Effects of environment on human cytokine responses during childhood in the tropics: role of urban versus rural residence
Conclusions
In our study population, the immune response of children living in an urban environment was associated more frequently with the production of the immune regulatory cytokine, IL-10. Some factors related to poor hygiene and living conditions were associated with elevated IL-10 production within urban and rural populations. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - August 6, 2015 Category: Allergy & Immunology Source Type: research
Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants
Abstract
The purpose of this brief communication is to highlight emerging evidence to existing guidelines regarding potential benefits of supporting early, rather than delayed, peanut introduction during the period of complementary food introduction in infants. This document should be considered as interim guidance based on consensus among the following organizations: American Academy of Allergy, Asthma & Immunology; American Academy of Pediatrics; American College of Allergy, Asthma & Immunology; Australasian Society of Clinical Immunology and Allergy; Canadian Society of Allergy and Clinical I...
Source: World Allergy Organization Journal - August 3, 2015 Category: Allergy & Immunology Source Type: research
Molecular, proteomic and immunological parameters of allergens provide inclusion criteria for new candidates within established grass and tree homologous groups
Conclusion
MS allows the possibility to identify individual proteins or allergens from complex mixes by mass and/or sequence, and this has been extensively applied to the allergen field. New data on the homology, cross-reactivity and biological parameters of allergen sources have been considered to extend the work of Lorenz et al., 2009 in the context of tree and grass species. The concept of homologous groups is certainly dynamic allowing the flexibility and potential in streamlining quality parameters, such as stability profiles, due to extrapolation of exemplar data to a wider range of allergens. (...
Source: World Allergy Organization Journal - July 16, 2015 Category: Allergy & Immunology Source Type: research
Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization
Abstract
The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with developing countries being at the core of these changes. Around the planet, in both developed and developing countries, environments are undergoing profound changes. Many of these changes are considered to have negative effects on resp...
Source: World Allergy Organization Journal - July 14, 2015 Category: Allergy & Immunology Source Type: research
Oral immunotherapy and anti-IgE antibody treatment for food allergy
Abstract
Food allergy is a major public health problem affecting nearly 10 % of children in most industrialized countries. Unfortunately, there are no effective therapies for food allergy, relegating patients to simply avoid the offending foods and treat reactions that occur on accidental exposure. Recently however, studies suggest that food immunotherapy may provide a promising new approach to food allergy, particularly using the oral form of immunotherapy (OIT). Enthusiasm for this approach though must be tempered because of the significant allergic reactions that often occur with OIT that tends to li...
Source: World Allergy Organization Journal - July 6, 2015 Category: Allergy & Immunology Source Type: research
The microbiome of the human lower airways: a next generation sequencing perspective
Abstract
For a long time, the human lower airways were considered a sterile environment where the presence of microorganisms, typically revealed by culturing, was interpreted as an abnormal health state. More recently, high-throughput sequencing-based studies have led to a shift in this perception towards the notion that even in healthy conditions the lower airways show either transient presence or even permanent colonization by microorganisms. However, challenges related to low biomass and contamination in samples still remain, and the composition, structure and dynamics of such putative microbial comm...
Source: World Allergy Organization Journal - June 16, 2015 Category: Allergy & Immunology Source Type: research
Genetic, familial and environmental correlates of asthma among early adolescents in Sri Lanka: a case control study
Conclusion
A significant proportion of students reported to have asthma. Atopy and other genetic and environmental correlates should be considered as important correlates in asthma management among early adolescents in Sri Lanka. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 16, 2015 Category: Allergy & Immunology Source Type: research
Catching allergy by a simple questionnaire
Conclusions
These findings show that RAP test can be proposed as an useful tool to be used by physician other than allergists when evaluating patients with rhinitis, suggesting the need of allergy testing. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 11, 2015 Category: Allergy & Immunology Source Type: research
Chronic urticaria merits serum vitamin D evaluation and supplementation; a randomized case control study
Conclusions
CU patients have low serum 25(OH)2D levels and Vit-D3 supplementation in combination with antihistamine and systemic corticosteroid show elevated response in resolving the symptoms of CU. This study also warrants that each subject with CU should be screened for serum 25 (OH)2D levels before starting a treatment. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - June 4, 2015 Category: Allergy & Immunology Source Type: research
How an online survey on the treatment of allergic rhinitis and its impact on asthma (ARIA) detected specialty-specific knowledge-gaps
Conclusion
On certain issues in the treatment of AR the physicians’ opinion diverges from the recommendations/suggestions of ARIA experts. Moreover, physicians’ opinions depend on their specialty. As such, an online survey can help to detect knowledge-gaps and guide the development of more focused and specialty-specific postgraduate learning tools. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - May 19, 2015 Category: Allergy & Immunology Source Type: research
Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens
Abstract
Substantial progress in understanding mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumors, organ transplantation and chronic infections has led to a variety of targeted therapeutic approaches. Allergen-specific immunotherapy (AIT) has been used for 100 years as a desensitizing therapy for allergic diseases and represents the potentially curative and specific way of treatment. The mechanisms by which allergen-AIT has its mechanisms of action include the very early desensitization effects, modulation of T- and B-cell responses and related antibody isotypes as well as ...
Source: World Allergy Organization Journal - May 14, 2015 Category: Allergy & Immunology Source Type: research
Budesonide inhalation suspension versus methylprednisolone for treatment of moderate bronchial asthma attacks
Conclusion
In patients with recurrent wheezing or bronchial asthma of <5 years, the efficacy of BIS is equivalent or better than mPSL for moderate bronchial asthma attacks, and in contrast to steroid treatment, BIS treatment do not suppress adrenocortical function. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - May 5, 2015 Category: Allergy & Immunology Source Type: research
Severity of allergic rhinitis and asthma development in children
Abstract
Allergic rhinitis (AR) is a relevant risk factor for the development of asthma in children. We recruited a cohort of 104 children with AR and re-evaluated them after 5 years. We considered the ARIA classification. All patients, who had moderate to severe persistent AR at baseline, developed asthma symptoms. These results strongly indicate that the severity of AR may be an important factor that increases the risk of asthma development in children. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 23, 2015 Category: Allergy & Immunology Source Type: research
Urticarial vasculitis induced by OTC diet pills: a case report
Conclusion
OTC diet pills are widely available worldwide, and due to its widespread use, allergologists and dermatologist should be able to recognize symptoms and lesions of cutaneous vasculitis, which may be under reported. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 16, 2015 Category: Allergy & Immunology Source Type: research
Intermittent and episode-driven use of pranlukast to reduce the frequency of wheezing in atopic children: a randomized, double-blind, placebo-controlled trial
Conclusions
These results suggest that intermittent and episode-driven use of pranlukast in small children with a prior history of wheezing and atopic sensitization may not reduce the frequency of wheezing later in life. However, the sample size was too small to make a definitive conclusion.
Trial registration
UMIN000000634 (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - April 2, 2015 Category: Allergy & Immunology Source Type: research
