Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
CONCLUSIONS: This model for testing ventilatory response to hypercapnia discriminated the effect of 30 mg of oxycodone vs. placebo for up to 3 hours after a single dose. It may serve as a method to predict the relative effect of a drug on respiratory depression.PMID:33632110 | DOI:10.2174/1574884716666210225083213 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Authors: Lynn R Webster Erik Hansen Gregory J Stoddard Austin Rynders David Ostler Harley Lennon Source Type: research
Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
CONCLUSIONS: This model for testing ventilatory response to hypercapnia discriminated the effect of 30 mg of oxycodone vs. placebo for up to 3 hours after a single dose. It may serve as a method to predict the relative effect of a drug on respiratory depression.PMID:33632110 | DOI:10.2174/1574884716666210225083213 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Authors: Lynn R Webster Erik Hansen Gregory J Stoddard Austin Rynders David Ostler Harley Lennon Source Type: research
Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
CONCLUSIONS: This model for testing ventilatory response to hypercapnia discriminated the effect of 30 mg of oxycodone vs. placebo for up to 3 hours after a single dose. It may serve as a method to predict the relative effect of a drug on respiratory depression.PMID:33632110 | DOI:10.2174/1574884716666210225083213 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Authors: Lynn R Webster Erik Hansen Gregory J Stoddard Austin Rynders David Ostler Harley Lennon Source Type: research
Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
CONCLUSIONS: This model for testing ventilatory response to hypercapnia discriminated the effect of 30 mg of oxycodone vs. placebo for up to 3 hours after a single dose. It may serve as a method to predict the relative effect of a drug on respiratory depression.PMID:33632110 | DOI:10.2174/1574884716666210225083213 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Authors: Lynn R Webster Erik Hansen Gregory J Stoddard Austin Rynders David Ostler Harley Lennon Source Type: research
Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
CONCLUSIONS: This model for testing ventilatory response to hypercapnia discriminated the effect of 30 mg of oxycodone vs. placebo for up to 3 hours after a single dose. It may serve as a method to predict the relative effect of a drug on respiratory depression.PMID:33632110 | DOI:10.2174/1574884716666210225083213 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Authors: Lynn R Webster Erik Hansen Gregory J Stoddard Austin Rynders David Ostler Harley Lennon Source Type: research
Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
CONCLUSIONS: This model for testing ventilatory response to hypercapnia discriminated the effect of 30 mg of oxycodone vs. placebo for up to 3 hours after a single dose. It may serve as a method to predict the relative effect of a drug on respiratory depression.PMID:33632110 | DOI:10.2174/1574884716666210225083213 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2021 Category: Drugs & Pharmacology Authors: Lynn R Webster Erik Hansen Gregory J Stoddard Austin Rynders David Ostler Harley Lennon Source Type: research
Population Pharmacokinetics of Levetiracetam: a Systematic Review
CONCLUSION: Significant predictors for LEV pharmacokinetics are highlighted in this review. For future research, a population pharmacokinetic-pharmacodynamic model using a larger sample size should be conducted. From a clinical perspective, the published models should be externally evaluated before clinical implementation.PMID:33622228 | DOI:10.2174/1574884716666210223110658 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 24, 2021 Category: Drugs & Pharmacology Authors: Janthima Methaneethorn Nattawut Leelakanok Source Type: research
Population Pharmacokinetics of Levetiracetam: a Systematic Review
CONCLUSION: Significant predictors for LEV pharmacokinetics are highlighted in this review. For future research, a population pharmacokinetic-pharmacodynamic model using a larger sample size should be conducted. From a clinical perspective, the published models should be externally evaluated before clinical implementation.PMID:33622228 | DOI:10.2174/1574884716666210223110658 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 24, 2021 Category: Drugs & Pharmacology Authors: Janthima Methaneethorn Nattawut Leelakanok Source Type: research
STABIL-study: The Course of Therapy, Safety and Pharmacokinetic Parameters of Conversion of Prograf ® to Tacrolimus HEXAL®/Crilomus® in Renal Transplant Recipients - an Observational Study in Germany
CONCLUSION: In conclusion, conversion to the generic tacrolimus formulation can be considered safe and feasible in long-term kidney transplant recipients in Germany. As suggested by guidelines, a vigilant therapeutic drug monitoring is recommended to account for possible tacrolimus concentration variability on the individual patient level.PMID:33588739 | DOI:10.2174/1574884716666210215102756 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 16, 2021 Category: Drugs & Pharmacology Authors: Lukas J Lehner Klaus Kalb Karl Weigand Ulrich Pein Peter Schenker Wolfgang Seeger Robert Roehle Kerstin Dienes Fabian Halleck Klemens Budde Source Type: research
Drug-induced neuropsychiatric adverse events using post-marketing surveillance
CONCLUSION: Our results should raise physicians' awareness of drugs associated with abnormal behavior, but further investigation of these medications is warranted.PMID:33588740 | DOI:10.2174/1574884716666210215104540 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 16, 2021 Category: Drugs & Pharmacology Authors: Tomohito Wakabayashi Takahiro Nakatsuji Hiroko Kambara Iku Niinomi Saki Oyama Ayaka Inada Sayaka Ueno Mayako Uchida Kazunori Iwanaga Tatsuya Iida Keiko Hosohata Source Type: research
STABIL-study: The Course of Therapy, Safety and Pharmacokinetic Parameters of Conversion of Prograf ® to Tacrolimus HEXAL®/Crilomus® in Renal Transplant Recipients - an Observational Study in Germany
CONCLUSION: In conclusion, conversion to the generic tacrolimus formulation can be considered safe and feasible in long-term kidney transplant recipients in Germany. As suggested by guidelines, a vigilant therapeutic drug monitoring is recommended to account for possible tacrolimus concentration variability on the individual patient level.PMID:33588739 | DOI:10.2174/1574884716666210215102756 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 16, 2021 Category: Drugs & Pharmacology Authors: Lukas J Lehner Klaus Kalb Karl Weigand Ulrich Pein Peter Schenker Wolfgang Seeger Robert Roehle Kerstin Dienes Fabian Halleck Klemens Budde Source Type: research
Drug-induced neuropsychiatric adverse events using post-marketing surveillance
CONCLUSION: Our results should raise physicians' awareness of drugs associated with abnormal behavior, but further investigation of these medications is warranted.PMID:33588740 | DOI:10.2174/1574884716666210215104540 (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 16, 2021 Category: Drugs & Pharmacology Authors: Tomohito Wakabayashi Takahiro Nakatsuji Hiroko Kambara Iku Niinomi Saki Oyama Ayaka Inada Sayaka Ueno Mayako Uchida Kazunori Iwanaga Tatsuya Iida Keiko Hosohata Source Type: research
STABIL-study: The Course of Therapy, Safety and Pharmacokinetic Parameters of Conversion of Prograf ® to Tacrolimus HEXAL®/Crilomus® in Renal Transplant Recipients - an Observational Study in Germany.
CONCLUSION: In conclusion, conversion to the generic tacrolimus formulation can be considered safe and feasible in long-term kidney transplant recipients in Germany. As suggested by guidelines, a vigilant therapeutic drug monitoring is recommended to account for possible tacrolimus concentration variability on the individual patient level.
PMID: 33588739 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 14, 2021 Category: Drugs & Pharmacology Authors: Lehner LJ, Kalb K, Weigand K, Pein U, Schenker P, Seeger W, Roehle R, Dienes K, Halleck F, Budde K Tags: Curr Clin Pharmacol Source Type: research
Drug-induced neuropsychiatric adverse events using post-marketing surveillance.
CONCLUSION: Our results should raise physicians' awareness of drugs associated with abnormal behavior, but further investigation of these medications is warranted.
PMID: 33588740 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 14, 2021 Category: Drugs & Pharmacology Authors: Wakabayashi T, Nakatsuji T, Kambara H, Niinomi I, Oyama S, Inada A, Ueno S, Uchida M, Iwanaga K, Iida T, Hosohata K Tags: Curr Clin Pharmacol Source Type: research
Opioid dependency and myocardial infarction: A systematic review and meta-analysis.
CONCLUSION: Morphine dependency was significantly related to MI, but its risk factors were not significantly associated with morphine dependency. The increasing prevalence of opioid abuse in developing countries may be a reason for the growing incidence of MI in younger ages and individuals with no risk factors. Besides, physicians should consider the presence of impurities in morphine-based opioids and its possible effects on health.
PMID: 33511945 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 28, 2021 Category: Drugs & Pharmacology Authors: Rohani F, Rezayat AA, Zarifian A, Nour MG, Vakilian F, Sahebkar A, Dadgarmoghaddam M Tags: Curr Clin Pharmacol Source Type: research
