Allergenius, an expert system for the interpretation of allergen microarray results
Conclusions
Allergenius is a trustable ES dedicated to molecular tests for allergy. In the present version, it provides a powerful method to understand ISAC results and to obtain a comprehensive interpretation of the patient’s IgE profiling. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 25, 2014 Category: Allergy & Immunology Source Type: research
Happy 25th birthday, Bet v 1!
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 3, 2014 Category: Allergy & Immunology Source Type: research
Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma
Abstract
A pathological hallmark of asthma is chronic injury and repair, producing dysfunction of the epithelial barrier function. In this setting, increased oxidative stress, growth factor- and cytokine stimulation, together with extracellular matrix contact produces transcriptional reprogramming of the epithelial cell. This process results in epithelial-mesenchymal transition (EMT), a cellular state associated with loss of epithelial polarity, expression of mesenchymal markers, enhanced mobility and extracellular matrix remodeling. As a result, the cellular biology of the EMT state produces characteri...
Source: World Allergy Organization Journal - June 2, 2014 Category: Allergy & Immunology Source Type: research
International consensus on (ICON) anaphylaxis
Abstract
ICON: Anaphylaxis provides a unique perspective on the principal evidence-based anaphylaxis guidelines developed and published independently from 2010 through 2014 by four allergy/immunology organizations. These guidelines concur with regard to the clinical features that indicate a likely diagnosis of anaphylaxis -- a life-threatening generalized or systemic allergic or hypersensitivity reaction.
They also concur about prompt initial treatment with intramuscular injection of epinephrine (adrenaline) in the mid-outer thigh, positioning the patient supine (semi-reclining if dy...
Source: World Allergy Organization Journal - May 30, 2014 Category: Allergy & Immunology Source Type: research
Allergic diseases and asthma: a global public health concern and a call to action
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - May 19, 2014 Category: Allergy & Immunology Source Type: research
Immunological cross-reactivity between olive and grass pollen: implication of major and minor allergens
Conclusion
No in vitro cross-reactivity was observed when sIgE was mainly directed to major allergens. In our population, sensitization to olive and grasses is not due to cross-reactivity. The contribution of the major allergens seems to be determinant. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - May 8, 2014 Category: Allergy & Immunology Source Type: research
Precautionary labelling of foods for allergen content: are we ready for a global framework?
This article outlines the current status of allergen labelling legislation around the world and reviews the value of current existing precautionary allergen labelling for the allergic consumer. We strongly urge for an international framework to be considered to help roadmap a solution to the weaknesses of the current systems, and discuss the role of legislation in facilitating this. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 30, 2014 Category: Allergy & Immunology Source Type: research
AQUA© as predictor of allergy in elite marathon runners
Conclusions
This study demonstrates that AQUA© can be used to predict allergy in elite marathon runners. In addition, these athletes have a higher prevalence of allergy symptoms to elite athletes from other sports. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 3, 2014 Category: Allergy & Immunology Source Type: research
Sublingual immunotherapy: World Allergy Organization position paper 2013 update
Abstract
We have prepared this document, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2013 Update”, according to the evidence-based criteria, revising and updating chapters of the originally published paper, “Sublingual Immunotherapy: World Allergy Organization Position Paper 2009”, available at http://www.waojournal.org. Namely, these comprise: “Mechanisms of sublingual immunotherapy;” “Clinical efficacy of sublingual immunotherapy” – reporting all the data of all controlled trials published after 2009; “Safety of sublingual immunotherapy” – with the rece...
Source: World Allergy Organization Journal - March 28, 2014 Category: Allergy & Immunology Source Type: research
Setting the stage of innovations in allergy globally
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - March 21, 2014 Category: Allergy & Immunology Source Type: research
Off-label prescribing for allergic diseases in children
Abstract
The majority of drugs prescribed have not been tested in children and safety and efficacy of children’s medicines are frequently supported by low quality of evidence. Therefore, a large percentage of prescriptions for children in the clinical daily practice are used off label. Despite the several recent legislation and regulatory efforts performed worldwide, they have not been successful in increasing availability of medicines adapted to children. Moreover, if we consider that 30% of the prescribed drugs for children are for the respiratory field and only 4% of new investigation projects for ...
Source: World Allergy Organization Journal - February 14, 2014 Category: Allergy & Immunology Source Type: research
Poster 2001: Generation a hypoallergenic profilin from amaranthus palmeri pollen
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - February 3, 2014 Category: Allergy & Immunology Source Type: research
