Drug-Induced Peripheral Neuropathy, a Narrative Review.
Abstract
Peripheral neuropathy is a painful condition deriving from many and varied etiologies. Certain medications have been implicated in the iatrogenic development of drug induced peripheral neuropathy (DIPN) and include chemotherapeutic agents, antimicrobials, cardiovascular drugs, psychotropic, anticonvulsants, among others. In many cases, DIPN develops in a dose dependent fashion following continued use of a neurotoxic agent. The development of DIPN should be suspected in patients who are receiving drug treatment and report new onset symptoms of pain, paresthesia, or weakness. In patients in whom a h...
Source: Current Clinical Pharmacology - January 21, 2019 Category: Drugs & Pharmacology Authors: Jones MR, Urits I, Wolf J, Corrigan D, Colburn L, Peterson E, Williamson A, Viswanath O Tags: Curr Clin Pharmacol Source Type: research
Efficacy and safety of Nilutamide in patients with metastatic prostate cancer who underwent orchiectomy: A systematic review and meta-analysis.
CONCLUSION: Evidence suggests that patients with mPCa who underwent orchiectomy receiving Nilutamide showed significant improvement in progression-free survival and overall survival response rate and clinical benefits in comparison with the placebo group.
PMID: 30648519 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 12, 2019 Category: Drugs & Pharmacology Authors: Rashid M, Shamshavali K, Chhabra M Tags: Curr Clin Pharmacol Source Type: research
The Effect of methylphenidate on Reed Scaling in Benzodiazepine Poisoning, A Prospective Trial.
CONCLUSION: Our study provided the MPH superiority over PBO in reversing CNS symptoms in loss of consciousness in acute BZD poisoned patients. Thus, this trial provides concrete evidence that improvement in consciousness levels (Reed Scale rated) among those patients receiving MPH was associated with a methylphenidate use.
PMID: 30648520 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 12, 2019 Category: Drugs & Pharmacology Authors: Latifi-Pour M, Hassanian-Moghaddam H, Mortazavi HS, Shadnia S, Zamani N, Rahimi M Tags: Curr Clin Pharmacol Source Type: research
The possibility of therapeutic drug monitoring of the most important interactions in nursing homes.
CONCLUSION: In this pilot study, therapeutic drug monitoring was possible in the majority of the most important interactions in Norwegian nursing homes. This is option is of importance since adjust dose or monitoring were frequently recommended actions associated with these interactions.
PMID: 30585548 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 24, 2018 Category: Drugs & Pharmacology Authors: Schjøtt P, Šutovská M, Schjøtt J Tags: Curr Clin Pharmacol Source Type: research
Metformin And Pregnancy Outcomes: Evidence Gaps And Unanswered Questions.
CONCLUSIONS: It seems to have no sense to prolong the use of metformin after a pregnancy diagnosis in women with PCOS. Patients with GDM may be treated with metformin under on judicious basis, and a careful attachment to clinical guidelines and regulations is recommended. The long-term effects of pre-natal exposure to metformin on the offspring remain uncertain.
PMID: 30585549 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 24, 2018 Category: Drugs & Pharmacology Authors: Gonzalez CD, Alvariñas J, Bagnes MFG, Di Girolamo G Tags: Curr Clin Pharmacol Source Type: research
Protective effect of Selenium-L-methionine on radiation-induced acute pneumonitis and lung fibrosis in rat.
CONCLUSION: Selenium-L-methionine can protect lung tissues against toxic effects of ionizing radiation. It is possible that modulation of immune responses and redox interactions are involved in the radioprotective effect of this agent.
PMID: 30556505 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 13, 2018 Category: Drugs & Pharmacology Authors: Amini P, Kolivand S, Saffar H, Rezapoor S, Motevaseli E, Najafi M, Nouruzi F, Shabeeb D, Musa AE Tags: Curr Clin Pharmacol Source Type: research
Role of muscarinic acetylcholine receptors in Breast Cancer. Design of metronomic chemotherapy.
CONCLUSION: The usage of subthreshold concentrations of muscarinic agonists combined with conventional chemotherapeutic agents could be a promising tool for breast cancer therapy.
PMID: 30501602 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 2, 2018 Category: Drugs & Pharmacology Authors: Sales ME, Español AJ, Salem AR, Martínez PP, Sanchez Y, Sanchez F Tags: Curr Clin Pharmacol Source Type: research
Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice.
CONCLUSION: Thus pycnogenol has a protective approach towards the convulsion and can be included as an adjuvant therapy with antiepileptic drugs.
PMID: 30465512 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 21, 2018 Category: Drugs & Pharmacology Authors: Goel R, Saxena P Tags: Curr Clin Pharmacol Source Type: research
Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles.
CONCLUSION: The study revealed that oral administration of rHuKGF-loaded CNPs in methacrylic acid-methyl methacrylate copolymer-coated capsules is practically alternative to the IV administration since the absolute bioavailability of the orally administered rHuKGF-loaded CNPs, using rabbit as animal model, was 69%. Fluorescent microscope imaging revealed that rhodamine-labelled rHuKGF-loaded CNPs were taken up by FHs 74 Int cells, after 6 hours' incubation time, followed by increase in the proliferation rate.
PMID: 30457053 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 19, 2018 Category: Drugs & Pharmacology Authors: Kumar PV, Maki MAA, Wei YS, Tatt LM, Elumalai M, Cheah SC, Raghavan B, Majeed ABBA Tags: Curr Clin Pharmacol Source Type: research
The Ascent of Mineralocorticoid Receptor Antagonists in Diabetic Nephropathy.
Abstract
Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone esc...
Source: Current Clinical Pharmacology - November 15, 2018 Category: Drugs & Pharmacology Authors: Goenka L, Padmanaban R, George M Tags: Curr Clin Pharmacol Source Type: research
Desensitization Of 5-Ht-1a Somatodentritic Receptors In Tryptophan Treated And Co-Treated Rats Induced By Methylphenidate.
CONCLUSION: Present study suggests the potential of tryptophan to decrease the risk of behavioral sensitization induced by methylphenidate.
PMID: 30417792 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Farhan M, Riaz F, Wali S, Rafiq H Tags: Curr Clin Pharmacol Source Type: research
Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity.
Conclusion MDIS occurs by a nonimmune mechanism which requires a prompt withdrawal of the offending drug(s), and in some cases may require drug re-challenge and desensitization.
PMID: 30417793 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Behera SK, Das S, Chengappa KG, Xavier AS, Selvarajan S Tags: Curr Clin Pharmacol Source Type: research
The cytotoxicity and synergistic potential of aspirin and aspirin analogues towards oesophageal and colorectal cancer.
CONCLUSION: These findings indicate the potential and limitations of aspirin and aspirin analogues as chemotherapeutic agents against OC and CRC when combined with platins.
PMID: 30417794 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Kilari RS, Bashir AIJ, Devitt A, Perry CJ, Safrany ST, Nicholl ID Tags: Curr Clin Pharmacol Source Type: research
The added value of liquid antipsychotics: the case of quetiapine.
CONCLUSION: The liquid form of quetiapine can facilitate pharmacotherapy of schizophrenia and it can be defined as value added medicine bringing key benefits for the patients, the caregivers but also for the health care system.
PMID: 30387400 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 2, 2018 Category: Drugs & Pharmacology Authors: Papazisis G, Siafis S Tags: Curr Clin Pharmacol Source Type: research
A critique on computer simulation software's used in pharmacokinetics and pharmacodynamics analysis.
Abstract
Computer has wide applicability in many field, and in pharmaceutical science the computer play a crucial role as a commander of all the theoretical aspects and provide a workbench to improve the overall quality system of the pharmaceutical research and development. The aim of this article is to provide computational approach in development of the many booming technology of computer software in the field of clinical pharmacokinetics. The computational technique practiced by clinical pharmacist and scientist with the applied knowledge and skills of dealing with clinical pharmacokinetics problems, wh...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Dave V, Yadav RB, Yadav S, Sharma S, Sahu RK, Ajayi AF Tags: Curr Clin Pharmacol Source Type: research
