Cadazolid vs Vancomycin for Treatment of Clostridioides difficile Infection: Systematic Review with Meta-Analysis.
CONCLUSION: Cadazolid is non-inferior to vancomycin and offers a promising alternative for the treatment of CDI.
PMID: 31376824 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 1, 2019 Category: Drugs & Pharmacology Authors: Aziz M, Simcha W, Fatima R, Rajani S, Eid A, Nawras A Tags: Curr Clin Pharmacol Source Type: research
A review of the role of statins in heart failure treatment.
Abstract
Heart failure is a common medical problem in the world, which has a high prevalence in both developed and developing countries. Today, among the medications used for the heart failure treatment, there are many medications with a positive cardiac contraction effect (positive inotropic such as digital glycosides, adrenergic receptor stimulants, and phosphodiesterase inhibitors), a large number of cardiac diluents (such as Angiotensin-converting enzyme (ACE) inhibitor group), and a few other types of drugs whose final effects are still under review Statins are valuable drugs that are broadly prescrib...
Source: Current Clinical Pharmacology - August 1, 2019 Category: Drugs & Pharmacology Authors: Niazi M, Galehdar N, Jamshidi M, Mohammadi R, Moayyedkazemi A Tags: Curr Clin Pharmacol Source Type: research
Oral and intranasal administration of nanoparticles in the cerebral ischemia treatment; Considering the advantages and disadvantages.
CONCLUSION: Despite the limitations of oral and intranasal routes, the therapeutic potential of oral and intranasal administration of Nano-medicines is high in cerebral ischemia treatment.
PMID: 31272358 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - July 3, 2019 Category: Drugs & Pharmacology Authors: Alavian F, Shams N Tags: Curr Clin Pharmacol Source Type: research
Comparison of the mean minimum dose of bolus oxytocin for proper uterine contraction during cesarean section.
CONCLUSION: Since the minimum effective dose of oxytocin in elective cesarean section was 1IU, and in those in labor progress was 1-1.5IU, less oxytocin administration represent a lesser side effect for the patients. It is recommended that patients who are candidates for cesarean section should be administered with about 1.5IU of oxytocin in the form of bolus.
PMID: 31124424 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 22, 2019 Category: Drugs & Pharmacology Authors: Beiranvand S, Karimi A, Vahabi S, Amin-Bidokhti A Tags: Curr Clin Pharmacol Source Type: research
Melatonin modulates regulation of NOX2 and NOX4 following irradiation in the lung.
CONCLUSION: It is possible that upregulation of NOX2 and NOX4 are involved in radiation-induced targeted and non-targeted lung injury. Melatonin may reduce oxidative stress following upregulation of these enzymes in direct irradiated lung tissues but not for bystander.
PMID: 31057124 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 1, 2019 Category: Drugs & Pharmacology Authors: Najafi M, Shirazi A, Motevaseli E, Geraily G, Amini P, Tooli LF, Shabeeb D Tags: Curr Clin Pharmacol Source Type: research
Medication Management Issues in Old Age: A Call for Submissions to Current Clinical Pharmacology.
PMID: 30968764 [PubMed - in process] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 12, 2019 Category: Drugs & Pharmacology Authors: Mangoni AA, Bryant K, Jarmuzewska EA Tags: Curr Clin Pharmacol Source Type: research
Science-Based Ethnic Bridging in Drug Development; Review of Recent Precedence and Suggested Steps Forward.
CONCLUSIONS: Recent precedence reflected a pragmatic, descriptive approach of racial or ethnic bridging, apparently meeting current regulatory expectations, whilst not resulting in strict guidance to prescribers. Next steps: We recommend further work on defining the objectives of bridging studies, as well as criteria for their design and data analysis. Regarding the latter we recommend investigating the value of prospectively defined tests for similarity with appropriate follow-up analysis in the case where the test has failed.
PMID: 30961506 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 7, 2019 Category: Drugs & Pharmacology Authors: van Hoogdalem EJ, Jones JP, Constant J, Achira M Tags: Curr Clin Pharmacol Source Type: research
Concomitant use of Cotrimoxazole and Atazanavir in HIV-infected patients: A Therapeutic Drug Monitoring and Pharmacovigilance based dual approach.
CONCLUSION: This study showed a relevant concomitant use between Cotrimoxazole and ATV based on TDM and PV approaches.
PMID: 30961507 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 4, 2019 Category: Drugs & Pharmacology Authors: Joe MB, Rolandc L, Laurentg C, Patrick LM, Sawoo O, Gastonf TL, Brunoe E, Gilles P, Philippe P Tags: Curr Clin Pharmacol Source Type: research
Surotomycin (a novel cyclic lipopeptide) vs Vancomycin for treatment of Clostridioides difficile infection: A systematic review and Meta-analysis.
CONCLUSION: Surotomycin is non-inferior to vancomycin and offers a promising alternative for the treatment and prevention of C. diff infection. .
PMID: 30924421 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 27, 2019 Category: Drugs & Pharmacology Authors: Aziz M, Desai M, Fatima R, Chandrasekar VT, Eid A, Jackson M, Sharma P Tags: Curr Clin Pharmacol Source Type: research
Comparison of efficacy of remifentanil, sufentanil and alfentanil with fentanyl when combined with propofol for general anesthesia: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: To conclude, we found that remifentanil has a statistically significant anesthetic profile than fentanyl when combined with propofol. Scanty evidence for both alfentanil and sufentanil precludes any such confirmation.
PMID: 30868958 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 12, 2019 Category: Drugs & Pharmacology Authors: Sridharan K, Sivaramakrishnan G Tags: Curr Clin Pharmacol Source Type: research
A Comprehensive Review On the Screening Models for The Pharmacological Assessment of Antiulcer Drugs.
CONCLUSION: On the basis of our study, we found some useful models for the antiulcer activity of drugs and we suggest that if we use In-vitro and In-vivo methods together, then, we get the most relevant result in our research area.
PMID: 30864527 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 11, 2019 Category: Drugs & Pharmacology Authors: Mishra AP, Bajpai A, Chandra S Tags: Curr Clin Pharmacol Source Type: research
Investigation of the roles of new antiepileptic drugs' and serum BDNF levels in efficacy and safety monitoring and quality of life: a clinical research.
Abstract
OBJECTIVE: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to brain-derived neurotropic factor (BDNF) of frequently used new antiepileptic drugs (NAD) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). Moreover, we investigated their effect on the quality of life (QoL).
METHODS: Eighty epileptic patients who had been using the NAD, thirteen healthy participants were included in this cross-sectional study. The participants were randomized to groups. The QOLIE-31 test was used for the assessment of QoL. We also prepa...
Source: Current Clinical Pharmacology - March 11, 2019 Category: Drugs & Pharmacology Authors: Demir M, Akarsu EO, Dede HÖ, Bebek N, Yıldız SÖ, Baykan B, Akkan AG Tags: Curr Clin Pharmacol Source Type: research
Azithromycin-induced aphthous stomatitis: a case series.
CONCLUSION: It could be stated that aphthous stomatitis is an important adverse effect of azithromycin that can affect the patient's quality of life during therapy and in the majority of cases, it can be neglected by healthcare practitioners.
PMID: 30827258 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 28, 2019 Category: Drugs & Pharmacology Authors: Moghadam ET, Tafazoli A Tags: Curr Clin Pharmacol Source Type: research
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy.
Abstract
Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. In this respect, there are no cases of successful clinical application of such candidate molecules when it comes to human patients. To address this problem, we tested minocycline in an in-vitro model of laser-axotomy. Here, we have shown that minocycline exerted a significant neuroprotective effect at 1 and 100μM doses. Beyond confirming the neuroprotective effect of minocyc...
Source: Current Clinical Pharmacology - February 24, 2019 Category: Drugs & Pharmacology Authors: Yulug B, Ozansoy M, Alokten M, Ozansoy MBC, Cankaya S, Hanoglu L, Kilic U, Kilic E Tags: Curr Clin Pharmacol Source Type: research
Impact of ondansetron on withdrawal signs, fentanyl requirement and pain relief in opioid addicted patients under general anesthesia.
CONCLUSION: This study demonstrated a few evidence for beneficial treatment of ondansetron for control of withdrawal symptoms and pain in addicted patients, and more clinical studies are suggested in this regard.
PMID: 30706788 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Authors: Mahikhan F, Hashemian M, Dehesh T, Jafari E, Jafari M, Rahimi HR Tags: Curr Clin Pharmacol Source Type: research
