Bioequivalence Study of 100-mg Cilostazol Tablets in Healthy Thai Adult Volunteers
ConclusionsBestazol 100-mg tablet was bioequivalent to Pletaal 100-mg tablet. Thus, the formulations can be used interchangeably in clinical practice. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - July 23, 2019 Category: Drugs & Pharmacology Source Type: research
Bioequivalence Study of 100 mg Cilostazol Tablets in Healthy Thai Adult Volunteers
This study was conducted at the Siriraj Clinical Research Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Each volunteer was initially treated according to either the Test-Reference (TR) or the Reference-Test (RT) sequence, after which each subject was switched to the other study sequence after a two-week washout period. Pharmacokinetic analysis was performed using log-transformed ratios (test/reference) for Cmax, AUC0-tlast, AUC0-∞, Tmax, t1/2, and λZ for both cilostazol and 3,4-dehydro-cilostazol (its active metabolite) with 90% confidence interval. Physical examination, clinical l...
Source: Current Therapeutic Research - July 16, 2019 Category: Drugs & Pharmacology Source Type: research
Comparison Of Ondansetron, Tropisetron And Palonosetron For The Prevention Of Postoperative Nausea And Vomiting After Middle Ear Surgery
Conclusion: The results of the current study support those of earlier studies that suggest that palonosetron was statistically more effective than the other two formulations in the prevention of PONV in patients who have undergone middle ear surgery. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research
Erythrocyte partitioning profile of Isosteviol in human and rat blood
ConclusionsThe findings suggest that isosteviol preferentially partitions into plasma compartments in man and rat. The significance of this profile for the efficacy, tissue uptake and retention of isosteviol will, however, have to be further studied. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research
Schistosomiasis: Life Cycle, Diagnosis, and Control
Publication date: Available online 22 June 2019Source: Current Therapeutic ResearchAuthor(s): Martin L. NelwanAbstractHuman schistosomiasis is a parasitic disease caused by blood-worms that infect multiple organs, including the liver, intestine, bladder, and urethra. The life cycle of these parasites involves two hosts: snails and mammals. Manifestations of schistosomiasis can be acute or chronic. Clinical manifestations of acute schistosomiasis can include fever and headache. Symptoms of chronic infections can include dysuria and hyperplasia. Infections can occur in several sites, including the bile ducts, intestine, and ...
Source: Current Therapeutic Research - June 22, 2019 Category: Drugs & Pharmacology Source Type: research
Inyección Intraarticular Única de Ácido Hialurónico en la Artrosis de Rodilla: Estudio Multicéntrico Prospectivo Abierto (ART-ONE 75) mediante Comparación Post-Hoc con Placebo
Publication date: 2019Source: Current Therapeutic Research, Volume 90Author(s): Dominique BARON, Christian FLIN, Jérôme PORTERIE, Jacques DESPAUX, Patrice VINCENTResumenIntroducciónLa viscosuplementación del líquido sinovial mediante la inyección intraarticular (IA) de ácido hialurónico (AH) es un tratamiento sintomático ampliamente utilizado en la artrosis de rodilla (AR). Además de los productos diseñados para realizar inyecciones múltiples (normalmente de 3 a 5 inyecciones, en intervalos de 1 semana), se presta especial atención a los productos de una única inyección, ya que ofrecen ventajas específicas,...
Source: Current Therapeutic Research - May 23, 2019 Category: Drugs & Pharmacology Source Type: research
Effects of Periodic Intensive Insulin Therapy: An Updated Review
ConclusionsRecent advancements show that IIT is an effective option for both type 1 diabetes mellitus and type 2 diabetes mellitus patient populations. This treatment resembles normal pancreatic function so closely that it has significantly reduced the effects of relatively common complications of diabetes in comparison to standard treatments. Thus, this new treatment is a promising advancement in the management of diabetes. (Curr Ther Res Clin Exp. 2019; 80:XXX–XXX). (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 17, 2019 Category: Drugs & Pharmacology Source Type: research
Predictors of Health-Related Quality of Life Among Patients with Type II Diabetes Mellitus Who Are Insulin Users: A Multidimensional Model
ConclusionsThis study suggests the valuable effect of insulin therapy among patients with T2DM compared with OAMs on health-related quality of life, medication adherence, and health state. Insulin users reported they had better diabetes-related knowledge and treatment adherence characteristics than noninsulin users. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 10, 2019 Category: Drugs & Pharmacology Source Type: research
Inyección intraarticular única de ácido hialurónico en la artrosis de rodilla: estudio multicéntrico prospectivo abierto (ART-ONE 75) mediante Comparación Post-Hoc con Placebo
Publication date: Available online 2 May 2019Source: Current Therapeutic ResearchAuthor(s): Dominique BARON, Christian FLIN, Jérôme PORTERIE, Jacques DESPAUX, Patrice VINCENTResumenIntroducciónLa viscosuplementación del líquido sinovial mediante la inyección intraarticular (IA) de ácido hialurónico (AH) es un tratamiento sintomático ampliamente utilizado en la artrosis de rodilla (AR). Además de los productos diseñados para realizar inyecciones múltiples (normalmente de 3 a 5 inyecciones, en intervalos de 1 semana), se presta especial atención a los productos de una única inyección, ya que ofrecen ventajas e...
Source: Current Therapeutic Research - May 3, 2019 Category: Drugs & Pharmacology Source Type: research
An Updated Review on the Effects of Periodic Intensive Insulin Therapy
ConclusionsRecent advancements have proven that Intensive Insulin Therapy is an effective option for both T1DM and T2DM patient populations. This treatment resembles normal pancreatic function so closely that it has significantly reduced the effects of relatively common diabetic complications in comparison to standard treatments. Thus, this new treatment is a promising advancement in the management of diabetes. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 30, 2019 Category: Drugs & Pharmacology Source Type: research
Predictors of Health-related Quality of Life (HRQoL) among Insulin Users of Type II Diabetes Mellitus Patients; a Multidimensional Model
ConclusionThis study suggested the valuable effect of insulin therapy among patients with T2DM compared to oral antidiabetic medications on health-related quality of life, medication adherence, and health state. Insulin users reported they had better diabetes-related knowledge and treatment adherence characteristics than non-insulin users. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 26, 2019 Category: Drugs & Pharmacology Source Type: research
Intra-Articular Hyaluronic Acid in the Symptomatic Treatment of Knee Osteoarthritis: A Meta-Analysis of Single-Injection Products
ConclusionsThere are certainly limits to the post hoc placebo comparison method, for individual studies. But for each synthesis per subgroup or group, the results were properly confirmed using multiple statistical approaches and weighing methods. This meta-analysis suggests that monoinjections produce results similar to multi-injections of IA HA in terms of pain relief in the treatment of knee osteoarthritis. (Curr Ther Res Clin Exp. 2019; 80:XXX–XXX) (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 2, 2019 Category: Drugs & Pharmacology Source Type: research
Concurrent Quinidine and Phenobarbital in the Treatment of a Patient with 2 KCNT1 Mutations
We report the case of an infant with 2 KCNT1 mutations who experienced minor relief with quinidine and discuss the drug's important interaction with phenobarbital. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 12, 2019 Category: Drugs & Pharmacology Source Type: research
Intra-articular (IA) hyaluronic acid (HA) in the symptomatic treatment of knee osteoarthritis (OA): a meta-analysis of single injection products (IA HA mono-injections)
DiscussionThere are certainly limits to the post-hoc placebo comparison method, for individual studies. But for each synthesis per subgroup or group, the results were properly confirmed using multiple statistical approaches and weighing methods. This meta-analysis suggests that mono-injections produce results similar to multi-injections of intra articular hyaluronic acid in terms of pain relief in the treatment of knee OA. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 7, 2019 Category: Drugs & Pharmacology Source Type: research
Concurrent quinidine & phenobarbital in the treatment of a patient with two KCNT1 mutations
We report the case of an infant with two KCNT1 mutations who experienced minor relief with quinidine and discuss the drug's important interaction with phenobarbital. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - March 1, 2019 Category: Drugs & Pharmacology Source Type: research
