American Journal of Alzheimer's Disease and Other Dementias This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Clinical Correlates of Unawareness of Deficits Among Patients With Dementia Due to Alzheimer's Disease
Conclusion: Unawareness of deficits among patients with AD was common. The 2 domains of unawareness showed different characteristics and may possibly present different etiologies. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Chen, Y.-L., Chen, H.-M., Huang, M.-F., Yeh, Y.-C., Yen, C.-F., Chen, C.-S. Tags: Current Topics in Research Source Type: research

Gene Expression Profiles of Entorhinal Cortex in Alzheimer's Disease
This study aimed to analyze the differentially expressed genes (DEGs) in entorhinal cortex with AD and identify featured genes related to AD. Gene expression profile GSE5281 was downloaded from Gene Expression Omnibus, including 10 AD and 13 control samples. Differentially expressed genes were identified by Student t test including 119 upregulated and 591 downregulated DEGs. Then, we obtained 14 enrichment Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways among which 11 pathways were significantly enriched (adjusted P value < .05). The KEGG pathway network which was constructed by 14 KEGG pathways showed that 6-ph...
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Ding, B., Xi, Y., Gao, M., Li, Z., Xu, C., Fan, S., He, W. Tags: Current Topics in Research Source Type: research

Vascular Risk Factors Aggravate the Progression of Alzheimer's Disease: A 3-Year Follow-Up Study of Chinese Population
Conclusions: Vascular risk factors are common comorbidities in patients with AD in China, with younger, better educated ones showing faster cognitive decline. Hypertension and hyperhomocysteinemia may also aggravate the progression, and it is important to prevent and treat patients with AD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Qiao, J., Lu, W.-H., Wang, J., Guo, X.-J., Qu, Q.-M. Tags: Current Topics in Research Source Type: research

Ms L: A Case of a Reversible Phenotypic and Brain Function Equivalent of Frontotemporal Dementia
Frontotemporal dementia (FTD) is second only to Alzheimer’s disease in individuals younger than 65 years of age. Behavioral variant FTD (bvFTD) presents with nonspecific symptoms such as disinhibition, apathy, or emotional blunting. Although neuropsychological testing and structural neuroimaging are not very helpful in diagnosing bvFTD in its initial stages, newer quantitative structural methods and functional neuroimaging have better sensitivity and specificity. Ms L presented with blunted affect, disinhibition, impairments in insight, planning ability and social comportment, changed dietary habits, and episodes of ...
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Tanev, K. S., Vento, J. A. Tags: Current Topics in Care Source Type: research

Cognitive Stimulation for Portuguese Older Adults With Cognitive Impairment: A Randomized Controlled Trial of Efficacy, Comparative Duration, Feasibility, and Experiential Relevance
Although some studies point to cognitive stimulation as a beneficial therapy for older adults with cognitive impairments, this area of research and practice is still lacking dissemination and is underrepresented in many countries. Moreover, the comparative effects of different intervention durations remain to be established and, besides cognitive effects, pragmatic parameters, such as cost-effectiveness and experiential relevance to participants, are seldom explored. In this work, we present a randomized controlled wait-list trial evaluating 2 different intervention durations (standard = 17 vs brief = 11 sessions) of a cog...
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Alves, J., Alves-Costa, F., Magalhaes, R., Goncalves, O. F., Sampaio, A. Tags: Current Topics in Care Source Type: research

Periodontal Health Condition in Patients With Alzheimer's Disease
Conclusion: The periodontal health status ofindividuals with AD deteriorates with disease progression and was closely related to their cognitive function. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Martande, S. S., Pradeep, A. R., Singh, S. P., Kumari, M., Suke, D. K., Raju, A. P., Naik, S. B., Singh, P., Guruprasad, C. N., Chatterji, A. Tags: Current Topics in Care Source Type: research

Clinical Significance in Dementia Research: A Review of the Literature
The objective of this study was to provide a critical overview of the current approaches to measuring clinical significance in dementia research and to provide suggestions for future research. A systematic search was conducted of Medline and Embase for original, English-language, peer-reviewed articles published before July 2012. A total of 18 articles met the inclusion criteria, of which 13 used multiple approaches to measure clinical significance. In all, 5 articles used expert opinion as anchors; 4 also used distribution-based approaches. In all, 8 articles used Goal Attainment Scaling; 7 of these also relied on clinici...
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Shabbir, S. H., Sanders, A. E. Tags: Review Source Type: research

New York Can be Our Nation's Center for Alzheimer's Research
More than 5 million people in this country have Alzheimer's disease, and more than 300,000 of those with Alzheimer's live in New York. By 2025, it is estimated that there will be 350,000 residents living with Alzheimer's in New York. Congressman Steve Israel and New York Assemblyman Charles Lavine issued a joint proposal in June, 2013 suggesting that New York become this country's center for Alzheimer's research. Obviously, they would both like to see increased federal funding, but they also know that we cannot count on that happening. So Israel and Lavine have proposed a $3 billion state bonding initiative to secure suff...
Source: American Journal of Alzheimer's Disease and Other Dementias - September 10, 2014 Category: Geriatrics Authors: Vann, A. S. Tags: Thoughts, Opinions, and Controversies Source Type: research

Magnetic Resonance Spectroscopy Study of Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment With No Dementia
In this study, a 2-dimensional magnetic resonance spectroscopy was performed in 25 patients with aMCI, 28 patients with VCIND, and 32 normal controls (NCs). The concentrations of N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI), and creatine (Cr) were measured, and their ratios were calculated. The patients with aMCI displayed significantly lower NAA/MI bilaterally in the posterior cingulate gyrus (PCG) and white matter of occipital lobe (OLWM) than NC participants or patients with VCIND , whereas patients with VCIND displayed markedly lower NAA/Cho bilaterally in the white matter of frontal lobe (FLWM) and left O...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Liu, Y.-Y., Yang, Z.-X., Shen, Z.-W., Xiao, Y.-Y., Cheng, X.-F., Chen, W., Chen, Y.-W., Wu, R.-H. Tags: Current Topics in Research Source Type: research

Effects of Multisensory Stimulation on a Sample of Institutionalized Elderly People With Dementia Diagnosis: A Controlled Longitudinal Trial
Long-term effects of multisensory stimulation were assessed using a "Snoezelen" room on older residents with dementia. Thirty patients were randomly assigned to 3 groups: multisensory stimulation environment (MSSE) group, individualized activities (activity) group, and control group. The MSSE and activity groups participated in two 30-minute weekly individualized intervention sessions over 16 weeks. Pre-, mid-, posttrial, and 8-week follow-up behavior, mood, cognitive, and functional impairment in basic activities of daily living were registered. Items included in the physically nonaggressive behavior factor improved signi...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Maseda, A., Sanchez, A., Marante, M. P., Gonzalez-Abraldes, I., Bujan, A., Millan-Calenti, J. C. Tags: Current Topics in Research Source Type: research

Affect Balance and Relationship With Well-Being in Nursing Home Residents With Dementia
The purpose of this exploratory study was to determine whether the balance of positive to negative affect can discriminate states of well-being in nursing home residents with dementia and whether affect balance is associated with activity engagement. Baseline data from a randomized clinical trial were used in this secondary analysis. Participants were 128 residents recruited from 9 nursing homes located in Pennsylvania. Participants were primarily female, Caucasian, and had a mean age of 86 years. Measures of agitation and affect were taken from video recordings of 10 observational sessions. Measures of engagement and self...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Kolanowski, A. M., Van Haitsma, K., Meeks, S., Litaker, M. Tags: Current Topics in Research Source Type: research

Gastritis May Boost Odds of Dementia
Conclusions: The findings from this population-based observational study showing evidence that gastritis may increase the risk of dementia provide avenue for further inquiries into dementia. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Momtaz, Y. A., Hamid, T. A., Ibrahim, R. Tags: Current Topics in Research Source Type: research

Medical Resource Value Appraisal for Leucojum aestivum in Turkey
In this study, we investigate the medical and economical value of Leucojum aestivum. Leucojum aestivum contains the alkaloid galanthamine, which is one of the main active substances in Reminyl, a commonly used drug for the treatment of Alzheimer’s disease (AD). In this analysis, we estimate that there are 13 million mild to moderate patients with Alzheimer’s who use Reminyl. Our results suggest that the market change value of L aestivum required for 1 unit of Reminyl is US$62. The value of total change of galanthamine and L aestivum is estimated to be US$18.6 billion per year. Alzheimer’s drugs that use L...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Demir, A. Tags: Current Topics in Research Source Type: research

More Education May Limit Disability and Extend Life For People With Cognitive Impairment
We examined associations among education, disability, and life expectancy for people with cognitive impairment, following a 1992 cohort ages 55+ for 23 063 person-years (Panel Study of Income Dynamics, n = 2165). We estimated monthly probabilities of disability and death for 7 education levels, adjusting for age, gender, ethnicity, and cognitive status. We used the probabilities to simulate populations with age-specific cognitive impairment incidence and monthly disability status through death. For those with cognitive impairment, education was associated with longer life and less disability. Among them, college-educated w...
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Laditka, S. B., Laditka, J. N. Tags: Current Topics in Research Source Type: research

A Novel Presenilin 1 Mutation in Early-Onset Alzheimer's Disease With Prominent Frontal Features
Familial Alzheimer’s disease (AD) is a rare disorder involving known autosomal dominant mutations in the amyloid precursor protein and presenilin (PSEN) 1 and 2. Here, we present a case of early-onset AD with prominent frontal features associated with a novel deletion of codon 40 in the PSEN1 gene. Serial brain magnetic resonance imaging and 18F florbetapir imaging show prominent involvement of the frontal lobes, corresponding with the clinical presentation. This case report illustrates a possible link between a novel PSEN1 mutation and frontal variant AD. (Source: American Journal of Alzheimer's Disease and Other Dementias)
Source: American Journal of Alzheimer's Disease and Other Dementias - July 15, 2014 Category: Geriatrics Authors: Nygaard, H. B., Lippa, C. F., Mehdi, D., Baehring, J. M. Tags: Current Topics in Research Source Type: research