Inter-site variability of the osteocyte lacunar network in the cortical bone underpins fracture susceptibility of the superolateral femoral neck
The osteocytic lacunar network is considered to be an integral player in the regulation of bone homeostasis, and reduction in osteocytes is associated with reduced bone strength. Here, we analyzed site-specific patterns in osteocyte characteristics and matrix composition in the cortical compartment of the femoral neck to reveal structural basis of its fragility. (Source: Bone)
Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Tim Rolvien, Annika vom Scheidt, Kilian Stockhausen, Petar Milovanovic, Danijela Djonic, Jan Hubert, Thelonius Hawellek, Alexander Wacker, Volker Jebens, Klaus P üschel, Elizabeth A. Zimmermann, Marija Djuric, Michael Amling, Björn Busse Tags: Full Length Article Source Type: research
BBS9 gene in nonsyndromic craniosynostosis: Role of the primary cilium in the aberrant ossification of the suture osteogenic niche
Nonsyndromic craniosynostosis (NCS) is the premature ossification of skull sutures, without associated clinical features. Mutations in several genes account for a small number of NCS patients; thus, the molecular etiopathogenesis of NCS remains largely unclear.Our study aimed at characterizing the molecular signaling implicated in the aberrant ossification of sutures in NCS patients. Comparative gene expression profiling of NCS patient sutures identified a fused suture-specific signature, including 17 genes involved in primary cilium signaling and assembly. (Source: Bone)
Source: Bone - April 16, 2018 Category: Orthopaedics Authors: Marta Barba, Lorena Di Pietro, Luca Massimi, Maria Concetta Geloso, Paolo Frassanito, Massimo Caldarelli, Fabrizio Michetti, Stefano Della Longa, Paul A. Romitti, Concezio Di Rocco, Alessandro Arcovito, Ornella Parolini, Gianpiero Tamburrini, Camilla Bern Tags: Full Length Article Source Type: research
Bone health, activity and sedentariness at age 11 –12 years: Cross-sectional Australian population-derived study
To examine cross-sectional associations of children's bone health (size, density, strength) with moderate-vigorous physical activity (MVPA) and sedentary behaviour by considering: (1) duration of activity, (2) fragmentation, and (3) duration/fragmentation combined. (Source: Bone)
Source: Bone - April 16, 2018 Category: Orthopaedics Authors: William Osborn, Peter Simm, Tim Olds, Kate Lycett, Fiona K. Mensah, Josh Muller, Francois Fraysse, Najmi Ismail, Jennifer Vlok, David Burgner, John B. Carlin, Ben Edwards, Terence Dwyer, Peter Azzopardi, Sarath Ranganathan, Melissa Wake Tags: Full Length Article Source Type: research
BBS9 gene in nonsyndromic craniosynostosis: Role of the primary cilium in the aberrant ossification of the suture osteogenic niche
Nonsyndromic craniosynostosis (NCS) is the premature ossification of skull sutures, without associated clinical features. Mutations in several genes account for a small number of NCS patients; thus, the molecular etiopathogenesis of NCS remains largely unclear.Our study aimed at characterizing the molecular signaling implicated in the aberrant ossification of sutures in NCS patients. Comparative gene expression profiling of NCS patient sutures identified a fused suture-specific signature, including 17 genes involved in primary cilium signaling and assembly. (Source: Bone)
Source: Bone - April 16, 2018 Category: Orthopaedics Authors: Marta Barba, Lorena Di Pietro, Luca Massimi, Maria Concetta Geloso, Paolo Frassanito, Massimo Caldarelli, Fabrizio Michetti, Stefano Della Longa, Paul A. Romitti, Concezio Di Rocco, Alessandro Arcovito, Ornella Parolini, Gianpiero Tamburrini, Camilla Bern Tags: Full Length Article Source Type: research
Coffee and tea drinking in relation to risk of hip fracture in the Singapore Chinese Health Study
We examined the associations between consumption of coffee, tea and caffeine and risk of hip fracture in an Asian cohort. In a population-based prospective cohort of 63,257 Chinese men and women aged 45 –74 years in Singapore, a validated semi-quantitative food frequency questionnaire was used to assess habitual consumption of coffee and tea at baseline. (Source: Bone)
Source: Bone - April 14, 2018 Category: Orthopaedics Authors: Zhaoli Dai, Aizhen Jin, Avril Zixin Soh, Li-Wei Ang, Jian-Min Yuan, Woon-Puay Koh Tags: Full Length Article Source Type: research
Epiphyseal growth plate architecture is unaffected by early postnatal activation of the expression of R992C collagen II mutant
Spondyloepiphyseal dysplasia (SED) exemplifies a group of heritable diseases caused by mutations in collagenous proteins of the skeletal system. Its main feature is altered skeletal growth. Pathomechanisms of SED include: changes in the stability of collagen II molecules, inability to form proper collagen fibrils, excessive intracellular retention of mutant molecules, and endoplasmic reticulum stress. The complexity of this pathomechanism presents a challenge for designing therapies for SED. Our earlier research tested whether such therapies only succeed when applied during a limited window of development. (Source: Bone)
Source: Bone - April 13, 2018 Category: Orthopaedics Authors: Jolanta Fertala, Machiko Arita, Andrzej Steplewski, William V. Arnold, Andrzej Fertala Tags: Full Length Article Source Type: research
Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes
The objectives of this study were to assess whether different insulin regimens, metformin and rosiglitazone influence bone metabolism. We explored if the concentration of metformin and rosiglitazone in blood or improved glycaemic control altered bone turnover. (Source: Bone)
Source: Bone - April 11, 2018 Category: Orthopaedics Authors: Tore Bjerregaard Stage, Mette-Marie Hougaard Christensen, Niklas Rye J ørgensen, Henning Beck-Nielsen, Kim Brøsen, Jeppe Gram, Morten Frost Tags: Full Length Article Source Type: research
Sclerostin vaccination mitigates estrogen deficiency induction of bone mass loss and microstructure deterioration
In this study, we generated a SOST-Fc fusion protein which was composed of a SOST peptide Pro-Asn-Ala-Ile-Gly along with an IgG Fc fragment. SOST-Fc vaccination increased serum anti-SOST antibody levels and reduced serum SOST concentrations in mice. (Source: Bone)
Source: Bone - April 10, 2018 Category: Orthopaedics Authors: Feng-Sheng Wang, Re-Wen Wu, Wei-Shiung Lain, Tsai-Chen Tsai, Yu-Shan Chen, Yi-Chih Sun, Huei-Jing Ke, Jui-Chen Li, Jaulang Hwang, Jih-Yang Ko Tags: Full Length Article Source Type: research
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease
The aim of the study was to investigate the association between rs5859 in Sep15, rs1139793 in TrxR2 polymorphisms with the risks of KBD and to detect the expression of AP-1 pathway in KBD subjects and in vitro. 208 KBD and 206 control subjects were included. PCR-Restriction Fragment Length Polymorphism (RFLP), Amplification Refractory Mutation Specific-PCR (ARMS-PCR) and Western Blotting were conducted. The results showed the minor A-allele frequency of rs5859 in KBD was statistically significantly higher than that in the control group (P (Source: Bone)
Source: Bone - April 10, 2018 Category: Orthopaedics Authors: RuiPeng Wu, RongQiang Zhang, YongMin Xiong, WenYan Sun, YuanYuan Li, XiaoLi Yang, JiFeng Liu, Yong Jiang, Hao Guo, XiaoYan Mo, JunLing Cao Tags: Full Length Article Source Type: research
Transcriptional profiling of murine osteoblast differentiation based on RNA-seq expression analyses
Osteoblastic differentiation is a multistep process characterized by osteogenic induction of mesenchymal stem cells, which then differentiate into proliferative pre-osteoblasts that produce copious amounts of extracellular matrix, followed by stiffening of the extracellular matrix, and matrix mineralization by hydroxylapatite deposition. Although these processes have been well characterized biologically, a detailed transcriptional analysis of murine primary calvaria osteoblast differentiation based on RNA sequencing (RNA-seq) analyses has not previously been reported. (Source: Bone)
Source: Bone - April 10, 2018 Category: Orthopaedics Authors: Layal Abo Khayal, Johannes Gr ünhagen, Ivo Provazník, Stefan Mundlos, Uwe Kornak, Peter N. Robinson, Claus-Eric Ott Tags: Full Length Article Source Type: research
The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease
The aim of the study was to investigate the association between rs5859 in Sep15, rs1139793 in TrxR2 polymorphisms with the risks of KBD and to detect the expression of AP-1 pathway in KBD subjects and in vitro. 208 KBD and 206 control subjects were included. PCR-Restriction Fragment Length Polymorphism (RFLP), Amplification Refractory Mutation Specific-PCR (ARMS-PCR) and Western Blotting were conducted. The results showed the minor A-allele frequency of rs5859 in KBD was statistically significantly higher than that in the control group (P (Source: Bone)
Source: Bone - April 10, 2018 Category: Orthopaedics Authors: RuiPeng Wu, RongQiang Zhang, YongMin Xiong, WenYan Sun, YuanYuan Li, XiaoLi Yang, JiFeng Liu, Yong Jiang, Hao Guo, XiaoYan Mo, JunLing Cao Tags: Full Length Article Source Type: research
