The international survey on the management of allergic rhinitis by physicians and patients (ISMAR)
Abstract
Epidemiologic studies suggest that the prevalence of allergic rhinitis (AR) is rising worldwide. Several reports, in fact, indicate increasing trends in the prevalence of AR especially in developing countries, likely related to the environment and climate changes and the adoption of an urbanized Western lifestyle. The primary objective of the present study was to collect information about management in real-life settings, including a characterization of typical patients’ profile referring to physicians, the disease features, the common approaches to diagnostic assessments and therapeutic deci...
Source: World Allergy Organization Journal - March 20, 2015 Category: Allergy & Immunology Source Type: research
Intralymphatic immunotherapy
Abstract
Gold Standard allergen-specific immunotherapy is associated with low efficacy because it requires either many subcutaneous injections of allergen or even more numerous sublingual allergen administrations to achieve amelioration of symptoms. Intralymphatic vaccination can maximize immunogenicity and hence efficacy. We and others have demonstrated that as few as three low dose intralymphatic allergen administrations are sufficient to effectively alleviate symptoms. Results of recent prospective and controlled trials suggest that this strategy may be an effective form of allergen immunotherapy. (S...
Source: World Allergy Organization Journal - March 7, 2015 Category: Allergy & Immunology Source Type: research
The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity
Conclusions
In this tropical population, IgE sensitization to Ascaris and the cross-reactive tropomyosins was frequent and associated with clinical indicators of asthma severity. The significant relationship between sensitization to the nematode-specific marker Asc s 1 and ER attendance supports these findings. Moreover, ascariasis increases the human IgE responses to HDM specific allergens. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - March 3, 2015 Category: Allergy & Immunology Source Type: research
Aluminium in Allergies and Allergen immunotherapy
Abstract
Aluminium is a hot topic in the current debate. Exposure occurs due to environmental, dietary and intentional exposure to aluminium, such as in vaccines where it was introduced in 1926. In spite of the fact that it is a typical Th2 adjuvant, aluminium redirects the immune response in systemic allergen immunotherapy (SIT) upon prolonged immunization. SIT in the US, and SLIT in general, are at present non-adjuvanted therapies, but in Europe aluminium is used as adjuvant in most SIT preparations. It enhances the safety of SIT by local deposition of the allergen. Undesired properties of aluminium a...
Source: World Allergy Organization Journal - February 28, 2015 Category: Allergy & Immunology Source Type: research
Reviewer acknowledgement 2014
Contributing reviewers
The editors of World Allergy Organization Journal would like to thank all of our reviewers who have contributed to the journal in Volume 7 (2014). (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - February 13, 2015 Category: Allergy & Immunology Source Type: research
The care pathway for children with urticaria, angioedema, mastocytosis
Abstract
Cutaneous involvement characterized by urticarial lesions with or without angioedema and itch is commonly observed in routine medical practice. The clinical approach may still remain complex in real life, because several diseases may display similar cutaneous manifestations. Urticaria is a common disease, characterized by the sudden appearance of wheals, with/without angioedema. The term Chronic Urticaria (CU) encompasses a group of conditions with different underlying causes and different mechanisms, but sharing the clinical picture of recurring wheals and/or angioedema for at least 6 weeks. ...
Source: World Allergy Organization Journal - February 2, 2015 Category: Allergy & Immunology Source Type: research
World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics
Conclusions
WAO recommendations about probiotic supplementation for prevention of allergy are intended to support parents, clinicians and other health care professionals in their decisions whether to use probiotics in pregnancy and during breastfeeding, and whether to give them to infants. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 27, 2015 Category: Allergy & Immunology Source Type: research
The microbiome of the upper airways: focus on chronic rhinosinusitis
Abstract
Upper airway diseases including allergic rhinitis, chronic rhinosinusitis with or without polyps, and cystic fibrosis are characterized by substantially different inflammatory profiles. Traditionally, studies on the association of specific bacterial patterns with inflammatory profiles of diseases had been dependent on bacterial culturing. In the past 30 years, molecular biology methods have allowed bacterial culture free studies of microbial communities, revealing microbiota much more diverse than previously recognized including those found in the upper airway.
At presence,...
Source: World Allergy Organization Journal - January 26, 2015 Category: Allergy & Immunology Source Type: research
Non-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells
Conclusions
Pollen derived, non-allergenic factors reduce the dendritic cell’s expression of Th1 instructing Delta-like notch ligands and of MyD88, thereby promoting Th2 skewing of T helper cell responses. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 20, 2015 Category: Allergy & Immunology Source Type: research
A novel rapid (20-minute) IL-6 release assay using blood mononuclear cells of patients with various clinical forms of drug induced skin injuries
Conclusion
This rapid test is applicable to detect a wide scale of drug hypersensitivity. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 9, 2015 Category: Allergy & Immunology Source Type: research
Omalizumab vs. placebo in the management of chronic idiopathic urticaria: a systematic review
Conclusions and implications of the main findings
Despite the limitations, it is considered that omalizumab 300 mg is effective in treating chronic idiopathic urticaria refractory to H1 antihistamines. Further studies are required to determine the duration of effective treatment.
Registration number of the systematic review
CRD42014010029 (PROSPERO. International Prospective Register of Systematic Reviews). (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 31, 2014 Category: Allergy & Immunology Source Type: research
Vitamin D, allergies and asthma: focus on pediatric patients
Abstract
In recent years, the interest of the scientific world towards vitamin D gradually increased, and several studies have been conducted to dissect its possible role in modulating the development/course of allergic diseases. Also, Vitamin D supplementation has been assessed as a beneficial approach for treating allergies in some, but not all studies. We reviewed herein the available and relevant literature concerning the possible links between Vitamin D, its supplementation and allergic diseases. A literature search was made independently by the Authors, identifying articles for a narrative review....
Source: World Allergy Organization Journal - December 10, 2014 Category: Allergy & Immunology Source Type: research
Oral and sublingual immunotherapy for food allergy
Abstract
IgE-mediated food allergy is a potentially life-threatening allergic disease with an increase in prevalence in developed countries over the past 15 years. Currently, there are no approved forms of therapy and the standard of care is dietary restriction and ready access to emergency medications, such as self-injectable epinephrine and antihistamines. Allergen-specific modalities of treatment currently being studied include oral immunotherapy (OIT) and sublingual immunotherapy (SLIT). Both forms demonstrate the ability to desensitize patients to a variety of specific food allergens and show great...
Source: World Allergy Organization Journal - December 8, 2014 Category: Allergy & Immunology Source Type: research
Anti-IL5 therapy for asthma and beyond
Abstract
Airway inflammation is considered to be the primary component contributing to the heterogeneity and severity of airway disorders. Therapeutic efficacies of diverse novel biologics targeting the inflammatory pathways are under investigation. One such target is IL-5, a type-1 cytokine that is central to the initiation and sustenance of eosinophilic airway inflammation. Over the past decade, anti-IL5 molecules have been documented to have mixed therapeutic benefits in asthmatics. Post hoc analyses of the trials reiterate the importance of identifying the IL-5-responsive patient endotypes. In fact,...
Source: World Allergy Organization Journal - December 4, 2014 Category: Allergy & Immunology Source Type: research
A World Allergy Organization international survey on physical activity as a treatment option for asthma and allergies
Conclusions
The results of this global survey indicate that clinicians working in the field of allergy and respiratory diseases are well aware of the evidence supporting the benefits of physical activity for asthma and allergic diseases although they need more training in such counseling. Therefore, concerted efforts are needed towards educating clinicians towards promoting physical activity and weight management, as a supplementary treatment for asthma and allergies. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - November 27, 2014 Category: Allergy & Immunology Source Type: research
