American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Worries About Getting Alzheimer's: Who's Concerned?
This study, based on data from the Health and Retirement Survey, examines correlates of worry. Results of multivariate analyses show the following to be independent and significant correlates: present memory ratings, perceived changes in memory, personal familiarity with AD, belief that being a first-degree relative of someone with AD heightens the chance of developing AD, and age. Interaction analyses show that memory ratings and perceived changes in memory functioning are associated with worry regardless of personal familiarity. These findings will enable practitioners to identify patients and clients at risk of being wo...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Cutler, S. J. Tags: Current Topics in Research Source Type: research

Characteristics and Mental Health of Hispanic Dementia Caregivers in New York City
Conclusions: Caregiver comorbidities and satisfaction with social support may be targets for intervention that could improve caregiver burden and depressive symptoms among Hispanic caregivers. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Luchsinger, J. A., Tipiani, D., Torres-Patino, G., Silver, S., Eimicke, J. P., Ramirez, M., Teresi, J., Mittelman, M. Tags: Current Topics in Research Source Type: research

The Family Series Workshop: A Community-Based Psychoeducational Intervention
This study describes an evaluation of a community-based psychoeducational intervention, called The Family Series Workshop, for caregivers of community-dwelling persons with Alzheimer’s disease or related dementias (ADRD). In a one-group pretest–posttest design, participants (n = 35) attended six weekly sessions. Caregiver stress, coping, and caregiving competence were evaluated along with demographic characteristics of participants. There was a significant improvement found for caregiving competence, and a marginally significant increase in coping with humor. Using regression analysis we also found that coping ...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Llanque, S. M., Enriquez, M., Cheng, A.-L., Doty, L., Brotto, M. A., Kelly, P. J., Niedens, M., Caserta, M. S., Savage, L. M. Tags: Current Topics in Research Source Type: research

Intracranial Hypotension-Like Syndrome After a Spinal Tap Test Performed for Idiopathic Normal Pressure Hydrocephalus
This report describes a woman with INPH who developed symptoms of IHS after a spinal tap test. There might be cases with IHS, like our case, who do not completely fulfill the current diagnostic criteria in terms of not having any objective evidence of intracranial hypotension but who also could not be explained by other conditions and recovered totally after classical IHS treatment. Current diagnostic criteria for IHS might be revised for those having normal neuroimaging and not accepting lumbar puncture. Nevertheless, when the history, signs, and symptoms strongly suggest IHS even with normal imaging, treatment should be ...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Kaya, D., Soysal, P., Isık, A. T. Tags: Current Topics in Care Source Type: research

Meaningful Activity for Persons With Dementia: Family Caregiver Perspectives
This study explores the concept of meaningful activity, as defined by caregivers of PWDs. Family caregivers of PWDs, who provide 3 hours of care over 3 days/week, were interviewed after 6 months of cholinesterase inhibitors (ChEIs) therapy. Caregiver responses (N = 906) to the open-ended question What do you believe getting involved in activities outside the home means for someone with dementia are assessed. The themes are analyzed in terms of content, frequency, co-occurrence, and dementia severity. Caregivers emphasize the benefits of social connectedness, physical health, and mental stimulation. Activity is also viewed ...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Roland, K. P., Chappell, N. L. Tags: Current Topics in Care Source Type: research

Cognitive Screening in Persons With Chronic Diseases in Primary Care: Challenges and Recommendations for Practice
An integrative literature review was performed to identify the challenges in current cognitive screening. The aim of the review was to serve as an evaluative resource to guide clinicians in the selection of the best available cognitive screening measures for early assessment of mild cognitive impairment (MCI) in people with chronic diseases. The review classified the available cognitive screening measures according to purpose, time to administer, and cognitive domains assessed as: 1) simple/ brief cognitive screening measures, 2) disease specific screening measures, 3) domain specific screening measures, 4) self-administer...
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Athilingam, P., Visovsky, C., Elliott, A. F., Rogal, P. J. Tags: Reviews Source Type: research

Lack of Genetic Association Between TREM2 and Alzheimer's Disease in East Asian Population: A Systematic Review and Meta-Analysis
Conclusion: In our study, we found that TREM2 variant is likely not associated with AD in East Asian population. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - August 10, 2015 Category: Geriatrics Authors: Huang, M., Wang, D., Xu, Z., Xu, Y., Xu, X., Ma, Y., Xia, Z. Tags: Reviews Source Type: research

The Effectiveness of Reality Orientation in the Treatment of Alzheimer's Disease
Alzheimer’s disease (AD) is the most frequent cause of dementia. This work aims to assess the effectiveness of reality orientation (RO), a traditional, extensively documented cognitive enhancement technique, when combined with acetylcholinesterase inhibitors in the treatment of AD. Fourteen patients with AD having mild to moderate dementia receiving standard treatment with donepezil were randomly assigned to control and treatment groups. Patients in the treatment group were submitted to weekly RO sessions for 6 months. Cognitive outcomes were assessed based on scores in the Consortium to Establish a Registry for Alzh...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Camargo, C. H. F., Justus, F. F., Retzlaff, G. Tags: Current Topics in Research Source Type: research

Validation of AD-CSF-Index in Chinese Patients With Alzheimer's Disease and Nondemented Controls
The objective of this study was to validate the diagnostic accuracy of AD-CSF-Index in our local Chinese patients with AD compared to nondemented controls. A total of 36 patients, which included 24 patients with AD and 12 nondemented controls, were recruited. Chinese patients with AD showed higher mean AD-CSF-Indices than nondemented controls (AD = 1.25-1.3, normal = 0.62-0.63; P < .001). The AD-CSF-indices have a high sensitivity and specificity of 86.4% to 90.9% and 83.3%, respectively, in differentiating patients with AD from nondemented controls. After selecting the patients with "pure AD" and "pure normal" controls...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Chu, L.-W., Shea, Y. F., Ha, J. Tags: Current Topics in Research Source Type: research

Serum sEPCR Levels Are Elevated in Patients With Alzheimer's Disease
In this study, we found that serum sEPCR levels were significantly increased in patients with AD when compared to control participants (P = .0005). There was no significant difference between patients with mild cognitive impairment (MCI) and healthy controls (P = .055) or between patients with AD and MCI (P = .054). Importantly, our results also indicate that the degree of cognitive impairment is significantly correlated with serum sEPCR levels in all patients and healthy controls. These findings suggest that serum sEPCR levels could be a potential candidate for a biomarker panel for AD diagnosis. (Source: American Journal...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Zhu, Y., Chen, Z., Chen, X., Hu, S. Tags: Current Topics in Research Source Type: research

Caregiving Experiences of Family Members of Persons With Dementia in South India
This study reports on the first phase of an investigation aimed at adapting The Savvy Caregiver program, a successful family caregiving curriculum developed in the United States, for application in South India. Thirty family members caring for a person with dementia were interviewed regarding their experiences as caregivers (CGs). Qualitative interviews were conducted with the family member at a geriatric clinic, while other diagnostic procedures were being carried out with the person with dementia. Findings from the study revealed that although family members understood the term CG, none could identify a word for CG in hi...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Narayan, S. M., Varghese, M., Hepburn, K., Lewis, M., Paul, I., Bhimani, R. Tags: Current Topics in Research Source Type: research

ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China
In this study, we investigated the relationship between ApoE4 and the cognitive function of the old people. A total of 156 old people were investigated, of whom 31 were ApoE4 carriers. The ApoE4 primarily influenced the global cognitive function, perceptual speed, and work memory. The results indicate that ApoE4 has significant negative effect on the cognitive function of the elderly people who are 60 years and older. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Sun, S., Fu, J., Chen, J., Pang, W., Hu, R., Li, H., Tan, L., Jiang, Y. Tags: Current Topics in Research Source Type: research

Pathomechanisms of Atrophy in Insular Cortex in Alzheimer's Disease
The insular cortex is associated with neuropsychiatric symptoms, changes in cardiovascular and autonomic control, and mortality in Alzheimer’s dementia. However, the insular cortex does not provide information on the contribution of the other cortices to cognitive decline. We hypothesized that the factors that affect to atrophy in insular cortex are different from other cortical regions. A total of 42 patients with probable Alzheimer’s dementia were included in the analyses. The manual drawing of regions of interest was used to detect insular cortex located in the deep gray matter and to avoid coatrophy. Covari...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Moon, Y., Moon, W.-J., Han, S.-H. Tags: Current Topics in Research Source Type: research

Caregiving for a Loved One With Dementia at the End of Life: An Emergent Theory of Rediscovering
This study provides a substantive theory that may serve as a framework for future studies. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Lewis, L. F. Tags: Current Topics in Research Source Type: research

The Hypothalamus in Alzheimer's Disease: A Golgi and Electron Microscope Study
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by irreversible decline of mental faculties, emotional and behavioral changes, loss of motor skills, and dysfunction of autonomic nervous system and disruption of circadian rhythms (CRs). We attempted to describe the morphological findings of the hypothalamus in early cases of AD, focusing our study mostly on the suprachiasmatic nucleus (SCN), the supraoptic nucleus (SON), and the paraventricular nucleus (PVN). Samples were processed for electron microscopy and silver impregnation techniques. The hypothalamic nuclei demonstrated a sub...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 22, 2015 Category: Geriatrics Authors: Baloyannis, S. J., Mavroudis, I., Mitilineos, D., Baloyannis, I. S., Costa, V. G. Tags: Current Topics in Research Source Type: research