Investigating The Glucagon Receptor and GLP-1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats

Conclusion The results indicate Glu-3 OXM analogues might not be suitable tools to investigate the mechanism of oxyntomodulin analogue action in a rat model as they significantly increase bodyweight independently of food intake. Glu-3 OXM analogues are partial agonists at the rat GCGr and may also act as antagonists, possibly resulting in the observed increase in bodyweight.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research