A Case of Severe Iron Deficiency Anemia Associated with Chronic Proton Pump Inhibitor Use

We present the case of a 58-year-old male with severe iron deficiency anemia due to malabsorption suspected to be caused by chronic PPI use. Extensive medical workup failed to reveal any definitive source of bleeding. An iron malabsorption test confirmed that iron was not being absorbed from the gastrointestinal tract. The Naranjo Adverse Drug Reaction Probability Scale and the Horn and Hansten Drug Interaction Probability Scale are suggestive of an association between chronic PPI use and the observed iron deficiency anemia. However, the patient’s death and lack of an autopsy prevented confirmatory follow-up data from being obtained to connect chronic PPI use as the culprit. While there are currently no recommendations regarding screening for iron deficiency and/or anemia in patients on chronic PPI therapy, physicians should be aware of this potential side effect and consider monitoring in high-risk patients.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research