Biosimilars: an approach to current worldwide regulation frameworks.
Abstract
Developing new biological medicaments has led to the regulations and norms regarding such drugs, in terms of marketing, prescription, use, interchangeability and switching, have become fundamental aspects guaranteeing their safety, quality and effectiveness. Biologics are of great importance in treating patients suffering rheumatic, autoimmune, inflammatory, neoplastic and other diseases. The expiry/lapse of reference biologics or originators' patents has meant that developing biosimilars needs accompanying legal requirements for their approval in countries worldwide. This paper has thus been aime...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Esteban E, Bustos RH, García JC, Jauregui E Tags: Curr Clin Pharmacol Source Type: research
Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization.
Abstract
Nowadays, ionizing radiation is used for several applications in medicine, industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing radiation, there are some concerns for accidental exposure to radioactive sources. The threat posed by its use in terrorism is of global concern. Furthermore, there are several side effects to normal organs for patients had undergone radiation treatment for cancer. Hence, modulation of radiation response in normal tissues was one of the most important aims of radiobiology. Although, so far, several agents have been investigated for...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Mortezaee K, Shabeeb D, Musa AE, Najafi M, Farhood B Tags: Curr Clin Pharmacol Source Type: research
Efficacy Of Zofenopril Alone Or In Combination With Hydrochlorothiazide In Patients With Kidney Dysfunction.
Abstract
Hypertension and kidney disease often coexist, further increasing the risk of future cardiovascular events. Treatment of hypertensive adults with an angiotensin converting enzyme inhibitor in case of concomitant kidney disease may slow disease progression. The third-generation liphophilic angiotensin converting enzyme inhibitor zofenopril, administered alone or combined with a thiazide diuretic, has proved to be effective in lowering blood pressure in hypertensive patients and to reduce the risk of fatal and non-fatal events in post-acute myocardial infarction and heart failure. In almost three-hu...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Omboni S, Borghi C Tags: Curr Clin Pharmacol Source Type: research
Anaemogenic, Obesogenic And Thermogenic Potentials Of Graded Doses Of Monosodium Glutamate Sub-Acutely Fed To Experimental Wistar Rats.
CONCLUSION: The current data suggest that consumption of high doses/quantity of monosodium glutamate for a long duration of time could lead to anaemia due to decrease in red blood cell count and packed cell volume and obesity resulting from increase in body.
PMID: 30277163 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - October 2, 2018 Category: Drugs & Pharmacology Authors: Salisu N, Aliyu FS, Garba H, Garba MH Tags: Curr Clin Pharmacol Source Type: research
Preface: Vitamin D and QT Interval in Epilepsy: More than an Association?
PMID: 30175694 [PubMed - in process] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 5, 2018 Category: Drugs & Pharmacology Authors: Mangoni AA, Jarmuzewska EA Tags: Curr Clin Pharmacol Source Type: research
Interventions for improving bone mineral density and reducing fracture risk in osteogenesis imperfecta: A mixed treatment comparison network meta-analysis of randomized controlled clinical trials.
CONCLUSION: Oral bisphosphonates and teriparatide significantly increase BMD but are not associated with fracture risk reduction. Of the available interventions, oral bisphosphonates could perform better than others in osteogenesis imperfecta. This evidence should be considered preliminary and may change with future head-to-head clinical trials.
PMID: 30160216 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 29, 2018 Category: Drugs & Pharmacology Authors: Sridharan K, Sivaramakrishnan G Tags: Curr Clin Pharmacol Source Type: research
Lipid-based siRNA Nanodelivery Systems: a Learning Process for Improving Transfer from Concepts to Clinical Applications.
CONCLUSION: Formulation design should be increasingly addressed with industrial criteria; it should be based on quality by design and on the estimation of critical attributes that affect performance, and supported by a range of characterization techniques and appropriate analytical methods.
PMID: 30160217 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 29, 2018 Category: Drugs & Pharmacology Authors: Perez SE, Carlucci AM Tags: Curr Clin Pharmacol Source Type: research
Evaluation the effects of oral and topical simvastatin as adjunct therapy in the treatment of acne vulgaris.
CONCLUSION: Although preliminary, the results of this study showed that oral and topical statins, agents with anti-inflammatory properties, can be considered as effective treatment for acne vulgaris adjunct to standard treatment. However, further studies with larger sample size and longer follow-up are needed to confirm these results.
PMID: 30129417 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 21, 2018 Category: Drugs & Pharmacology Authors: Ahmadvand A, Yazdanfar A, Yasrebifar F, Mohammadi Y, Mahjoub R, Mehrpooya M Tags: Curr Clin Pharmacol Source Type: research
Therapeutic Approach for Irritable Bowel Syndrome: Old and New Strategies.
CONCLUSIONS: The treatment of IBS remains focused on treating the patient's predominant, or most troublesome, symptoms. New promising treatments have recently become available for the treatment of IBS but long term studies are still needed.
PMID: 30084333 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Usai-Satta P, Bellini M, Lai M, Oppia F, Cabras F Tags: Curr Clin Pharmacol Source Type: research
A recent update on the effects of omega-3 fatty acids in Alzheimer's disease.
Abstract
Dietary long chain polyunsaturated fatty acids belong to omega (ω)-3, -6 or -9 series. Both experimental and clinical studies demonstrated the beneficial effect of ω -3 fatty acids of fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) against human ailments including cardiovascular diseases and rheumatoid arthritis. They are metabolized in cyclooxygenase and lipooxygenase pathways and also by cytochrome P450 isozymes. Biological importance of DHA in the development of brain and retina are established as well. Recent studies highlighted the beneficial effect of ω-3 fatty acids ...
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Ajith TA Tags: Curr Clin Pharmacol Source Type: research
SGLT-2 inhibitors in type 1 diabetes mellitus: a comprehensive review of the literature.
CONCLUSION: This novel class of antidiabetics seems to be a very attractive treatment option in patients with T1DM, due to their multiple beneficial effects, but the increased risk of DKA should be taken into account.
PMID: 30084335 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Patoulias D, Imprialos K, Stavropoulos K, Athyros V, Doumas M Tags: Curr Clin Pharmacol Source Type: research
How to design and validate a questionnaire: A guide.
CONCLUSION: Since it is equally important to verify the usefulness of the designed questionnaire, the article briefly describes the process of psychometric evaluation of a questionnaire.
PMID: 30084336 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Sidhu JK, Singh S, Kathuria P Tags: Curr Clin Pharmacol Source Type: research
Differentially enhancing effects of long-term treatment with Serrazyme, Boswellia and Pine on seminal bacterial detection in patients with chronic bacterial or inflammatory prostatitis, probably related to several degrees of bacterial adherence.
CONCLUSION: The results of the present study showed that 2 months of treatment with PEM, decreasing bacterial adherence and inflammatory prostatitis, reveals a subgroup of apparent inflammation associated with infection that microbial biofilms likely mask in inflammatory prostatitis patients.
PMID: 30073929 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 2, 2018 Category: Drugs & Pharmacology Authors: Vicari E, Malaguarnera G, Vicari BO, Salmeri M, Salemi M, Castiglione R Tags: Curr Clin Pharmacol Source Type: research
Antibody-Drug Conjugates: A Review on the Epitome of Targeted Anti-Cancer Therapy.
Abstract
Cancer is one of the deadly diseases which is characterized by unchecked cell division or abnormal cell growth due to the incapability of cell cycle arrest. As the treatment for this is to kill the cancerous cells the main challenge for scientists is to direct the cell killing to cancerous cells while leaving the normal cells unharmed. Antibody-drug conjugates (ADC) are one such targeted anti-cancer therapy. It is an effective drug delivery system that utilizes the targeting action of antibody along with cell death by potent cytotoxic agent, linked up with one another by a linker molecule and thus...
Source: Current Clinical Pharmacology - August 1, 2018 Category: Drugs & Pharmacology Authors: Hasan M, Alam S, Poddar SK Tags: Curr Clin Pharmacol Source Type: research
Nanovehicle-based small interfering RNA (siRNA) delivery for therapeutic purposes: a new molecular approach in the pharmacogenomics.
Abstract
RNA interference (RNAi) is a process for regulating the gene expression in which small interfering RNAs (siRNAs) silence target genes. siRNA-based therapy as a new molecular treatment approach, offers therapeutic prospects for many common diseases such as cancer and cardiovascular disorders. Nevertheless, the efficacy of siRNA delivery has, so far, remained a challenging issue. This is due to their easy degradation through the circulation system and the difficulties in the intracellular delivery to specific tissues where they silence the target genes. There have been many efforts to develop suitab...
Source: Current Clinical Pharmacology - July 9, 2018 Category: Drugs & Pharmacology Authors: Akhtari J, Tafazoli A, Mehrad-Majd H, Mahrooz A Tags: Curr Clin Pharmacol Source Type: research
