American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Burden Among Male Alzheimer's Caregivers: Effects of Distinct Coping Strategies
Focusing on the understudied, increasing population of male Alzheimer’s disease (AD) caregivers, the purpose of this study was to identify their likelihood of utilizing 3 coping strategies (task focused, emotion focused, and avoidance focused) and to examine the effects of each coping strategy on caregiving burden. Data were collected from 138 male AD caregivers in southern United States, including geographically proportional representation of African Americans in the sample. Stepwise regression revealed effects of each coping strategy on caregiving burden, controlling for demographics. The sample reported high burde...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 12, 2015 Category: Geriatrics Authors: Geiger, J. R., Wilks, S. E., Lovelace, L. L., Chen, Z., Spivey, C. A. Tags: Current Topics in Care Source Type: research

Experiences of Nursing Staff Using Dementia-Specific Case Conferences in Nursing Homes
Conclusions: CC-IdA represents an important tool in the management of challenging behavior of people with dementia. For the successful implementation of these case conferences, both structural and personal resources are needed. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - May 12, 2015 Category: Geriatrics Authors: Holle, D., Kruger, C., Halek, M., Sirsch, E., Bartholomeyczik, S. Tags: Current Topics in Care Source Type: research

Is Alzheimer's Disease Autoimmune Inflammation of the Brain That Can be Treated With Nasal Nonsteroidal Anti-Inflammatory Drugs?
The Alzheimer’s Association recently reported that a woman’s estimated lifetime risk of developing Alzheimer’s at age 65 is 1 in 6, compared to nearly 1 in 11 for a man (ie, female to male ratio 1.8). Based on female to male ratio, Alzheimer’s disease could well be an autoimmune disorder. Like Alzheimer’s, multiple sclerosis, an autoimmune inflammation of the central nervous system, has a female to male ratio of 2.3. Also based on female to male ratio, Alzheimer’s resembles the autoimmune inflammatory disease rheumatoid arthritis, which has a female to male ratio of 2.7. The reasons for ...
Source: American Journal of Alzheimer's Disease and Other Dementias - May 12, 2015 Category: Geriatrics Authors: Lehrer, S., Rheinstein, P. H. Tags: Opinions and Controversies Source Type: research

Field Observations into the Environmental Soul: Spatial Configuration and Social Life for People Experiencing Dementia
This article focuses on the important, facilitating role architectural design plays in social interaction within long-term care facilities (LTCFs) serving people with dementia. Here, we apply space syntax, a set of theories and techniques for the analysis of spatial configurations, as an objective measure of environmental characteristics. Almost 150 rounds of behavioral observations were collected in the social spaces of 3 LTCFs. Using the visibility and proximity metrics of space syntax, the locations of occurrence of various social activities in relation to the furniture and spatial layout on architectural floor plans ha...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Ferdous, F., Moore, K. D. Tags: Current Topics in Research Source Type: research

Insulin Treatment Prevents the Increase in D-Serine in Hippocampal CA1 Area of Diabetic Rats
Conclusions: These results suggest that insulin treatment has a potent protection effect on CA1-LTP, spatial learning and memory ability of the diabetic rats in vivo. Furthermore, insulin may take effect by inhibiting the overactivation of N-methyl-d-aspartate receptors, which play a critical role in neurotoxicity. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Yang, J., Song, Y., Wang, H., Liu, C., Li, Z., Liu, Y., Kong, Y. Tags: Current Topics in Research Source Type: research

Prolonged grief in caregivers of community-dwelling dementia patients
Conclusions: Caregivers of patients with dementia may experience grief symptoms that are associated with low educational level, high level of burden and anxiety, and high perceived deterioration of their demented relatives’ cognitive and functional abilities. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Passoni, S., Toraldo, A., Villa, B., Bottini, G. Tags: Current Topics in Research Source Type: research

Sulforaphane Ameliorates Neurobehavioral Deficits and Protects the Brain From Amyloid {beta} Deposits and Peroxidation in Mice With Alzheimer-Like Lesions
In conclusion, SFN ameliorates neurobehavioral deficits and protects the brain from Aβ deposits and peroxidation in mice with Alzheimer-like lesions, suggesting SFN is likely a potential phytochemical to be used in AD therapeutics. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Zhang, R., Miao, Q.-W., Zhu, C.-X., Zhao, Y., Liu, L., Yang, J., An, L. Tags: Current Topics in Research Source Type: research

Role of Traditional Nonsteroidal Anti-inflammatory Drugs in Alzheimer's Disease: A Meta-analysis of Randomized Clinical Trials
The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in prevention of Alzheimer’s disease (AD) has been evaluated in many studies. We performed a meta-analysis to summarize the existing evidence on the relation between use of classical NSAIDs and AD. Randomized controlled trials (RCTs) evaluating the role of classical NSAIDs in AD was searched using different search engines. The RCTs in patients who had the degree of AD measured on Mini-Mental State Examination (MMSE) or AD Assessment Scale-Cognitive subscale (ADAS-cog) were included in the study. The RCTs and data (AD scores) were independently assessed by 2 re...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Gupta, P. P., Pandey, R. D., Jha, D., Shrivastav, V., Kumar, S. Tags: Current Topics in Research Source Type: research

Clinical Characterization of Mild Cognitive Impairment as a Prodrome to Dementia With Lewy Bodies
Limited information regarding the specificity of mild cognitive impairment (MCI) as it relates to dementia with Lewy bodies (DLB) exists. Here, we summarize the clinical phenotype of MCI in clinically suspect DLB. Ten patients with a primary diagnosis of MCI and secondary diagnoses of DLB were identified. Patients underwent clinical neurological and neuropsychological evaluation that included application of McKeith criteria. We found parkinsonism and gait abnormality in 9 of the 10 patients; fluctuations in 8 of the 10; and hallucinations and dream enactment behavior in 5 of the 10. Of the 10 cases, 4 were classified as no...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Belden, C. M., Kahlon, V., Malek-Ahmadi, M., Tsai, A., Sabbagh, M. N. Tags: Current Topics in Research Source Type: research

Feeding Tubes for Older People With Advanced Dementia Living in the Community in Israel
Conclusion: Feeding tube use in OPAD in the community is associated with negative outcomes and increased caregiver burden. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Bentur, N., Sternberg, S., Shuldiner, J., Dwolatzky, T. Tags: Current Topics in Research Source Type: research

Cognitive Stimulation of Executive Functions in Mild Cognitive Impairment: Specific Efficacy and Impact in Memory
We present the results of a program which aims to teach specific strategies and metacognitive abilities in order for patients to be able to carry out attentional and executive tasks. Two groups (A and B) were compared in a cross-over design. After the first evaluation, Group A (but not B) participated in a six month cognitive stimulation program. After a second assessment, only Group B received treatment and then a final evaluation was carried out on both groups. The results show that: i) both groups improved their performance as an effect of training; ii) improvements generalized to memory and general cognitive tasks; iii...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Moro, V., Condoleo, M. T., Valbusa, V., Broggio, E., Moretto, G., Gambina, G. Tags: Current Topics in Research Source Type: research

Standardized Mini-Mental State Examination Scores and Verbal Memory Performance at a Memory Center: Implications for Cognitive Screening
Memory decline is often among the first signs heralding the emergence of mild cognitive impairment or dementia regardless of etiology. Despite its limited inclusion of memory screening, the Mini-Mental State Exam (MMSE) continues to be the most ubiquitous, first-line screening tool for dementia and cognitive decline. In response to well documented problems with the sensitivity of this instrument and the growing importance of cognitive screening, we assessed the utility of the MMSE as a screening tool among older adults presenting for evaluation at a memory clinic. The Standardized MMSE and a standardized verbal memory test...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Lacy, M., Kaemmerer, T., Czipri, S. Tags: Current Topics in Research Source Type: research

Effect of APOE and CHRNA7 Genotypes on the Cognitive Response to Cholinesterase Inhibitor Treatment at Different Stages of Alzheimer's Disease
The loss of cholinergic transmission is considered to be an important cause of Alzheimer’s disease (AD). Treatment with acetyl cholinesterase inhibitors (ChEIs) shows benefits; however, great heterogeneity has been observed in patient responses. We evaluated apolipoprotein E (APOE) and α7 nicotinic receptor (CHRNA7) single-nucleotide polymorphisms (SNPs) and associated these SNPs with pharmacological responses to ChEIs in a Brazilian population with AD. We studied 177 outpatients using ChEIs, and they were classified as responders and nonresponders according to variation in Mini-Mental State Examination (MMSE) ...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Braga, I. L. S., Silva, P. N., Furuya, T. K., Santos, L. C., Pires, B. C., Mazzotti, D. R., Bertolucci, P. H., Cendoroglo, M. S., Smith, M. C. Tags: Current Topics in Research Source Type: research

Supporting Direct Care Workers in Dementia Care: Effects of a Psychoeducational Intervention
An experimental study using a pre–posttest control group design was conducted to assess the effects of a person-centered care-based psychoeducational intervention on direct care workers’ stress, burnout, and job satisfaction. The intervention aimed to develop person-centered care competences and tools for stress management. Four aged care facilities were randomly assigned to a psychoeducational or an education-only intervention (control). Data were collected from 56 direct care workers (female, mean age 44.72 ± 9.02) through measurements of burnout (Maslach Burnout Inventory), job satisfaction (Minnesota...
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Barbosa, A., Nolan, M., Sousa, L., Figueiredo, D. Tags: Current Topics in Care Source Type: research

Melatonin and Melatonin Agonist for Delirium in the Elderly Patients
In this study, ramelteon was found to be beneficial in preventing delirium in medically ill individuals when compared to placebo. Ramelteon was well tolerated in this study. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - March 23, 2015 Category: Geriatrics Authors: Chakraborti, D., Tampi, D. J., Tampi, R. R. Tags: Review Source Type: research