Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats
The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potential of calvarial bone, was evaluated in Zucker diabetic fatty (ZDF) rats, an established rat model for obese T2DM. (Source: Bone)
Source: Bone - April 24, 2018 Category: Orthopaedics Authors: Guavri Caliaperoumal, Maite Souyet, Morad Bensidhoum, Herve Petite, Fani Anagnostou Tags: Full Length Article Source Type: research
Machine learning to predict the occurrence of bisphosphonate-related osteonecrosis of the jaw associated with dental extraction: A preliminary report
The aim of this study was to build and validate five types of machine learning models that can predict the occurrence of BRONJ associated with dental extraction in patients taking bisphosphonates for the management of osteoporosis. (Source: Bone)
Source: Bone - April 24, 2018 Category: Orthopaedics Authors: Dong Wook Kim, Hwiyoung Kim, Woong Nam, Hyung Jun Kim, In-Ho Cha Tags: Full Length Article Source Type: research
Type 2 diabetes impairs angiogenesis and osteogenesis in calvarial defects: MicroCT study in ZDF rats
The present study was motivated by the fact that bone regeneration in the compromised vascular microenvironment of T2DM is challenging and the factors that determine the adverse bone regeneration outcomes are poorly understood. For this purpose the effect of T2DM on osteogenic and angiogenic healing potential of calvarial bone, was evaluated in Zucker diabetic fatty (ZDF) rats, an established rat model for obese T2DM. (Source: Bone)
Source: Bone - April 24, 2018 Category: Orthopaedics Authors: Guavri Caliaperoumal, Maite Souyet, Morad Bensidhoum, Herve Petite, Fani Anagnostou Tags: Full Length Article Source Type: research
Machine learning to predict the occurrence of bisphosphonate-related osteonecrosis of the jaw associated with dental extraction: A preliminary report
The aim of this study was to build and validate five types of machine learning models that can predict the occurrence of BRONJ associated with dental extraction in patients taking bisphosphonates for the management of osteoporosis. (Source: Bone)
Source: Bone - April 24, 2018 Category: Orthopaedics Authors: Dong Wook Kim, Hwiyoung Kim, Woong Nam, Hyung Jun Kim, In-Ho Cha Tags: Full Length Article Source Type: research
GH prevents adipogenic differentiation of mesenchymal stromal stem cells derived from human trabecular bone via canonical Wnt signaling
The imbalance between osteogenesis and adipogenesis, which naturally accompanies bone marrow senescence, may contribute to the development of bone-associated diseases, like osteoporosis. In the present study, using primary human mesenchymal stromal cells (hMSCs) isolated from trabecular bone, we assessed the possible effect of GH on hMSC differentiation potential into adipocytes. GH (5 ng/ml) significantly inhibited the lipid accumulation in hMSCs cultured for 14 days in lipogenic medium. GH decreased the expression of the adipogenic genes, CCAAT/enhancer-binding protein alpha (C/EBPα) and adiponectin (ADN) as well a...
Source: Bone - April 22, 2018 Category: Orthopaedics Authors: Simona Bolamperti, Michela Signo, Alice Spinello, GianLuigi Moro, Gianfranco Fraschini, Francesca Guidobono, Alessandro Rubinacci, Isabella Villa Tags: Full Length Article Source Type: research
Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing
Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocaproic acid enhances appendicular bone healing and we sought to uncover the effect of aminocaproic acid on osteoprogenitor cells (OPCs) during bone regeneration. (Source: Bone)
Source: Bone - April 19, 2018 Category: Orthopaedics Authors: D. Bravo, A.M. Josephson, V. Bradaschia-Correa, M.Z. Wong, N.L. Yim, S.S. Neibart, S.N. Lee, J. Huo, T. Coughlin, M.M. Mizrahi, P. Leucht Tags: Full Length Article Source Type: research
Healing of fractures in osteoporotic bones in mice treated with bisphosphonates – A transcriptome analysis
Bisphosphonates (BP) are inhibitors of bone resorption and are used to treat postmenopausal osteoporosis. Long-term treatment with BP attenuates bone remodeling, possibly leading to detrimental consequences for the bones' ability to repair defects. To test this hypothesis, an animal model was established. Twelve week old mice were ovariectomized (OVX). Following confirmation of bone loss 8 weeks after OVX, the animals were treated with Alendronate (ALN) until sacrifice. After 5 weeks of ALN injections, the femoral bones were osteotomized and the osteotomies were either rigidly or non-rigidly stabilized. (Source: Bone)
Source: Bone - April 19, 2018 Category: Orthopaedics Authors: Michel Hauser, Mark Siegrist, Irene Keller, Willy Hofstetter Tags: Full Length Article Source Type: research
Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing
Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocaproic acid enhances appendicular bone healing and we sought to uncover the effect of aminocaproic acid on osteoprogenitor cells (OPCs) during bone regeneration. (Source: Bone)
Source: Bone - April 19, 2018 Category: Orthopaedics Authors: D. Bravo, A.M. Josephson, V. Bradaschia-Correa, M. Wong, N. Yim, S.S. Neibart, S.N. Lee, J. Huo, T. Coughlin, M. Mizrahi, P. Leucht Tags: Full Length Article Source Type: research
Healing of fractures in osteoporotic bones in mice treated with bisphosphonates – A transcriptome analysis
Bisphosphonates (BP) are inhibitors of bone resorption and are used to treat postmenopausal osteoporosis. Long-term treatment with BP attenuates bone remodeling, possibly leading to detrimental consequences for the bones' ability to repair defects. To test this hypothesis, an animal model was established. Twelve week old mice were ovariectomized (OVX). Following confirmation of bone loss 8 weeks after OVX, the animals were treated with Alendronate (ALN) until sacrifice. After 5 weeks of ALN injections, the femoral bones were osteotomized and the osteotomies were either rigidly or non-rigidly stabilized. (Source: Bone)
Source: Bone - April 19, 2018 Category: Orthopaedics Authors: Michel Hauser, Mark Siegrist, Irene Keller, Willy Hofstetter Tags: Full Length Article Source Type: research
Changes in pediatric DXA measures of musculoskeletal outcomes and correlation with quantitative CT following treatment of acute lymphoblastic leukemia
The objective of this study was to examine changes in DXA measures used in clinical practice and expressed as Z-scores using robust national reference data. Children and adolescents, ages 5 to 18 years were enrolled within 2 (median 0.8) years of completing ALL therapy. DXA total-body less-head bone mineral content (TBLH-BMC), and spine, total hip, femoral neck, and 1/3rd radius areal BMD (aBMD) were assessed in 45 participants at enrollment and 12-months later. (Source: Bone)
Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Sogol Mostoufi-Moab, Andrea Kelly, Jonathan A. Mitchell, Joshua Baker, Babette S. Zemel, Jill Brodsky, Jin Long, Mary B. Leonard Tags: Full Length Article Source Type: research
IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy
Bone loss associated with estrogen deficiency occurs due to a high level of bone remodelling, with a greater increase in the level of osteoclast-mediated bone resorption than osteoblast-mediated bone formation. Early studies showed that Interleukin-6 (IL-6) inhibition could prevent the increase in osteoclast numbers associated with ovariectomy. However, IL-6 signals through two possible pathways: classic IL-6 signalling (cis) utilizes a membrane-bound IL-6 receptor (IL-6R), while IL-6 trans-signalling occurs through a soluble IL-6R (sIL-6R). (Source: Bone)
Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Leah Lazzaro, Brett A. Tonkin, Ingrid J. Poulton, Narelle E. McGregor, Walter Ferlin, Natalie A. Sims Tags: Full Length Article Source Type: research
Inter-site variability of the osteocyte lacunar network in the cortical bone underpins fracture susceptibility of the superolateral femoral neck
The osteocytic lacunar network is considered to be an integral player in the regulation of bone homeostasis, and reduction in osteocytes is associated with reduced bone strength. Here, we analyzed site-specific patterns in osteocyte characteristics and matrix composition in the cortical compartment of the femoral neck to reveal structural basis of its fragility. (Source: Bone)
Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Tim Rolvien, Annika vom Scheidt, Kilian Stockhausen, Petar Milovanovic, Danijela Djonic, Jan Hubert, Thelonius Hawellek, Alexander Wacker, Volker Jebens, Klaus P üschel, Elizabeth A. Zimmermann, Marija Djuric, Michael Amling, Björn Busse Tags: Full Length Article Source Type: research
Changes in pediatric DXA measures of musculoskeletal outcomes and correlation with quantitative CT following treatment of acute lymphoblastic leukemia
The objective of this study was to examine changes in DXA measures used in clinical practice and expressed as Z-scores using robust national reference data. Children and adolescents, ages 5 to 18 years were enrolled within 2 (median 0.8) years of completing ALL therapy. DXA total-body less-head bone mineral content (TBLH-BMC), and spine, total hip, femoral neck, and 1/3rd radius areal BMD (aBMD) were assessed in 45 participants at enrollment and 12-months later. (Source: Bone)
Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Sogol Mostoufi-Moab, Andrea Kelly, Jonathan A. Mitchell, Joshua Baker, Babette S. Zemel, Jill Brodsky, Jin Long, Mary B. Leonard Tags: Full Length Article Source Type: research
IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy
Bone loss associated with estrogen deficiency occurs due to a high level of bone remodelling, with a greater increase in the level of osteoclast-mediated bone resorption than osteoblast-mediated bone formation. Early studies showed that Interleukin-6 (IL-6) inhibition could prevent the increase in osteoclast numbers associated with ovariectomy. However, IL-6 signals through two possible pathways: classic IL-6 signalling (cis) utilizes a membrane-bound IL-6 receptor (IL-6R), while IL-6 trans-signalling occurs through a soluble IL-6R (sIL-6R). (Source: Bone)
Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Leah Lazzaro, Brett A. Tonkin, Ingrid J. Poulton, Narelle E. McGregor, Walter Ferlin, Natalie A. Sims Tags: Full Length Article Source Type: research
