusion The results indicate Glu-3 OXM analogues might not be suitable tools to investigate the mechanism of oxyntomodulin analogue action in a rat model as they significantly increase bodyweight independently of food intake. Glu-3 OXM analogues are partial agonists at the rat GCGr and may also act as antagonists, possibly resulting in the observed increase in bodyweight. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 17, 2015 Category: Drugs & Pharmacology Source Type: research
Post-reconstitution Stability of Telavancin with Commonly Used Diluents and Intravenous Infusion Solutions
Publication date: Available online 5 November 2015 Source:Current Therapeutic Research Author(s): Zhengtian Gu, Carlos Parra, Anissa Wong, Alice Nguyen, Ronnie Cheung, Thomas Catalano Purpose The post-reconstitution chemical stability and microbial challenge hold-time of nonpreserved telavancin for injection was determined using common reconstitution diluents and intravenous (IV) infusion solutions stored at room temperature with light (ambient) or at 2°C–8°C without light (refrigeration). Methods Telavancin was reconstituted with 5% dextrose (D5W), 0.9% normal saline (NS), or sterile water (15 mg/mL)...
Source: Current Therapeutic Research - November 17, 2015 Category: Drugs & Pharmacology Source Type: research
Clinical Efficacy and Safety of Combination Therapy with Amlodipine and Olmesartan or Olmesartan /Hydrochlorothiazide Compound for Hypertension: A Prospective, Open-Label, and Multicenter Clinical Trial in China
Conclusions The combination therapy with OLM or OLM/HCTZ was well tolerated. The total incidence of adverse events (AEs) was 42.9% (n=176). Most of the AEs were mild (39.5%, n=162) in severity and not associated with the drugs (33.2%). In conclusion, the combination therapy with AML, OLM or OLM/HCTZ compound can significantly lowering BP safely and achieve high BP control rate in mild-to-moderate hypertension patients in China. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 9, 2015 Category: Drugs & Pharmacology Source Type: research
Early Clinical Detection of Pharmacologic Response in Insulin Action in a Nondiabetic Insulin-Resistant Population
Conclusions Significant changes in insulin action across multiple insulin-sensitive tissues can be detected within 2 weeks of initiation of insulin-sensitizing therapy with pioglitazone in obese patients with nondiabetic insulin resistance. ClinicalTrials.gov identifier: NCT01115712. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 26, 2015 Category: Drugs & Pharmacology Source Type: research
Pill Properties that Cause Dysphagia and Treatment Failure
Conclusions Our survey results suggest that 4 out of 5 adult Americans take several pills daily, and do so without undue effort. It also suggests that half of today’s Americans encounter pills that are hard to swallow. Up to 4% of our participants gave up on treatments because they could not swallow the prescribed pills. Up to 7% categorically rejected taking pills that are hard to swallow. Specific material properties are widely blamed for making pills hard to swallow; extra-large capsules and tablets are universally feared, whereas medium-sized pills with a smooth coating are widely preferred. Our findings suggest that...
Source: Current Therapeutic Research - September 26, 2015 Category: Drugs & Pharmacology Source Type: research
Use of Arctium lappa Extract Against Acetaminophen-Induced Hepatotoxicity in Rats
Conclusions Arctium lappa can prevent most of the hepatic tissue damage caused by acetaminophen overdose in rats. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 26, 2015 Category: Drugs & Pharmacology Source Type: research
Pill Properties Causing Dysphagia and Treatment Failure
Conclusions Our survey suggests that four out of five adult Americans take several pills daily, and do so without undue effort. It also suggests, that half of today’s Americans encounter(ed) pills that were hard to swallow. Up to 4% of our participant’s gave up on treatments because they could not swallow the prescribed pills. Up to 7% categorically reject taking pills that are hard to swallow pill. Specific material properties are widely blamed for making pills hard to swallow: extra-large capsules and tablets are universally feared; medium sized pills with a smooth coating are widely preferred. Our findings suggest t...
Source: Current Therapeutic Research - August 21, 2015 Category: Drugs & Pharmacology Source Type: research
Early Clinical Detection of Pharmacologic Response in Insulin Action in a Non-diabetic Insulin Resistant Population
Conclusions Significant changes in insulin action across multiple insulin sensitive tissues can be detected within 2 weeks of initiation of insulin-sensitizing therapy with pioglitazone in obese non-diabetic insulin resistant subjects. Clinical Trial Registration Number NCT01115712. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 14, 2015 Category: Drugs & Pharmacology Source Type: research
Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis Via the JAK2/STAT5 Pathway in Rats with Epilepsy
Conclusions These results indicate that myocardial cell apoptosis may contribute to myocardial injury in epilepsy. EPO protects myocardial cells from apoptosis via the JAK2/STAT5 pathway in rats with experimental epilepsy, whereas CEPO exerts anti-apoptotic activity perhaps via a pathway independent of JAK2/STAT5 signaling. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 5, 2015 Category: Drugs & Pharmacology Source Type: research
