Inverse association between sympathetic nervous system activity and bone mass in middle aged overweight individuals
This study examined whether sympathetic activation may impact bone health in overweight adults. (Source: Bone)
Source: Bone - March 29, 2018 Category: Orthopaedics Authors: Elisabeth Lambert, Sarah Phillips, Ainura Tursunalieva, Nina Eikelis, Carolina Sari, John Dixon, Nora Straznicky, Mariee Grima, Markus Schlaich, Gavin Lambert Tags: Full Length Article Source Type: research
Editorial Board
(Source: Bone)
Source: Bone - March 28, 2018 Category: Orthopaedics Source Type: research
Exercise prevents high fat diet-induced bone loss, marrow adiposity and dysbiosis in male mice
High fat diets can have detrimental effects on the skeleton as well as cause intestinal dysbiosis. Exercise prevents high fat (HF) diet-induced obesity and also improves bone density and prevents the intestinal dysbiosis that promotes energy storage. Previous studies indicate a link between intestinal microbial balance and bone health. Therefore, we examined whether exercise could prevent HF-induced bone pathology in male mice and determined whether benefits correlate to changes in host intestinal microbiota. (Source: Bone)
Source: Bone - March 28, 2018 Category: Orthopaedics Authors: Laura R. McCabe, Regina Irwin, Arjun Tekalur, Christian Evans, Jonathan D. Schepper, Narayanan Parameswaran, Mae Ciancio Tags: Full Length Article Source Type: research
Longitudinal changes in bone parameters in young girls with anorexia nervosa
Anorexia nervosa (AN) during childhood and adolescence has been reported to adversely affect bone health, but few studies have investigated longitudinal changes. (Source: Bone)
Source: Bone - March 27, 2018 Category: Orthopaedics Authors: Sheila Shepherd, Andreas Kyriakou, Mohamed Guftar Shaikh, Helen McDevitt, Charlotte Oakley, Michelle Thrower, S. Faisal Ahmed, Avril Mason Tags: Full Length Article Source Type: research
Low bone density and fractures before and after pediatric lung transplantation
Children undergoing lung transplant are at risk for low bone mineral density (BMD) and fractures. The effect of lung transplantation on bone health in pediatric patients is unknown. (Source: Bone)
Source: Bone - March 26, 2018 Category: Orthopaedics Authors: Melissa S. Putman, Tregony Simoneau, Henry A. Feldman, Alexandra Haagensen, Debra Boyer Tags: Full Length Article Source Type: research
Editorial Board
(Source: Bone)
Source: Bone - March 20, 2018 Category: Orthopaedics Source Type: research
Heterotopic Ossification: The Keys to the Kingdom
The metamorphosis of one mature tissue into another is one of the rarest and enigmatic events in medicine. When it involves the transformation of soft connective tissues into mature heterotopic bone, the process is called heterotopic ossification (HO). HO is exemplified by two ultra-rare genetic disorders that are progressive and disabling - fibrodysplasia ossificans progressiva (FOP) and progressive osseous heteroplasia (POH) - as well as a myriad of more common acquired and sporadic conditions. (Source: Bone)
Source: Bone - March 20, 2018 Category: Orthopaedics Authors: Frederick S. Kaplan, Robert J. Pignolo, Eileen M. Shore Tags: Editorial Source Type: research
The MEK5/ERK5 mitogen-activated protein kinase cascade is an effector pathway of bone-sustaining bisphosphonates that regulates osteogenic differentiation and mineralization
Bisphosphonates play an important role in the treatment of metabolic bone diseases such as osteoporosis. In addition to their anti-resorptive activity by triggering osteoclast apoptosis, nitrogen-containing bisphosphonates (N-BP) may also influence osteogenic differentiation, which might rely on their capacity to inhibit the mevalonate pathway. In vascular endothelial cells inhibition of this pathway by cholesterol-lowering statins activates the MEK5/ERK5 mitogen-activated protein kinase cascade, which plays an important role in cellular differentiation, apoptosis or inflammatory processes. (Source: Bone)
Source: Bone - March 19, 2018 Category: Orthopaedics Authors: Christian Adam, Lucia Gl ück, Regina Ebert, Matthias Goebeler, Franz Jakob, Marc Schmidt Tags: Full Length Article Source Type: research
Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis
Disuse osteoporosis (DOP) is a common complication of the lack of mechanical loading. The precise mechanism underlying DOP remains unknown, although epigenetic modifications may be a major cause. Recently, cumulative research has revealed that DNA methyltransferase (DNMT) proteins can catalyze the conversion of cytosine to 5-methylcytosine (5mC), altering the epigenetic state of DNA. Here, we report that DNMT1 expression and lncRNA-H19 methylation are upregulated in the femoral tissues of DOP rats, accompanied with inhibited Erk signaling pathway. (Source: Bone)
Source: Bone - March 16, 2018 Category: Orthopaedics Authors: Bing Li, Jie Zhao, Jian-xiong Ma, Guo-min Li, Yang Zhang, Guo-sheng Xing, Jun Liu, Xin-long Ma Tags: Full Length Article Source Type: research
Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis
This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs. (Source: Bone)
Source: Bone - March 16, 2018 Category: Orthopaedics Authors: Chih-Hsing Wu, Shih-Te Tu, Yin-Fan Chang, Ding-Cheng Chan, Jui-Teng Chien, Chih-Hsueh Lin, Sonal Singh, Manikanta Dasari, Jung-Fu Chen, Keh-Sung Tsai Tags: Full Length Article Source Type: research
Bone histomorphometry in transiliac biopsies from 48 normal, healthy men
The objective of this work is to present static and dynamic bone histomorphometry data from transilial bone biopsies performed on 48 healthy males, evenly distributed between ages 45 and 75. (Source: Bone)
Source: Bone - March 16, 2018 Category: Orthopaedics Authors: Robert R. Recker, Mohammed P. Akhter, Joan M. Lappe, Patrice Watson Tags: Full Length Article Source Type: research
