IL-6 trans-signalling mediates trabecular, but not cortical, bone loss after ovariectomy

Bone loss associated with estrogen deficiency occurs due to a high level of bone remodelling, with a greater increase in the level of osteoclast-mediated bone resorption than osteoblast-mediated bone formation. Early studies showed that Interleukin-6 (IL-6) inhibition could prevent the increase in osteoclast numbers associated with ovariectomy. However, IL-6 signals through two possible pathways: classic IL-6 signalling (cis) utilizes a membrane-bound IL-6 receptor (IL-6R), while IL-6 trans-signalling occurs through a soluble IL-6R (sIL-6R).

Source: Bone - April 18, 2018 Category: Orthopaedics Authors: Leah Lazzaro, Brett A. Tonkin, Ingrid J. Poulton, Narelle E. McGregor, Walter Ferlin, Natalie A. Sims Tags: Full Length Article Source Type: research