Two case reports of desensitization in patients with hypersensitivity to iron
ConclusionIron deficiency anemia is a disease that can significantly compromise the quality of life of patients. The desensitization protocol for patients with hypersensitivity to iron is a safe and effective treatment option for patients with a history of allergy to intravenous iron. This case report shows the usefulness to use the desensitization protocol for patients with hypersensitivity to iron. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 10, 2017 Category: Allergy & Immunology Source Type: research
Checklist for a complete chronic urticaria medical history: an easy tool
ConclusionsOur guide provides an easy-to-use tool to support clinicians to focus, orient themselves, and save time in medical consultations for CU, allowing better diagnosis and management of this disease. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 3, 2017 Category: Allergy & Immunology Source Type: research
Debates in Allergy Medicine: Allergy skin testing cannot be replaced by molecular diagnosis in the near future
In conclusion: as of now these techniques should be reserved for situations of complex allergies and polysensitization; in the future MA-Dx might help to reduce the number of allergens for AIT, but trials are needed to prove this concept. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - September 19, 2017 Category: Allergy & Immunology Source Type: research
Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
AbstractIn today ’s clinical practice patients’ skin is used as screening organ for diagnosing type 1 allergy. According to European guidelines skin prick testing with a panel of 18 allergen extracts is recommended, in the US between 10 to 50 allergens are used. The specificity and sensitivity of skin testing is individually highly variable depending on age, body mass, and skin barrier status. In atopic inflammation skin testing gives more false positive results. Smaller skin area and strain limits prick testing in small children. Although the risk for systemic reactions in skin prick testing is very small , emergency ...
Source: World Allergy Organization Journal - September 19, 2017 Category: Allergy & Immunology Source Type: research
The grass pollen season 2015: a proof of concept multi-approach study in three different European cities
ConclusionThe phenological observations, pollen measurements and symptom data evaluation provided unique insights into the contribution of multiple grass species in different European regions. All investigated grass species in the provocation induced rhinitis symptoms of comparable significance, with some degree of variation in symptom patterns. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - September 11, 2017 Category: Allergy & Immunology Source Type: research
A 17-year-old male with a Small Bowel Neuroendocrine Tumor: flushing differential diagnosis
ConclusionsNETs can present as carcinoid syndrome (flushing, diarrhea, abdominal pain, wheezing), which constitutes vague symptomatology and represents a challenging diagnosis for physicians. They can be confused with an allergic reaction and the allergist should consider it as a differential diagnosis. Accurate diagnostic tests will help to diagnose NETs earlier and potentially prevent carcinoid heart disease, bowel obstruction, and improve quality of life and mortality in these patients. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - September 4, 2017 Category: Allergy & Immunology Source Type: research
The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming
AbstractSkin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. As our primary interface with the external environment, the bio...
Source: World Allergy Organization Journal - August 22, 2017 Category: Allergy & Immunology Source Type: research
Severe asthma and quality of life
This article briefly reviews the impact of severe asthma on QOL and the potential methods to combat this morbidity including the available therapeutic biologics. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 21, 2017 Category: Allergy & Immunology Source Type: research
Allergic profiles of mothers and fathers in the Japan Environment and Children ’s Study (JECS): a nationwide birth cohort study
ConclusionsThis is the first epidemiological report on allergic disorders and allergen sensitization of parents during pregnancy among the Japanese general population. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 7, 2017 Category: Allergy & Immunology Source Type: research
A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis
ConclusionsThere is evidence to consider use of pHF as an option for reducing the risk of any allergic diseases, particularly eczema. However, the certainty of the evidence is low. One characteristic that makes our meta-analysis distinct from other reviews is that it focuses exclusively on only one type of pHF. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 26, 2017 Category: Allergy & Immunology Source Type: research
Is peanut causing food allergy in Cuba? Preliminary assessment of allergic sensitization and IgE specificity profile to peanut allergens in Cuban allergic patients
ConclusionsSensitization to peanut allergen is indeed relatively frequent in Cuba. The IgE profile is congruent to a sensitization pattern by ingestion of roasted peanuts and is directed to well-known major allergens. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 11, 2017 Category: Allergy & Immunology Source Type: research
Innate function of house dust mite allergens: robust enzymatic degradation of extracellular matrix at elevated pH
ConclusionsOur data highlight that D.p. is a robust source of several distinct enzymes with protease- andN-acetyl- β-hexosaminidase activities. In alkaline milieu they can degrade components of the ECM. Therefore, D.p. may contribute to epithelial barrier disruption especially when the skin surface pH is elevated. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 4, 2017 Category: Allergy & Immunology Source Type: research
Small airways disease and severe asthma
AbstractThe small airways of the lungs are commonly affected in pediatric and adult asthma. Small airways disease has been related to asthma control, severity, and risk of exacerbation. Diagnosis of small airways disease can be best made through evaluation of surgical lung specimens. Noninvasive techniques including spirometry, plethysmography, nitrogen washout, impulse oscillometry, and cross-sectional imaging have been utilized to assess and infer the extent of small airways disease in asthma and can be used longitudinally to assess response to treatment. Patients with small airways disease seem to benefit from inhaled a...
Source: World Allergy Organization Journal - June 21, 2017 Category: Allergy & Immunology Source Type: research
WAO International Scientific Conference (WISC 2016) Abstracts
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 20, 2017 Category: Allergy & Immunology Source Type: research
Randomised controlled trial of a baked egg intervention in young children allergic to raw egg but not baked egg
ConclusionOur study suggests that short term, regular consumption of BE by BE tolerant 1 to 5 year old children with IgE mediated raw egg allergy may not induce, accelerate or slow development of tolerance to raw egg in this selected population. Trials with larger sample sizes are required to further test this hypothesis.Trial RegistrationThe trial was registered on 7th February 2012 with the Australian New Zealand Clinical Trials Registry (ACTRN 12612000173897). (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 16, 2017 Category: Allergy & Immunology Source Type: research
