Is Prostate Biopsy Recommended in Turkish Men with a Prostate-Specific Antigen Level between 2.5 and 4 ng/mL?
Conclusions The cancer detection rate is lower in Turkish men with PSA level in the range of 2.5 to 4.0 ng/mL when compared with men with PSA level in the range of 4.0 to 10.0 ng/mL. Furthermore, most patients in whom cancer was detected who have a PSA level in the range of 2.5 to 4.0 ng/mL are low risk. Therefore, the benefit of TRUSBP in Turkish men with PSA level between 2.5 and 4 ng/mL is low. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 16, 2017 Category: Drugs & Pharmacology Source Type: research
Response of Gait Output and Handgrip Strength to Changes in Body Fat Mass in Pre- and Postmenopausal Women
Conclusions BFM may adversely influence walking balance at postmenopause, whereas HGS may enhance gait output at premenopause but not postmenopause. Therefore, muscle strengthening alone may not enhance gait output in postmenopausal women without balance training. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 15, 2017 Category: Drugs & Pharmacology Source Type: research
Bleeding Risk Related to Upper Gastrointestinal Endoscopic Biopsy in Patients Receiving Antithrombotic Therapy: A Multicenter Prospective Observational Study
Conclusions We found no significant increase in upper-GI bleeding risk following an EGD biopsy in patients taking antithrombotic agents, suggesting its safety without the need for antithrombotic treatment interruption. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 15, 2017 Category: Drugs & Pharmacology Source Type: research
A Bayesian Approach for Population Pharmacokinetic Modeling of Alcohol in Japanese Individuals
Conclusions A population pharmacokinetic model for alcohol was updated. A Bayesian approach allowed interpretation of significant covariate relationships, even if the current dataset is not informative about all parameters. This is the first study reporting an estimate of the effect of the ALDH2 genotype in a PPK model. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 15, 2017 Category: Drugs & Pharmacology Source Type: research
A Case of Severe Iron Deficiency Anemia Associated with Long-Term Proton Pump Inhibitor Use
We present the case of a 58-year-old man with severe iron deficiency anemia due to malabsorption suspected to be caused by long-term PPI use. An extensive medical work up failed to reveal any definitive source of bleeding. An iron malabsorption test confirmed that iron was not being absorbed from the gastrointestinal tract. The Naranjo Adverse Drug Reaction Probability Scale and the Horn and Hansten Drug Interaction Probability Scale are suggestive of an association between long-term PPI use and the observed iron deficiency anemia. However, the patient’s death and lack of an autopsy prevented confirmatory follow-up data ...
Source: Current Therapeutic Research - May 13, 2017 Category: Drugs & Pharmacology Source Type: research
Safety, Efficacy, and Bioavailability of Fixed-Dose Combinations in Type 2 Diabetes Mellitus: A Systematic Updated Review
Publication date: Available online 2 February 2017 Source:Current Therapeutic Research Author(s): Thangavel Mahalingam Vijayakumar, Jayasutha Jayram, Vishnu Meghana Cheekireddy, Dasari Himaja, Yalamanchili Dharma Teja, Damodharan Narayanasamy Purpose Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance. As time progresses, monotherapy often does not provide effective glycemic control, generating the need for an add-on therapy. Hence, multiple oral hypoglycemic agents formulated as a single-dose form called fixed-dose combinations (FDCs) play an essential role in glycemic c...
Source: Current Therapeutic Research - May 13, 2017 Category: Drugs & Pharmacology Source Type: research
Efficacy and Safety of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin on Atherosclerosis, β-Cell Function, and Glycemic Control in Japanese Patients with Type 2 Diabetes Mellitus Who are Treatment Naïve or Poorly Responsive to Antidiabetes Agents: A Multicenter, Prospective Observational, Uncontrolled Study
Conclusions Sitagliptin may have beneficial effects on vascular inflammation and β-cell function in Japanese patients with type 2 diabetes. Pentraxin-3 may be an early predictive marker for detecting the antiatherosclerotic effects of dipeptidyl peptidase-4. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 13, 2017 Category: Drugs & Pharmacology Source Type: research
Esophageal Motility and Rikkunshito Treatment for Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease: A Prospective, Uncontrolled, Open-Label Pilot Study Trial
Conclusions In the pilot study, patients with PPI-refractory NERD had disorders of esophageal and lower esophageal sphincter motility that were improved by RKT. Further studies examining esophageal motor activity of RKT in PPI-refractory NERD are required. University hospital Medical Information Network (UMIN) Clinical Trial Registry identifier: UMIN000003092. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 13, 2017 Category: Drugs & Pharmacology Source Type: research
The Influence of Emerging Markets on the Pharmaceutical Industry
Publication date: Available online 18 April 2017 Source:Current Therapeutic Research Author(s): Maya Tannoury, Zouhair Attieh Emerging markets represent an exceptional opportunity for the pharmaceutical industry. Although a precise definition is not yet available, economists define emerging markets as developing prosperous countries in which investment is expected to result in higher income despite high risks. Qualifying a market as emerging is not merely based on the economic status of the country, but also on several criteria that render the definition applicable to each country. Jim O’Neil, retired chairman of ass...
Source: Current Therapeutic Research - May 13, 2017 Category: Drugs & Pharmacology Source Type: research
Current Conditions of Chronic Hepatitis B Virus Infections in Cuban Adults
Conclusions Patients suffering from chronic hepatitis B are still a health problem in the adult Cuban population, especially in patients with concomitant malignancies. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - May 4, 2017 Category: Drugs & Pharmacology Source Type: research
Extended-release guaifenesin/pseudoephedrine hydrochloride for symptom relief in support of a ‘wait and see’ approach for the treatment of acute upper respiratory tract infections: A randomized, double-blind, placebo-controlled study
This study was not designed to assess the effects of guaifenesin or pseudoephedrine individually. Other limitations include the need for better clinical methods to assess the effectiveness of treatments for acute symptoms of patients with URTIs. Trial registration: ClinicalTrials.gov NCT01202279. Registered 13 September 2010. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 28, 2017 Category: Drugs & Pharmacology Source Type: research
Clinical Evaluation of Terap C Vaccine Candidate in Combined Treatment with Interferon and Ribavirin in Patients with Hepatitis C
Conclusions: Vaccination with Terap C in patients with chronic HCV infection was safe and well tolerated. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 27, 2017 Category: Drugs & Pharmacology Source Type: research
Is Prostate Biopsy Recommended In Men With a PSA Between 2,5 - 4 ng/mL?
Conclusion The cancer detection rate is lower in Turkish men with PSA in the range of 2.5-4.0 ng/mL, when compared to men with PSA in the range of 4.0-10.0 ng/mL. Furthermore, most of cancer detected patients with PSA in the range of 2.5-4.0 ng/mL are low risk. Therefore, we think that benefit of TRUSBP in Turkish men with PSA level between 2.5-4 ng/ml is low. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 18, 2017 Category: Drugs & Pharmacology Source Type: research
Response of Gait Output and Handgrip Strength to Changes in Body Fat Mass in Pre- and Post-Menopausal Women
Conclusion(s) BFM may adversely influence walking balance at post-menopause, while HGS may enhance gait output at pre-menopause but not post-menopause. Therefore, muscle strengthening alone may not enhance gait output in postmenopausal women without balance training. (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
Intralesional administration of human recombinant epidermal growth factor improves healing and reduces amputations in patients with severe diabetic foot ulcers
Publication date: Available online 31 March 2017 Source:Current Therapeutic Research Author(s): Aristides L. Garcia Herrera (Source: Current Therapeutic Research)
Source: Current Therapeutic Research - April 11, 2017 Category: Drugs & Pharmacology Source Type: research
