Comparative Study with a Lip Balm Containing 0.5% Propolis Special Extract GH 2002 versus 5% Aciclovir Cream in Patients with Herpes Labialis in the Papular/Erythematous Stage: A Single-blind, Randomized, Two-arm Study
Conclusions A formulation of 0.5% propolis GH 2002 extract lip balm was found to be superior in the treatment of episodes of herpes labialis over 5% aciclovir cream in patients in the papular/erythematous phase upon inclusion. EudraCT Registration No. 2006-001971-38. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - December 19, 2017 Category: Drugs & Pharmacology Source Type: research
First International Conference on Health Research, Hannover, Germany
Publication date: Available online 14 October 2017 Source:Current Therapeutic Research Author(s): Gerhard Fortwengel (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 19, 2017 Category: Drugs & Pharmacology Source Type: research
Investigating Tick-borne Flaviviral-like Particles as a Delivery System for Gene Therapy
Conclusion The abundant virological and cellular findings in this study showed natural processing and safety of the flaviviral structural genes into suicidal VLP shuttles, thus proposed these VLPs as a suitable gene delivering system model in gene therapy. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - November 19, 2017 Category: Drugs & Pharmacology Source Type: research
Which Benefits are Mentioned Most Often in Drug Development Publications?
Conclusions Both theoretically expected and actually reported benefits in the majority of the included publications emphasized the importance of individual patient benefits from drug development rather than the collective benefits to society in general. The authors of these publications emphasized the right of each individual patient/subject to look for and expect some personal benefit from participating in a clinical trial; rather than considering societal benefit as a top priority [2]. From an ethical point of view, however, the benefits each individual patient received from their participation in a clinical trial might ...
Source: Current Therapeutic Research - November 19, 2017 Category: Drugs & Pharmacology Source Type: research
Comparative Study with a Lip Balm Containing Propolis Special Extract GH 2002 0,5 % vs. Aciclovir Cream 5 % in Patients with Herpes labialis in the Papular / Erythematous stage. A Single-blind, Randomized Two-arm Study
Conclusions Propolis GH 2002 extract lip balm 0.5 % was found superior in the treatment of episodes of Herpes labialis over aciclovir cream 5 % in patients in the papular/erythematous phase upon inclusion. EudraCT Registration No. 2006-001971-38 (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 14, 2017 Category: Drugs & Pharmacology Source Type: research
Editorial: First International Conference on Health Research, Hannover, Germany
Publication date: Available online 14 October 2017 Source:Current Therapeutic Research Author(s): Gerhard Fortwengel (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 14, 2017 Category: Drugs & Pharmacology Source Type: research
Clinical Evaluation of Terap C Vaccine in Combined Treatment with Interferon and Ribavirin in Patients with Hepatitis C
Conclusions Vaccination with Terap C in patients with chronic HCV infection was safe and well tolerated. Clinical trial protocol code: IG/VHI/HC/0701; Public Register Code: RPCEC00000074. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - October 7, 2017 Category: Drugs & Pharmacology Source Type: research
Effects of Dapagliflozin on Body Composition and Liver Tests in Patients with Nonalcoholic Steatohepatitis Associated with Type 2 Diabetes Mellitus: A Prospective, Open-label, Uncontrolled Study
Conclusions Dapagliflozin was associated with improvements in body composition, most likely a reduction in visceral fat, which occurred together with improvements in liver tests and metabolic variables in patients with NASH-associated with T2DM. UMIN Clinical Trial Registry identifier: UMIN000023574. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - September 5, 2017 Category: Drugs & Pharmacology Source Type: research
Open label trial of the efficacy and safety profile of rikkunshito used for the treatment of gastrointestinal symptoms in patients with Parkinson ’s disease: A pilot study
Conclusions RKT may improve anorexia in patients with PD. The positive effects of RKT on depression and anorexia may improve the overall QOL of these patients. The benefits of RKT identified in our pilot study will need to be confirmed in a randomized, double-blind, controlled trial. UMIN Clinical Trial Registry identifier: UMIN000009626. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - August 1, 2017 Category: Drugs & Pharmacology Source Type: research
Effects of dapagliflozin on body composition and liver tests in patients with non-alcoholic steatohepatitis associated with type 2 diabetes mellitus: A prospective, open-label, uncontrolled study
Conclusions Dapagliflozin was associated with improvements in body composition, most likely a reduction in visceral fat, which occurred together with improvements in liver tests and metabolic variables in patients with NASH associated with T2DM. Clinical trial registration: UMIN000023574 (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 8, 2017 Category: Drugs & Pharmacology Source Type: research
Can a selective serotonin reuptake inhibitor act as a glutamatergic modulator?
Publication date: Available online 8 July 2017 Source:Current Therapeutic Research Author(s): Marcos Emilio Frizzo Sertraline (Zoloft) and fluoxetine (Prozac) are selective serotonin reuptake inhibitors whose antidepressant mechanism of action is classically attributed to an elevation of the extracellular levels of serotonin in the synaptic cleft. However, the biological effects of these drugs seem to be more complex than their traditionally described mechanism of action. Among their actions is the inhibition of different types of Na+ and K+ channels, as well as of glutamate uptake activity. The clearance of extracellul...
Source: Current Therapeutic Research - July 8, 2017 Category: Drugs & Pharmacology Source Type: research
Extended-Release Guaifenesin/Pseudoephedrine Hydrochloride for Symptom Relief in Support of a Wait-and-See Approach for the Treatment of Acute Upper Respiratory Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Study
Conclusions The study found that a wait and see approach was associated with decreased antibiotic use. In addition, the use of a guaifenesin pseudoephedrine combination product provided an effective symptom control compared to a placebo and a well-tolerated first-line strategy for the management of URTIs. This study was not designed to assess the effects of guaifenesin or pseudoephedrine individually. Other limitations include the need for better clinical methods to assess the effectiveness of treatments for acute symptoms of patients with URTIs. ClinicalTrials.gov identifier: NCT01202279. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 10, 2017 Category: Drugs & Pharmacology Source Type: research
Current Condition of Chronic Hepatitis B Virus Infection in Cuban Adults
Conclusions Patients with chronic HBV infection are still a health problem in the adult Cuban population, especially in patients with concomitant malignancies. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 6, 2017 Category: Drugs & Pharmacology Source Type: research
Roads to Health in Developing Countries: Understanding the Intersection of Culture and Healing
Conclusion In general, we, as human beings, are guided in our health care decisions by past experiences, family and friends, social networks, cultural beliefs, customs, tradition, professional knowledge, and intuition. No medical system has been shown to address all of these elements; hence, the need for collaboration, acceptance, and partnership between all systems of care in cultural communities. In developing countries, the roads to health are incomplete without an examination of the intersection of culture and healing. Perhaps mutual exclusiveness rather inclusiveness of these 2 dominant health systems is the greatest ...
Source: Current Therapeutic Research - May 16, 2017 Category: Drugs & Pharmacology Source Type: research
Curative Metatarsal Bone Surgery Combined with Intralesional Administration of Recombinant Human Epidermal Growth Factor in Diabetic Neuropathic Ulceration of the Forefoot: A Prospective, Open, Uncontrolled, Nonrandomized, Observational Study
Conclusions The combination of curative metatarsal bone surgery with intralesional administration of recombinant human EGF resulted in a significant reduction in the re-epithelization time, recidivism, and development of new diabetic lesions. The safety profile was appropriate. However, more randomized, triple-blind, and placebo trials are needed to evaluate the efficacy and safety of this new therapy. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 16, 2017 Category: Drugs & Pharmacology Source Type: research
