American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition
Loss of synaptic function is critical in the pathogenesis of Alzheimer’s disease (AD) and other central nervous system (CNS) degenerations. A promising candidate in the regulation of synaptic function is Shank, a protein that serves as a scaffold for excitatory synaptic receptors and proteins. Loss of Shank alters structure and function of the postsynaptic density (PSD). Shank proteins are associated with N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor loss at the PSD in AD; mutations in Shank also lead to autism spectrum disorders (ASDs) and schizophrenia, both of which a...
Source: American Journal of Alzheimer's Disease and Other Dementias - June 18, 2014 Category: Geriatrics Authors: Chow, F., Gong, Y., Lippa, C. F. Tags: Reviews Source Type: research

Mild Cognitive Impairment: A Brief Review and Suggested Clinical Algorithm
Mild cognitive impairment (MCI) is a dynamic state between normal cognition and dementia, where interventions can be taken to stop or delay the progression to dementia. It is broadly of 2 types—amnestic, where memory loss is the chief concern and nonamnestic, where it is not. One variant of nonamnestic, dysexecutive, being more prevalent is sometimes known as a separate subtype by itself. Diagnosis of MCI is mostly clinical and is aided by various scales and neuropsychological testing. Functional imaging studies help in early detection and is superior to biomarkers or structural magnetic resonance imaging. Although t...
Source: American Journal of Alzheimer's Disease and Other Dementias - June 18, 2014 Category: Geriatrics Authors: Ghosh, S., Libon, D., Lippa, C. Tags: Reviews Source Type: research

Adaptation to Early-Stage Nonfluent/Agrammatic Variant Primary Progressive Aphasia: A First-Person Account
This report describes a range of strategies and adaptations designed to improve the quality of life of a person with early-stage PPA-G, based on my experience under the care of a multidisciplinary medical team. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - June 18, 2014 Category: Geriatrics Authors: Douglas, J. T. Tags: Thoughts, Opinions, and Controversies Source Type: research

An Intergenerational Choir Formed to Lessen Alzheimer's Disease Stigma in College Students and Decrease the Social Isolation of People With Alzheimer's Disease and Their Family Members: A Pilot Study
The intergenerational choir was formed for the purpose of combating the stigma of Alzheimer's disease in college students, and in that process also lessening the social isolation of people with AD and their family members. The choir was composed of 13 college students and 13 people with AD and a family member. Data from the college students were gathered through semi-structured open-ended questions on attitudes and knowledge about AD, collected at three points in time over 8 weeks of rehearsals. Data were collected from the people with AD and their family members through a focus group and observations over 8 weeks of rehea...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Harris, P. B., Caporella, C. A. Tags: Current Topics in Research Source Type: research

Pattern of and Risk Factors for Brain Microbleeds in Neurodegenerative Dementia
Conclusions: Brain microbleeds are associated with vascular burden and AD diagnosis in old patients with neurodegenerative dementia. More research is warranted regarding the mechanisms and potential clinical implications of these results. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Olazaran, J., Ramos, A., Boyano, I., Alfayate, E., Valenti, M., Rabano, A., Alvarez-Linera, J. Tags: Current Topics in Research Source Type: research

Cognitive Dysfunction and Age-Related Macular Degeneration
In this study, data showed that patients affected by late-stage AMD have a worse global cognitive function than those of the controls and, in particular, show worse performances in memory tasks. Moreover, patients affected by the dry form of AMD are significantly impaired in executive functions in addition to memory. Data support the hypothesis of a possible association between AMD and cognitive impairment. In particular, patients affected by the dry form of AMD may be at greater risk of developing subsequent dementia. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Rozzini, L., Riva, M., Ghilardi, N., Facchinetti, P., Forbice, E., Semeraro, F., Padovani, A. Tags: Current Topics in Research Source Type: research

Open-Label, Short-Term, Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease With Functional Imaging Correlates and Literature Review
Conclusions: There was improvement in aspects of language after four rTMS treatments, sustained a month after treatment cessation. Our results are consistent with other studies and standardization of treatment protocols using functional imaging may be of benefit. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Devi, G., Voss, H. U., Levine, D., Abrassart, D., Heier, L., Halper, J., Martin, L., Lowe, S. Tags: Current Topics in Research Source Type: research

Vascular Risk Factors and Mild Cognitive Impairment in the Elderly Population in Southwest China
Conclusions: Hypertension, CHD, TC, and LDL-C are independent risk factors for MCI. Moreover, patients with vascular diseases have a higher risk of MCI; however, the amount of vascular diseases does not increase the risk of MCI. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Zou, Y., Zhu, Q., Deng, Y., Duan, J., Pan, L., Tu, Q., Dai, R., Zhang, X., Chu, L.-W., Lu, Y. Tags: Current Topics in Research Source Type: research

Apolipoprotein E Alleles in Cuban Patients With Mild Cognitive Impairment
Conclusions: The patients exhibited amnestic MCI multiple domains. Cognitive performance was worse in patients who carried the ApoE 4 allele. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Suarez, V. M., Fernandez, Y., Lopez, E. d. C. R., Clarke, D. H., Bobes, M. A., Riveron, A. M., Lopez-Canovas, L. Tags: Current Topics in Research Source Type: research

Interactive Effects of Apolipoprotein E4 and Diabetes Risk on Later Myelinating White Matter Regions in Neurologically Healthy Older Aged Adults
Possession of the apolipoprotein E4 (APOE4) allele and diabetes risk are independently related to reduced white matter (WM) integrity that may contribute to the development of Alzheimer’s disease (AD). The purpose of this study is to examine the interactive effects of APOE4 and diabetes risk on later myelinating WM regions among healthy elderly individuals at risk of AD. A sample of 107 healthy elderly (80 APOE4–/27 APOE4+) individuals underwent structural magnetic resonance imaging/diffusion tensor imaging (DTI). Data were prepared using Tract-Based Spatial Statistics, and a priori regions of interest (ROIs) w...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Foley, J. M., Salat, D. H., Stricker, N. H., Zink, T. A., Grande, L. J., McGlinchey, R. E., Milberg, W. P., Leritz, E. C. Tags: Current Topics in Research Source Type: research

Observation of Social Behavior in Frontotemporal Dementia
Conclusions: The systematic observation of social behavior during routine activities may be one of the best ways to distinguish patients with bvFTD from normal individuals and from patients with other dementias. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Mendez, M. F., Fong, S. S., Shapira, J. S., Jimenez, E. E., Kaiser, N. C., Kremen, S. A., Tsai, P.-H. Tags: Current Topics in Management Source Type: research

Possible Link Between Toxoplasma Gondii and the Anosmia Associated With Neurodegenerative Diseases
Toxoplasma gondii is an intracellular protozoan infecting 30% to 50% of global human population. Recently, it was suggested that chronic latent neuroinflammation caused by the parasite may be responsible for the development of several neurodegenerative diseases manifesting with the loss of smell. Studies in animals inoculated with the parasite revealed cysts in various regions of the brain, including olfactory bulb. Development of behavioral changes was paralleled by the preferential persistence of cysts in defined anatomic structures of the brain, depending on the host, strain of the parasite, its virulence, and route of ...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Prandota, J. Tags: Review Source Type: research

Neuropsychological Factors Related to College Ice Hockey Concussions
We analyzed data from 74 male collegiate hockey players. Each athlete’s season began with a baseline administration of the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) neuropsychology test battery. Fourteen athletes sustained a sport-related head injury and were readministered the test to assess the impact of the injury. A significant decrease in performance (compared to baseline) on immediate and delayed word recall and designs followed the first concussion. Following a second sport-related concussion, the 4 affected athletes showed significant decrease in visual motor speed. Performance impro...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Pedersen, H. A., Ferraro, F. R., Himle, M., Schultz, C., Poolman, M. Tags: Thoughts, Opinions, and Controversies Source Type: research

Mrs Auguste D{eter} demise in 1906 was in Aminoff Suffering Syndrome
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Aminoff, B. Z. Tags: Thoughts, Opinions, and Controversies Source Type: research

Head Injury and Neuropsychological Issues
(Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 11, 2014 Category: Geriatrics Authors: Lippa, C. F. Tags: Review of Issue Source Type: research