Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing

Aminocaproic acid is approved as an anti-fibrinolytic for use in joint replacement and spinal fusion surgeries to limit perioperative blood loss. Previous animal studies have demonstrated a pro-osteogenic effect of aminocaproic acid in spine fusion models. Here, we tested if aminocaproic acid enhances appendicular bone healing and we sought to uncover the effect of aminocaproic acid on osteoprogenitor cells (OPCs) during bone regeneration.

Source: Bone - April 19, 2018 Category: Orthopaedics Authors: D. Bravo, A.M. Josephson, V. Bradaschia-Correa, M. Wong, N. Yim, S.S. Neibart, S.N. Lee, J. Huo, T. Coughlin, M. Mizrahi, P. Leucht Tags: Full Length Article Source Type: research