Use of Synbiotics for Ulcerative Colitis Treatment.
CONCLUSION: The mechanism of actions in synbiotics supplementation is still unclear and needs more investigation although there are a wide number of data indicating that the synergism between probiotics and prebiotics is able to modulate the inflammatory response through cytokine expression and immune cell modulation induced by probiotic bacteria, that are also able to favour the production of SCFA by prebiotics digestion. SCFA are involved in mucosal barrier stabilization, regulatory T cell induction, promotion of anti-inflammatory cytokines secretion and inhibition of inflammatory factors such as TNF-α. Other: An urgent...
Source: Current Clinical Pharmacology - December 25, 2019 Category: Drugs & Pharmacology Authors: Roselli M, Finamore A Tags: Curr Clin Pharmacol Source Type: research
Drug therapies for patients with IgA nephropathy: A network meta-analysis of randomized clinical trials.
CONCLUSION: We observed few interventions to perform better in the management of IgAN. The results of this study will aid in further evaluation of such drugs that may assist in saving the resources and time. However, the readers should interpret the findings with great caution as the results might change with the advent of future head-to-head clinical trials.
PMID: 31870272 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 21, 2019 Category: Drugs & Pharmacology Authors: Sridharan K, Sivaramakrishnan G Tags: Curr Clin Pharmacol Source Type: research
Prevalence and Predictors of Self-Medication Practices in India: A Systematic Literature Review and Meta-Analysis.
CONCLUSION: Prevalence of self-medication practices are observed quite high in India. While, NSAIDs and anti-allergic are the most frequently utilized self-medicated drugs used for headache and cold & cough.
PMID: 31763976 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 20, 2019 Category: Drugs & Pharmacology Authors: Rashid M, Chhabra M, Kashyap A, Undela K, Gudi SK Tags: Curr Clin Pharmacol Source Type: research
Effects of Probiotics and Prebiotics on Frailty and Ageing: A Narrative Review.
Abstract
Globally, the population over the age of 60 is growing fast, but people age in different ways. Frailty, shown by the accumulation of age-related deficits, is a state of increased vulnerability to adverse outcomes among people of the same chronological age. Ageing results in a decline in diversity and homeostasis of microbiomes, and gut flora changes are related to health deficit accumulation and adverse health outcomes. In older people, health deficits including inappropriate intake, sarcopenia, physical inactivity, polypharmacy, and social vulnerability are factors associated with gut dysbiosis. ...
Source: Current Clinical Pharmacology - November 19, 2019 Category: Drugs & Pharmacology Authors: Jayanama K, Theou O Tags: Curr Clin Pharmacol Source Type: research
Systematic review on rocuronium continuous infusion for deep neuromuscular blockade.
CONCLUSION: Continuous infusion for deep NMB presents inherent advantages in terms of maintenance and stability of the muscle relaxation. For that purpose, monitoring and rocuronium administration approaches are fundamental and intrinsically connected. Additional efforts should be placed in further studies to better understand the variability and methodological parameters for an improved maintenance of deep NMB.
PMID: 31750807 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 19, 2019 Category: Drugs & Pharmacology Authors: Couto M, Couto JG, Nunes CS, Vide S, Amorim P, Mendes JG Tags: Curr Clin Pharmacol Source Type: research
Effects of probiotics in the management of infected chronic wounds: from cell culture to human studies.
CONCLUSIONS: Although preliminary evidence supports the use of specific strains of probiotics in certain clinical settings such as infected chronic wounds, large, long-term clinical trials are still lacking, and further researches are needed .
PMID: 31713496 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 10, 2019 Category: Drugs & Pharmacology Authors: Lorenzo B, Luca S, Antonio M, Alberto DM, Cesare F, Omar C Tags: Curr Clin Pharmacol Source Type: research
Tenofovir urine assay to monitor adherence to HIV pre-exposure prophylaxis (PrEP).
CONCLUSION: The findings of this review confirm the utility of tenofovir urine assay to monitor adherence to HIV pre-exposure prophylaxis. Further studies are underway to implement the tenofovir urine assay to monitor adherence and pre-exposure prophylaxis, nationally and internationally.
PMID: 31713497 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 10, 2019 Category: Drugs & Pharmacology Authors: Moorthy GS, Lalley-Chareczko L, Koenig HC, Zuppa AF Tags: Curr Clin Pharmacol Source Type: research
First-in-Human study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.
CONCLUSION: Single and multiple doses of 2-IB up to 6 doses of 6 mg/kg with and without Captisol® were safe and well tolerated in healthy male subjects. 2-IB proved to be a high-clearance drug with volume of distribution slightly exceeding total body water volume, and with linear PK that appeared not be affected by presence of Captisol®. Sulfobutylether-beta-cyclodextrin (SBECD) in Captisol® had a low-clearance profile with small volume of distribution, with time independent PK. Preliminary PD characterization of repeated iv dosing of 2-IB in an acute peripheral hypoxic ischemia model in healthy subjects did not reveal ...
Source: Current Clinical Pharmacology - October 16, 2019 Category: Drugs & Pharmacology Authors: van Hoogdalem EJ, Peeters-Scholte CMPCD, Leufkens PWTJ, Hartstra J, van Lier JJ, de Leede LGJ Tags: Curr Clin Pharmacol Source Type: research
Formulation and evaluation of polyherbal cream and lotion to treat psoriasis-induced secondary infections.
Conclusion: The present study concluded that most of the formulated lotions and creams showed good antimicrobial activity and may be applied topically against scalp psoriasis.
PMID: 31622222 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - October 16, 2019 Category: Drugs & Pharmacology Authors: Joshi P, Joshi S, Rajani U, Semwal RB, Semwal DK Tags: Curr Clin Pharmacol Source Type: research
Comparative effectiveness of Agmatine and Choline treatment in rats with cognitive impairment induced by AlCl3 and Forced Swim Stress.
CONCLUSION: Present study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements.
PMID: 31622210 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - October 15, 2019 Category: Drugs & Pharmacology Authors: Rafi H, Ahmad F, Anis J, Khan R, Rafiq H, Farhan M Tags: Curr Clin Pharmacol Source Type: research
Severe Group A and Group B Streptococcus diseases at a Pediatric ICU: Are they still sensitive to the penicillins?
CONCLUSIONS: Severe GAS and GBS are rare but associated with high mortality and rates of mechanical ventilation and inotropic supports in PICU. The streptococci are invariably sensitive to penicillin. The high PIM2 and Sepsis scores suggest that prompt recognition of sepsis and timely judicious institution of antibiotics and intensive care support may be life-saving for these devastating infections.
PMID: 31556861 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 25, 2019 Category: Drugs & Pharmacology Authors: Hon KL, Chow TC, Cheung TS, Lam WT, Hung LT, So KW, Ip M, Qian SY Tags: Curr Clin Pharmacol Source Type: research
Efficacy and Safety Curcuma zadoaria L. to inactivate the hydatid cyst protoscoleces.
Abstract
Now, surgery is considered as the most reliable method for hydatid cyst treatment. Present protoscolicidal substances used in operating and percutaneous methods have restrictions because of the severe adverse effects for example biliary tract fibrosis, and liver necrosis. Thus, the present work aimed to evaluate the chemical composition of Curcuma zadoaria essential oil and investigate its efficacy and safety against hydatid cyst protoscoleces. Collected protoscoleces from liver fertile hydatid cysts of infected sheep were exposed to different concentrations of the essential oil (35-280 µl/mL) fo...
Source: Current Clinical Pharmacology - September 17, 2019 Category: Drugs & Pharmacology Authors: Mahmoudvand H, Pakravanan M, Kheirandish F, Jahanbakhsh S, Sepahvand M, Niazi M, Rouientan A, Aflatoonian MR Tags: Curr Clin Pharmacol Source Type: research
Mitochondrial and oxidative impacts of short and long-term administration of HAART on HIV patients.
CONCLUSION: Long-term treatment with HAART increases oxidative stress and causes mitochondrial alterations in HIV patients.
PMID: 31486756 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 4, 2019 Category: Drugs & Pharmacology Authors: Ikekpeazu JE, Orji OC, Uchendu IK, Ezeanyika LUS Tags: Curr Clin Pharmacol Source Type: research
Awareness and perception of thromboembolism and thromboprophylaxis among hospitalized patients in Jordan.
CONCLUSION: The findings reveal that there is a lack of awareness about VTE and its thromboprophylaxis among the study participants. Patients with lower educational level and those with no history of previous VTE need awareness improvement about VTE and its thromboprophylaxis. Clinical Pharmacists need to focus on providing information about VTE and improving patients' perception about VTE and its thromboprophylaxis with the aim of improving the awareness about VTE, and hence improve health outcome.
PMID: 31441731 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 22, 2019 Category: Drugs & Pharmacology Authors: Jarab A, Al-Azzam S, Badaineh R, Mukattash T, Bsoul R Tags: Curr Clin Pharmacol Source Type: research
The New Immunotherapy Combinations in the Treatment of Advanced Non-Small Cell Lung Cancer: Reality and Perspectives.
CONCLUSION: Nivolumab plus ipilimumab represent the most promising immunotherapy combination for the treatment of advanced NSCLC patients; safety, tolerability and efficacy of new immune modulators (in monotherapy and in immune combinations) must be further assessed in future studies.
PMID: 31400270 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 8, 2019 Category: Drugs & Pharmacology Authors: Rocco D, Gravara LD, Gridelli C Tags: Curr Clin Pharmacol Source Type: research
