Trends of Clinical Trials for Drug Development in Rare Diseases.
CONCLUSION: This study revealed details of the three registries and bias among rare diseases in the number of the trials. This information could contribute to drug-repositioning and a broad range of rare disease studies.
PMID: 29866013 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 3, 2018 Category: Drugs & Pharmacology Authors: Sakate R, Fukagawa A, Takagaki Y, Okura H, Matsuyama A Tags: Curr Clin Pharmacol Source Type: research
Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients With Non-Hodgkin Lymphoma.
CONCLUSION: B-lymphocyte depletion following blinatumomab infusion was exposure-dependent. Transient cytokine elevation increased with dose; it was less pronounced at low starting dose. Tumor response was a function of exposure, suggesting utility for the PK/PD relationship in dose selection for future studies, including NHL and other malignant settings.
PMID: 29773068 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 17, 2018 Category: Drugs & Pharmacology Authors: Hijazi Y, Klinger M, Kratzer A, Wu B, Baeuerle PA, Kufer P, Wolf A, Nagorsen D, Zhu M Tags: Curr Clin Pharmacol Source Type: research
Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model.
Abstract
The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation were determined. Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 μg/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of g...
Source: Current Clinical Pharmacology - May 15, 2018 Category: Drugs & Pharmacology Authors: Pourahmad J, Salimi A, Razian M Tags: Curr Clin Pharmacol Source Type: research
The effect of tranexamic acid on preventing post-partum hemorrhage due to uterine atony: a triple-blind randomized clinical trial.
CONCLUSION: The results of the present study showed that administrating intravenous TXA had comparable effects with prostaglandin analogue on reducing PPH in women with uterine atony and in those undergoing C section or vaginal delivery. Therefore, TXA can be used instead of prostaglandin in managing such patients.
PMID: 29732978 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 6, 2018 Category: Drugs & Pharmacology Authors: Zargar M, Nikbakht R, Ahmadi M Tags: Curr Clin Pharmacol Source Type: research
Targeting Brain Tumors with Nanomedicines: Overcoming Challenges of Blood Brain Barrier.
Abstract
This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the Blood brain barrier (BBB) / blood-brain tumor barrier (BTB) to kill tumor cells and impact patient survival. We highlighted various advances in understanding the mechanism of BTB function that impact on anticancer therapeutics delivery. We discussed latest breakthroughs in developing pharmaceutical strategies, including nanomedicines and delivering them across BTB for brain tumor management and treatment. We highlight various st...
Source: Current Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: Ningaraj NS, Reddy PL, Khaitan D Tags: Curr Clin Pharmacol Source Type: research
Phase IV Studies: Some Insights, Clarifications, And Issues.
CONCLUSIONS: Critical remarks are raised against the pure commercial perspective in the proposal of PASS and PAES and on the design of registries which should be mainly based on the objectives and the planned analyses, as it has reported in the study protocol. Finally, a particular focus is also placed on the work of the Ethical Committees regarding the approval of the observational studies on the safety and the efficacy of the drugs in their pragmatic clinical use.
PMID: 29651962 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: Biganzoli EM, Cesana BM Tags: Curr Clin Pharmacol Source Type: research
Lupus Nephritis: A Treatment Update.
CONCLUSION: Lupus nephritis which does not respond to initial treatment is associated with worse renal outcomes. Several therapeutic approaches are available for the induction and maintenance immunosuppression of the different classes of LN. Management of LN should be individualized for each patient based on their risk-benefit profile.
PMID: 29611488 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 3, 2018 Category: Drugs & Pharmacology Authors: Aziz F, Chaudhary K Tags: Curr Clin Pharmacol Source Type: research
Hepatic Elimination of Drugs in Gestational Diabetes.
CONCLUSION: Considering the frequency of the disease and the effects that these pharmacokinetic changes might have on the mother and child, the need for further research seems advisable. In the meantime, cautious clinical judgment in the management of drug administration in women affected by this disease is recommended.
PMID: 29577863 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 25, 2018 Category: Drugs & Pharmacology Authors: Gonzalez CD, Alvarinas J, Bolanos R, Di Girolamo G Tags: Curr Clin Pharmacol Source Type: research
Formulation of herbal fast disintegrating tablets and its ex-vivo study for anti-histaminic activity in guinea pig ileum.
CONCLUSION: On the basis of in-vitro and ex-vivo studies, it was concluded that prepared herbal fast disintegrating tablets were stable and had potent antihistaminic activity.
PMID: 29521214 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 9, 2018 Category: Drugs & Pharmacology Authors: Puri D, Bhandari A, Gaur PK, Yasir M, Kumar SS, Choudhary D Tags: Curr Clin Pharmacol Source Type: research
Knowledge, attitudes, and practices of pharmacovigilance and ADRs spontaneous reporting among pediatricians and pediatric residents in Jordan.
CONCLUSION: The results of the present study reveals that pediatricians lack knowledge of PV and ADRs reporting. However, they have a good attitude towards ADRs reporting and enhancing their PV practice. This is still not reflected in their own practice. Further training and education about ADRs reporting is very important to move toward safer medications in children.
PMID: 29521246 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 8, 2018 Category: Drugs & Pharmacology Authors: Mukattash TL, Alwadi MW, Abu-Farha RK, Jarab A, Alzubiedi SA, Alwedyan T Tags: Curr Clin Pharmacol Source Type: research
Determination of parameters of oxidative stress in vitro models of neurodegenerative diseases-A review.
Abstract
Oxidative stress is a major mechanism underlying the development of various neurodegenerative diseases (Alzheimer, Parkinson, Huntington and amyotrophic lateral sclerosis). Excessive formation of reactive oxygen species (ROS) and nitrogen (RNSs) can overburden the ability of the enzymatic antioxidant defense mechanisms (superoxide dismutase, catalase and glutathione reductase) and non-enzymatic (uric acid, ascorbic acid, α-tocopherol and reduced glutathione) causing the development of oxidative stress and consequently impairing the neuronal system cells by means of oxidative damage to a variety o...
Source: Current Clinical Pharmacology - February 28, 2018 Category: Drugs & Pharmacology Authors: Feitosa CM Tags: Curr Clin Pharmacol Source Type: research
More Evidence For The Therapeutic Role Of Dopamine Agonists In Upper Limb Restlessness Due To Cervical Disc Pathology?
Abstract
BACKGROUND: The causal link between upper limb restlessness and cervical disc prolapsus is still unclear, and the exact role of the spinal cord in the origination of limb restlessness is not yet completely understood.
METHODS: Here we have evaluated the therapeutic effect of pramipexole (0.5 mg/kg) in a 47-year old male with cervical disc prolapsus who described restlessness in his upper limb and neck.
RESULTS: The patient felt significantly better, and his symptoms improved near to complete after five days after we have initiated 0.5 mg/day pramipexole treatment. Conclussion: In o...
Source: Current Clinical Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Yulug B, Brandmeier S, Hanoglu L Tags: Curr Clin Pharmacol Source Type: research
Minocycline in alcohol withdrawal induced anxiety and alcohol relapse in rats.
CONCLUSION: Minocycline attenuates alcohol withdrawal anxiety and disrupts alcohol relapse.
PMID: 29493462 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Gajbhiye SV, Tripathi RK, Petare AU, Potey AV, Shankar A Tags: Curr Clin Pharmacol Source Type: research
An Evidence-Based Review of Off-Label Uses of Polidocanol.
CONCLUSION: Numerous successful administrations of this drug in a variety of clinical conditions lead to promising perspectives toward it. Sclerotherapy with polidocanol as a minimal-invasive method (having similar outcomes like the prevalent surgeries) may reduce the rate of complications. Furthermore, for determining the most appropriate method and dosage, randomized clinical trials are needed, confirming and providing more clear instructions for different conditions.
PMID: 29473522 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 23, 2018 Category: Drugs & Pharmacology Authors: Babaei H, Enamzadeh E Tags: Curr Clin Pharmacol Source Type: research
Drug-induced QT Interval prolongation in the Intensive Care Unit.
Abstract
Drug-induced QT interval prolongation is the most frequent cause of Long QT syndrome (LQTS) in the clinical practice. This electrophysiological entity, produced by an extended duration of the myocardial repolarization and reflected as a prolonged QT interval in the superficial electrocardiogram (EKG), increases the risk of polymorphic ventricular tachycardia (Torsades de Pointes) appearance and sudden death. Certain antiarrhythmic drugs such as amiodarone, sotalol, quinidine, procainamide, verapamil and diltiazem are known as drugs that, due to their mechanism of action, prolong the QT interval, d...
Source: Current Clinical Pharmacology - February 23, 2018 Category: Drugs & Pharmacology Authors: Etchegoyen CV, Keller GA, Mrad S, Cheng S, DiGirolamo G Tags: Curr Clin Pharmacol Source Type: research
