American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Odor Identification in Frontotemporal Lobar Degeneration Subtypes
Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear ...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Magerova, H., Vyhnalek, M., Laczo, J., Andel, R., Rektorova, I., Kadlecova, A., Bojar, M., Hort, J. Tags: Current Topics in Research Source Type: research

Utility of the Cognitive Difficulties Scale and Association With Objective Test Performance
Subjective memory complaints (SMCs) are commonly noted in memory disorder clinic patients. The present study sought to examine the presence of SMCs on the Cognitive Difficulties Scale (CDS) in older adults and to examine the relationship between CDS scores and current cognitive ability. Participants were 50 adults diagnosed with possible/probable Alzheimer’s disease (AD), 100 with amnestic mild cognitive impairment (MCI) and 84 cognitively healthy controls (HCs). Participants completed a neuropsychological evaluation and the self- and informant-reported CDS. Results indicated that greater self-reported SMCs were note...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Buelow, M. T., Tremont, G., Frakey, L. L., Grace, J., Ott, B. R. Tags: Current Topics in Research Source Type: research

A Selective Egocentric Topographical Working Memory Deficit in the Early Stages of Alzheimer's Disease: A Preliminary Study
The aim of this study was to determine whether an egocentric topographical working memory (WM) deficit is present in the early stages of Alzheimer's disease (AD) with respect to other forms of visuospatial WM. Further, we would investigate whether this deficit could be present in patients having AD without topographical disorientation (TD) signs in everyday life assessed through an informal interview to caregivers. Seven patients with AD and 20 healthy participants performed the Walking Corsi Test and the Corsi Block-Tapping Test. The former test requires memorizing a sequence of places by following a path and the latter i...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Bianchini, F., Di Vita, A., Palermo, L., Piccardi, L., Blundo, C., Guariglia, C. Tags: Current Topics in Research Source Type: research

Acupuncture Stimulation of Taichong (Liv3) and Hegu (LI4) Modulates the Default Mode Network Activity in Alzheimer's Disease
Conclusion: It was found that the acupuncture stimulation could modulate the DMN activity in AD. The current findings suggest that the acupuncture treatment on the relative earlier AD patients might have a better therapy effect. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Liang, P., Wang, Z., Qian, T., Li, K. Tags: Current Topics in Research Source Type: research

Which Rivastigmine Formula is Better for Heart in Elderly Patients With Alzheimer's Disease: Oral or Patch?
Conclusion: It was demonstrated that rivastigmine formulations were not associated with increased arrhythmogenic or hypotensive effects in elderly patients with AD and was not superior to each other. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Isik, A. T., Soysal, P., Yay, A. Tags: Current Topics in Research Source Type: research

Clinical Presentation of Early-Onset Alzheimer's Disease as a Result of Mutation in Exon 12 of the PSEN-1 Gene
Conclusion: Our case describes a new phenotype of a known mutation of PSEN-1 at codon 424. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Klimkowicz-Mrowiec, A., Bodzioch, M., Szczudlik, A., Slowik, A. Tags: Current Topics in Research Source Type: research

Differential Diagnosis of Degenerative Dementias Using Basic Neuropsychological Tests: Multivariable Logistic Regression Analysis of 301 Patients
Conclusion: The models constructed from basic neuropsychological variables allowed an accurate differential diagnosis of AD versus DLB but not of FTLD versus AD or DLB. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Jimenez-Huete, A., Riva, E., Toledano, R., Campo, P., Esteban, J., Barrio, A. D., Franch, O. Tags: Current Topics in Research Source Type: research

Correlational Analysis of 5 Commonly Used Measures of Cognitive Functioning and Mental Status: An Update
There are numerous measures for detecting the presence of dementia and quantifying its severity and progression. We analyzed the relations between scores on 5 commonly used measures (Mini-Mental State Examination, Montreal Cognitive Assessment, Alzheimer’s Disease Assessment Scale-Cognitive Subscale, Activities of Daily Living Scale, and Global Deterioration Scale) of 101 successive admissions to a memory clinic. Patients were included in the analysis only if they received a diagnosis of mild cognitive impairment (MCI) due to Alzheimer’s disease (AD) pathophysiological process or probable AD and if they receive...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Solomon, T. M., deBros, G. B., Budson, A. E., Mirkovic, N., Murphy, C. A., Solomon, P. R. Tags: Current Topics in Research Source Type: research

Cognitive Impairment Among Elderly Individuals in Shanghai Suburb, China: Association of C-Reactive Protein and its Interactions With Other Relevant Factors
Conclusions: Increased CRP was associated with cognitive impairment, and additive effects of increased CRP with hypertriglyceridemia and hyperglycemia on cognitive impairment were observed among elderly individuals. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Chen, J.-M., Cui, G.-H., Jiang, G.-X., Xu, R.-F., Tang, H.-D., Wang, G., Chen, S.-D., Cheng, Q. Tags: Current Topics in Research Source Type: research

Meta-Analysis of the Association Between Polymorphisms of Estrogen Receptor {alpha} Genes rs9340799 and rs2234693 and Alzheimer's Disease: Evidence From 23 Articles
Conclusions: This meta-analysis suggested that x allele of rs9340799 might have a protective effect on the risk of AD in Asia and in patients with SAD. In addition, the p allele of rs2234693 might decrease the risk of patients with SAD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Pan, Y., Li, Y., Shen, H. Tags: Current Topics in Research Source Type: research

Sonas: A Pilot Study Investigating the Effectiveness of an Intervention for People With Moderate to Severe Dementia
Conclusions: Sonas sessions did not lead to improvements in QoL and behavioral and psychological symptoms of dementia. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Hutson, C., Orrell, M., Dugmore, O., Spector, A. Tags: Current Topics in Research Source Type: research

Impact of Amyloid {beta}25-35 on Membrane Stability, Energy Metabolism, and Antioxidant Enzymes in Erythrocytes
Amyloid β25-35 (Aβ25-35) represents a neurotoxic fragment of Aβ1 - 40 or Aβ1 - 42, and is implicated in the progressive neurodegeneration in cases of the Alzheimer disease (AD). Amyloid β25-35 was shown to lyse rat erythrocytes (RBCs) of all ages, and the extent of the RBC toxicity is directly correlated with Aβ25-35 concentration and cell age. Activities of glycolytic, antioxidant, and Na+/K+-adenosine triphosphatase (ATPase) enzymes, in vivo, are significantly decreased in older RBCs as compared to the young RBCs. In vitro, A&be...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Tikhonova, L. A., Kaminsky, Y. G., Reddy, V. P., Li, Y., Solomadin, I. N., Kosenko, E. A., Aliev, G. Tags: Current Topics in Research Source Type: research

"I'm a Storyteller!": Exploring the Benefits of TimeSlips Creative Expression Program at a Nursing Home
Conclusion: Involvement in TimeSlips can engender benefits for residents, staff, and nursing home communities. Future research is needed to quantitatively assess whether the benefits noted in this study can longitudinally improve quality and lower cost of long-term care. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: George, D. R., Houser, W. S. Tags: Current Topics in Care Source Type: research

Prognosis of Short Survival in Patients With Advanced Dementia as Diagnosed by Aminoff Suffering Syndrome
On the first few days after admission to the Geriatric-Internal Medicine department, the suffering level of patients with advanced dementia (Mini-Mental State Examination 0 of 30) was evaluated according to the Mini-Suffering State Examination (MSSE). During hospitalization, 14.8% (27 of 183) of patients with advanced dementia were died with a mean survival rate of 19.86 ± 26.9 days. The MSSE scale score of died patients was 7.56 ± 1.71 during the first few days of admission which indicates high suffering levels. The MSSE scale score of survived patients with advanced dementia was 3.99 ± 2.10 which con...
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Aminoff, B. Z. Tags: Current Topics in Care Source Type: research

Needs Assessments of Memory Disorder Patients
Conclusions: This study satisfied the initial identification of caregiver and patient needs; now each must be explored further to determine how to successfully meet such needs. If the primary needs of the patient can be met by a focused service, the caregiver will no longer be the sole provider of meeting the specific need. This will decrease the involved role of the caregiver, maximize patient homecare, minimize caregiver stress, and increase the quality of life for both the patient and caregiver. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - November 18, 2014 Category: Geriatrics Authors: Bowen, K. J., Gonzalez, E. W., Edwards, C. Y., Lippa, C. F. Tags: Current Topics in Care Source Type: research