Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement
AbstractOne of the major concerns in the practice of allergy is related to the safety of procedures for the diagnosis and treatment of allergic disease. Management (diagnosis and treatment) of hypersensitivity disorders involves often intentional exposure to potentially allergenic substances (during skin testing), deliberate induction in the office of allergic symptoms to offending compounds (provocation tests) or intentional application of potentially dangerous substances (allergy vaccine) to sensitized patients. These situations may be associated with a significant risk of unwanted, excessive or even dangerous reactions,...
Source: World Allergy Organization Journal - October 11, 2016 Category: Allergy & Immunology Source Type: research
Proceedings of the 2015 WAO Symposium on Food Allergy and the Microbiome
Table of contentsA1 Characterization of the immunoallergic profile towards the proteins of the wheat flour in Cuban populationRa úl Lázaro Castro Almarales, Mary Carmen Reyes Zamora, Beatriz Tamargo, Damaris Torralba Averoff, Raysa Cruz, Yunia Oliva Diaz, Mirta Alvarez Castello, Alexander Ciria, Alexis Labrada, Maytee MateoA2 Are peanuts causing food allergy in Cuba?Maytee Mateo, Damaris Torralba Averoff, Raysa Cruz, Yunia Oliva Diaz, Mirta Alvarez Castello, Alexander Ciria, Mary Carmen Reyes Zamora, Beatriz Tamargo, Alexis LabradaA3 Prick test and immunoallergic profile to soy allergens in Cuban populationOmar Herrera, ...
Source: World Allergy Organization Journal - October 10, 2016 Category: Allergy & Immunology Source Type: research
Heated egg yolk challenge predicts the natural course of hen ’s egg allergy: a retrospective study
ConclusionsClassifying infants who are allergic to hen ’s egg into EYSEW tolerant and EYSEW reactive groups was useful in determining prognosis. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 5, 2016 Category: Allergy & Immunology Source Type: research
International Consensus (ICON): allergic reactions to vaccines
ConclusionsThis document provides comprehensive and internationally accepted guidelines and access to on-line documents to help practitioners around the world identify allergic reactions following immunization. It also provides a framework for the evaluation and further management of patients who present either following an allergic reaction to a vaccine or with a history of allergy to a component of vaccines. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - September 15, 2016 Category: Allergy & Immunology Source Type: research
Tiotropium in asthma: what is the evidence and how does it fit in?
AbstractDespite current therapeutic approaches asthma remains uncontrolled in a significant proportion of patients. Short-acting anticholinergic bronchodilators have a very long history of use in asthma, and recent data confirms the importance of acetylcholine as both a bronchoconstrictor and as a regulator of inflammation and remodeling in the lungs. Data from a comprehensive clinical trial programme, as well as use in primary care, show the efficacy and safety of tiotropium in adults with mild to moderate asthma when it is added to ICS and in severe asthma when it is added to high doses of ICS plus LABA, as well as in ad...
Source: World Allergy Organization Journal - September 13, 2016 Category: Allergy & Immunology Source Type: research
Exposure to positively- and negatively-charged plasma cluster ions impairs IgE-binding capacity of indoor cat and fungal allergens
ConclusionThese results suggest that environmental control with PC-ions is useful for inactivation of indoor cat and fungal allergens. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - September 5, 2016 Category: Allergy & Immunology Source Type: research
Prevention of food and airway allergy: consensus of the Italian Society of Preventive and Social Paediatrics, the Italian Society of Paediatric Allergy and Immunology, and Italian Society of Pediatrics
ConclusionsThe recommendations of the Consensus are based on a careful analysis of the evidence available.The lack of evidence of efficacy does not necessarily imply that some interventions may not be effective, but currently they can ’t be recommended. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 17, 2016 Category: Allergy & Immunology Source Type: research
The use of inhaled corticosteroids in pediatric asthma: update
This article reviews the key mechanisms of inhaled corticosteroid action; recommendations on dosage and therapeutic regimens; potential optimization of effectiveness by addressing inhaler technique and adherence to therapy; and updated knowledge on the real magnitude of adverse events. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 11, 2016 Category: Allergy & Immunology Source Type: research
Dissemination of definitions and concepts of allergic and hypersensitivity conditions
ConclusionThis current review intends to be accepted and used universally by all health professionals involved in diseases ’ classification and coding and, therefore, contribute to improve care and outcomes in this increasing sub-section of the world’s population. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 8, 2016 Category: Allergy & Immunology Source Type: research
Assessing worldwide research activity on probiotics in pediatrics using Scopus database: 1994 –2014
Conclusions < /h3 > < p class= " a-plus-plus " > Interest in probiotic research and its potential benefits in pediatric ailments is relatively recent but significantly increasing. Bibliometric analysis can be used as an indicator of the importance and growth of probiotic use in pediatrics. < /p > < /span > (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 24, 2016 Category: Allergy & Immunology Source Type: research
Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models
Abstract
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus and commonly classified as a Th2-type allergy. Major advances in our understanding of the EoE pathophysiology have recently been made, but clinicians struggle with highly unpredictable therapy responses indicative of phenotypic diversity within the patient population. Here, we summarize evidences for the existence of EoE subpopulations based on diverse inflammatory characteristics of the esophageal tissue in EoE. Additionally, clinical characteristics of EoE patients support the concept of disease subtypes. We co...
Source: World Allergy Organization Journal - July 14, 2016 Category: Allergy & Immunology Source Type: research
Successful use of cyclosporine as treatment for eosinophilic cystitis: a case report
Conclusion
This case illustrates the utility of using cyclosporine to treat eosinophilic cystitis in adult patient with multiple comorbid conditions. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - July 7, 2016 Category: Allergy & Immunology Source Type: research
Particularities of allergy in the Tropics
Abstract
Allergic diseases are distributed worldwide and their risk factors and triggers vary according to geographical and socioeconomic conditions. Allergies are frequent in the Tropics but aspects of their prevalence, natural history, risk factors, sensitizers and triggers are not well defined and some are expected to be different from those in temperate zone countries. The aim of this review is to investigate if allergic diseases in the Tropics have particularities that deserve special attention for research and clinical practice. Such information will help to form a better understanding of the path...
Source: World Allergy Organization Journal - June 26, 2016 Category: Allergy & Immunology Source Type: research
Eosinophilic bioactivities in severe asthma
Abstract
Asthma is clearly related to airway or blood eosinophilia, and asthmatics with significant eosinophilia are at higher risk for more severe disease. Eosinophils actively contribute to innate and adaptive immune responses and inflammatory cascades through the production and release of diverse chemokines, cytokines, lipid mediators and other growth factors. Eosinophils may persist in the blood and airways despite guidelines-based treatment. This review details eosinophil effector mechanisms, surface markers, and clinical outcomes associated with eosinophilia and asthma severity. There is interest ...
Source: World Allergy Organization Journal - June 26, 2016 Category: Allergy & Immunology Source Type: research
Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients
Conclusions
Approximately one-third of children experienced ≥ 1 exacerbation in real-world clinical practice. A targeted treatment approach with a focus on those with a history of recurrent exacerbations is recommended to improve asthma control. This targeted approach could also minimise the frequent systemic corticosteroid exposure particularly at an early age when side effects of systemic corticosteroids are more pronounced. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 5, 2016 Category: Allergy & Immunology Source Type: research
