Use of Synbiotics for Ulcerative Colitis Treatment.

CONCLUSION: The mechanism of actions in synbiotics supplementation is still unclear and needs more investigation although there are a wide number of data indicating that the synergism between probiotics and prebiotics is able to modulate the inflammatory response through cytokine expression and immune cell modulation induced by probiotic bacteria, that are also able to favour the production of SCFA by prebiotics digestion. SCFA are involved in mucosal barrier stabilization, regulatory T cell induction, promotion of anti-inflammatory cytokines secretion and inhibition of inflammatory factors such as TNF-α. Other: An urgent need is to create a panel of markers of inflammation, such as endoscopic or histologic scores and inflammatory markers that can give an accurate picture of UC progression/amelioration if used in a standard way in every study, as well as the use of an inflammatory bowel questionnaire to provide gastrointestinal symptom rating scale. PMID: 31878863 [PubMed - as supplied by publisher]
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research