Healing of fractures in osteoporotic bones in mice treated with bisphosphonates – A transcriptome analysis

Bisphosphonates (BP) are inhibitors of bone resorption and are used to treat postmenopausal osteoporosis. Long-term treatment with BP attenuates bone remodeling, possibly leading to detrimental consequences for the bones' ability to repair defects. To test this hypothesis, an animal model was established. Twelve week old mice were ovariectomized (OVX). Following confirmation of bone loss 8  weeks after OVX, the animals were treated with Alendronate (ALN) until sacrifice. After 5 weeks of ALN injections, the femoral bones were osteotomized and the osteotomies were either rigidly or non-rigidly stabilized.

Source: Bone - April 19, 2018 Category: Orthopaedics Authors: Michel Hauser, Mark Siegrist, Irene Keller, Willy Hofstetter Tags: Full Length Article Source Type: research