Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles.

CONCLUSION: The study revealed that oral administration of rHuKGF-loaded CNPs in methacrylic acid-methyl methacrylate copolymer-coated capsules is practically alternative to the IV administration since the absolute bioavailability of the orally administered rHuKGF-loaded CNPs, using rabbit as animal model, was 69%. Fluorescent microscope imaging revealed that rhodamine-labelled rHuKGF-loaded CNPs were taken up by FHs 74 Int cells, after 6 hours' incubation time, followed by increase in the proliferation rate.
PMID: 30457053 [PubMed - as supplied by publisher]

Source: Current Clinical Pharmacology - November 19, 2018 Category: Drugs & Pharmacology Authors: Kumar PV, Maki MAA, Wei YS, Tatt LM, Elumalai M, Cheah SC, Raghavan B, Majeed ABBA Tags: Curr Clin Pharmacol Source Type: research