Pharmacogenetics of Glucagon-like Peptide-1 agonists for the treatment of Type 2 Diabetes Mellitus.
CONCLUSION: Although the exact DNA sequences that cause the molecular changes leading to a variable response to GLP-1 agonists have not been yet fully identified, these findings underline the importance of an individualized approach in anti-diabetic treatment.
PMID: 29473524 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 21, 2018 Category: Drugs & Pharmacology Authors: Karras S, Rapti E, Koufakis T, Kyriazou A, Goulis D, Kotsa K Tags: Curr Clin Pharmacol Source Type: research
Strategies empowering paediatric drug safety.
Conclusion Together, these methods provide a comprehensive picture of causality and risk improving the management of therapy in a paediatric setting and they should be considered as a unique tool to be integrate with post-marketing activities.
PMID: 29412117 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 6, 2018 Category: Drugs & Pharmacology Authors: Gentili M, Pozzi M, Peeters G, Radice S, Carnovale C Tags: Curr Clin Pharmacol Source Type: research
Evaluation of the Antiproliferative Activity of Some Nanoparticulate Essential Oils Formulated in Microemulsion on Selected Human Carcinoma Cell Lines.
CONCLUSION: Some EOs and their microemulsions can potentially be used as natural adjuvant to cancer drugs.
PMID: 29318975 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 10, 2018 Category: Drugs & Pharmacology Authors: Abd-Rabou A, Edris AE Tags: Curr Clin Pharmacol Source Type: research
Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.
CONCLUSION: Curcumin supplementation increased adiponectin, whilst the the leptin:adiponectin ratio (a measure of atherosclerosis) and leptin levels were decreased independent of weight change and reflected a decrease in the inflammatory TNF-α levels.
PMID: 29299989 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 3, 2018 Category: Drugs & Pharmacology Authors: Sahebkar A, Panahi Y, Khalili N, Sahebi E, Namazi S, Atkin SL, Majeed M Tags: Curr Clin Pharmacol Source Type: research
Comparison of Two Naloxone Regimens in Addicted Methadone-Overdosed Patients, a Clinical Trial Study.
CONCLUSION: It seems that gradual titration of naloxone by Tintinalli protocol can reduce major complications compared to the Goldfrank regimen. However, this protocol was not perfect in reducing complications in opioid-dependent methadone-overdosed patients, either. We may need different protocols in opioid-dependent and opioid-naive patients.
PMID: 29231146 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 11, 2017 Category: Drugs & Pharmacology Authors: Khosravi N, Zamani N, Hassanian-Moghaddam H, Ostadi A, Rahimi M, Kabir A Tags: Curr Clin Pharmacol Source Type: research
