Warburg effects on cancer cells survival: the role of sugar starvation in cancer therapy.
CONCLUSION: As cancer cells use glucose for aerobic glycolysis as a preferred substrate for energy yielding metabolism, we discuss in this review the Warburg effect and a strategy of starving cancer from glucose to prevent cancer cell survival and induce apoptosis in various types of cancer which could be the key to future treatment.
PMID: 32282309 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 12, 2020 Category: Drugs & Pharmacology Authors: Zam W, Ahmed I, Yousef H Tags: Curr Clin Pharmacol Source Type: research
Effect of chamomile oil on cesarean section pain in primiparous women: a randomized clinical trial.
CONCLUSION: According to the results of the present study, inhalation of chamomile oil following caesarean section in primiparous women reduced pain and also the need for analgesics. Therefore, the use of aromatherapy with chamomile oil as a simple way without any side effects for the reduction of pain in mothers after cesarean section is recommended.
PMID: 32228427 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 30, 2020 Category: Drugs & Pharmacology Authors: Zardosht R, Basir A, Sahebkar A, Emami SA Tags: Curr Clin Pharmacol Source Type: research
Experimental phage therapies in companion animals with historical review.
CONCLUSIONS: The effectiveness of phages therapies depends on many factors and the properties of the bacteriophages themselves, which requires comprehensive knowledge of them.
PMID: 32223736 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 28, 2020 Category: Drugs & Pharmacology Authors: Pyzik E, Urban-Chmiel R, Radzki RP Tags: Curr Clin Pharmacol Source Type: research
Prebiotics and Probiotics in Inflammatory Bowel Disease (IBD): Where Are We Now And Where Are We Going?Funders.
Abstract
The incidence, prevalence, and cost of care associated with diagnosis and management of inflammatory bowel disease are on the rise. The role of gut microbiota in the causation of Crohn's disease and ulcerative colitis has not been established yet. Nevertheless, several animal models and human studies point towards the association. Targeting intestinal dysbiosis for the remission induction, maintenance, and relapse prevention is an attractive treatment approach with minimal adverse effects. However, the data is still conflicting. The purpose of this article is to provide the most comprehensive and ...
Source: Current Clinical Pharmacology - March 10, 2020 Category: Drugs & Pharmacology Authors: Naseer M, Poola S, Ali S, Samiullah S, Tahan V Tags: Curr Clin Pharmacol Source Type: research
Effects of Adjuvant Ketamine on Induction of Anesthesia for the Cesarean Section.
CONCLUSION: Overall use of ketamine is associated with better sedation and no significant side effects with low doses of ketamine, were seen in our study. Comparative studies using other analgesics, with larger sample size are therefore recommended.
PMID: 32156239 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 8, 2020 Category: Drugs & Pharmacology Authors: Moradkhani M, Beiranvand S, Nadri S, Hejri P Tags: Curr Clin Pharmacol Source Type: research
Long-acting injectable vs oral antipsychotics: Adherence, persistence and switching over three years of real-life analysis.
CONCLUSIONS: In all drugs of the present study, adherence values were better in LAI than in OA, whereas no statistically significant difference was found in persistence values.
PMID: 32148198 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 8, 2020 Category: Drugs & Pharmacology Authors: Romagnoli A, Santoleri F, Costantini A Tags: Curr Clin Pharmacol Source Type: research
Effects of Probiotics on Diabetic Nephropathy: A Systematic Review.
Abstract
Diabetic nephropathy is a frequent complication of diabetes mellitus as a result of functional and structural modifications in multiple kidney compartments. Probiotics have risen lately as the forthcoming therapeutic intervention but have not been systematically evaluated in diabetic nephropathy so far. The aim of this review is to systematically evaluate randomized controlled trials and experimental studies assessing the effect of probiotic supplements on diabetic nephropathy. An extensive literature search was conducted through electronic databases (Pubmed, Scopus, Cinahl and Medline) with the M...
Source: Current Clinical Pharmacology - March 1, 2020 Category: Drugs & Pharmacology Authors: Vlachou E, Ntikoudi A, Govina O, Lavdaniti M, Kotsalas N, Tsartsalis A, Dimitriadis G Tags: Curr Clin Pharmacol Source Type: research
Title: Is intraoperative opioids avoidance a utopia? A matched case-control study in laparoscopic hysterectomy.
CONCLUSIONS: Coming from an extensive daily practice, these data show that OFA is feasible and not associated with higher pain scores or longer PACU stay, suggesting the absence of specific immediate complications.
PMID: 32116198 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 1, 2020 Category: Drugs & Pharmacology Authors: Forget P, De Kock M, Lovqvist L, Lois F Tags: Curr Clin Pharmacol Source Type: research
Comparison of the effects of Dexamethasone and Ondansetron on the Reduction of Postoperative Nausea and Vomiting following Cesarean Section under Spinal Anesthesia.
CONCLUSION: Based on the results of this study, ondansetron had a significant effect on the alleviation of postoperative nausea and vomiting, as compared to dexamethasone in c-section surgical candidates.
PMID: 32116199 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 1, 2020 Category: Drugs & Pharmacology Authors: Karimi A, Nejadi J, Shamseh M, Ronasi N, Birjandi M Tags: Curr Clin Pharmacol Source Type: research
Therapeutic Effects of Prebiotics in Constipation: A Review.
Abstract
Constipation is a highly prevalent functional gastrointestinal disorder that may significantly affect the quality of life and health care costs. Treatment for constipation has been broadly reviewed by cognitive therapies, medications, and surgical interventions. Gut microbiota such as Bifidobacterium, Clostridium, Bacteroidetes, and Lactobacilli have been demonstrated in functional gastrointestinal disorders and prebiotics play a role in augmenting their presence. Prebiotics are ingredients in foods that remain undigested that may stimulate bacteria. There are variety of prebiotics however there o...
Source: Current Clinical Pharmacology - February 11, 2020 Category: Drugs & Pharmacology Authors: Naseer M, Poola S, Uraz S, Tahan V Tags: Curr Clin Pharmacol Source Type: research
Determination of fundamental medication reconciliation features with an international perspective.
CONCLUSION: According to the results, inclusion of factors like establishing phases for implementation, proper education, developing academic coordination, providing suitable facilities, specialization of the services, periodical evaluations and promoting pharmacy practice in development of medication reconciliation will potentially lead to an optimized plan.
PMID: 32039687 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 9, 2020 Category: Drugs & Pharmacology Authors: Tafazoli A Tags: Curr Clin Pharmacol Source Type: research
Angiotensin-Receptor Blockers (ARBs) and risk of Alzheimer ´s Disease: A meta-analysis.
CONCLUSION: ARB use may reduce the risk of incident AD. This association does not imply causation and further research is required to clarify potential mechanisms.
PMID: 32003701 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 30, 2020 Category: Drugs & Pharmacology Authors: Oscanoa TJ, Amado J, Vidal X, Romero-Ortuno R Tags: Curr Clin Pharmacol Source Type: research
An Assessment of Patients Factors Effect on Prescriber Adherence to Ischemic Stroke Secondary Prevention Guidelines.
CONCLUSION: Adherence to stroke secondary prevention guidelines was suboptimal especially in the antihypertensive prescription component. Further assessments and evaluations are required improve guidelines adherence.
PMID: 31971113 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 22, 2020 Category: Drugs & Pharmacology Authors: Al Qawasmeh M, Alhusban A, Alfwaress F, El-Salem K Tags: Curr Clin Pharmacol Source Type: research
Medication non-adherence in patients with osteoporosis: implications for clinical pharmacists and osteoporosis care providers.
CONCLUSION: Medication adherence for patients with osteoporosis has considered scope for improvement in Jordan. Simplifying dosage regimen in addition to taking patients' preferences when selecting the medications should be taken into account in future interventions designed to improve health outcomes for patients with osteoporosis.
PMID: 31951176 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 14, 2020 Category: Drugs & Pharmacology Authors: Jarab A, Mukattash T, Hilan H Tags: Curr Clin Pharmacol Source Type: research
Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers.
CONCLUSION: Single dose administration of pomegranate juice with cyclosporine did not significantly affect the oral bioavailability of cyclosporine. However, further work is needed to thoroughly evaluate the effect of pomegranate on narrow therapeutic drugs.
PMID: 31924158 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 9, 2020 Category: Drugs & Pharmacology Authors: Anlamlert W, Sermsappasuk P Tags: Curr Clin Pharmacol Source Type: research
