A Bayesian Approach for Population Pharmacokinetic Modeling of Alcohol in Japanese Subjects

Conclusions A population pharmacokinetic model for alcohol was updated. A Bayesian approach allowed interpretation of significant covariate relationships, even if the current dataset is not informative about all parameters. This is the first study reporting an estimate of the effect of the ALDH2 genotype in a PPK model.
Source: Current Therapeutic Research - Category: Drugs & Pharmacology Source Type: research