Prime and boost aerosol exposure via fog machine or shisha smoke followed by cinnamon hypersensitivity and anaphylaxis to spiced food
Conclusion
From our data we conclude that hapten fragrances such as cinnamon aldehyde may during heating in glycerol fluids associate to complete antigens and via inspiration lead to specific immediate type hypersensitivity. In some cases the hypersensitivity may be unmasked by spiced food containing cinnamon aldehyde or related chemicals, and lead to severe adverse reactions. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 27, 2016 Category: Allergy & Immunology Source Type: research
Debates in allergy medicine: baked egg and milk do not accelerate tolerance to egg and milk
Abstract
There is emerging evidence that children with egg and cow’s milk allergy who can tolerate these allergens cooked in baked goods are more likely to develop tolerance. As a result a hypothesis has arisen that exposure to egg and milk in baked goods may hasten tolerance development; however, it is unclear whether children who develop tolerance do so because they have ingested low levels of egg or milk in baked products. An alternative explanation for the improved prognosis in those who can tolerate food allergens in the baked form is that tolerance to egg and milk in baked goods is simply an ind...
Source: World Allergy Organization Journal - January 26, 2016 Category: Allergy & Immunology Source Type: research
Debates in allergy medicine: baked milk and egg ingestion accelerates resolution of milk and egg allergy
This article will review our current understanding of baked milk and egg tolerance and outline how these baked forms accelerates tolerance to regular milk and egg. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 26, 2016 Category: Allergy & Immunology Source Type: research
Debates in allergy medicine: food intolerance does not exist
Conclusion
The term “intolerance” should not be used within the area of allergy. Intolerance should be better defined and the term restricted to some non-immunological/non-allergic diseases and not mixed with allergy, e.g. by using the term CMPA/I. A revision of the WAO nomenclature is proposed. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 14, 2015 Category: Allergy & Immunology Source Type: research
Asthma education material for children and their families; a global survey of current resources
Abstract
One of the keys to high quality paediatric asthma management is the provision of age appropriate information regarding the disease and its management. In order to determine whether the generation of a minimum dataset of information which can be translated into a wide range of languages might be used to assist children and their parents around the world, we undertook a survey of national Member Societies of the World Allergy Organization (WAO) to determine what educational material on asthma for children and their families already exists.
A questionnaire was developed using S...
Source: World Allergy Organization Journal - December 14, 2015 Category: Allergy & Immunology Source Type: research
Debates in allergy medicine: food intolerance does exist
Conclusion
“Food related symptom” should be used in each patient in which the pathophysiologic mechanism is not clear. Intolerance means a carbohydrate malabsorption that causes symptoms. Allergy should be used when the immune system is involved. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 14, 2015 Category: Allergy & Immunology Source Type: research
Urticaria as initial finding of a patient with carcinoid tumor
Conclusion
This patient, whose principal symptoms were anemia, urticaria and angioedema, was found to have atypical carcinoid syndrome, with tumors located in the stomach. Allergists, immunologists, internists and primary care physicians should consider the possibility of neuroendocrine malignancies, specifically type I carcinoid tumors, when evaluating patients with urticaria, and consider screening patients with chronic urticaria for elevated anti-parietal cell antibody levels. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 10, 2015 Category: Allergy & Immunology Source Type: research
Clinical phenotype and allergen sensitization in the first 2 years as predictors of atopic disorders at age 5 years
Conclusion
In this Asian birth cohort, the clinical phenotype (eczema and wheeze) with or without concomitant allergen sensitization in the first 2 years of life were strong predictors of atopic disorders at 5 years. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 2, 2015 Category: Allergy & Immunology Source Type: research
Risk multipliers for severe food anaphylaxis
Abstract
Anaphylaxis is a severe, life threatening allergic reaction. In most fatal cases of food anaphylaxis, the fatality is not due merely to a simple, linear relationship between the allergen and exposure in a sensitized individual. Compounding factors such as the allergic disease burden—particularly the presence of asthma; comprehension of the potential severity of an event, training in the appropriate use of epinephrine, and emerging metabolic factors should be considered when assessing risk and establishing management strategies. This paper reviews the factors that contribute to the risk of sev...
Source: World Allergy Organization Journal - November 24, 2015 Category: Allergy & Immunology Source Type: research
Allergen Immunotherapy (AIT): a prototype of Precision Medicine
Abstract
Precision medicine is a medical model aiming to deliver customised healthcare - with medical decisions, practices, and/or products tailored to the individual patient informed but not directed by guidelines. Allergen immunotherapy has unique immunological rationale, since the approach is tailored to the specific IgE spectrum of an individual and modifies the natural course of the disease as it has a persistent efficacy after completion of treatment. In this perspective Allergen Immunotherapy - AIT has to be presently considered a prototype of Precision Medicine.
Precise infor...
Source: World Allergy Organization Journal - November 10, 2015 Category: Allergy & Immunology Source Type: research
2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
Abstract
The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized. Advances in epidemiology, diagnosis, and management in heal...
Source: World Allergy Organization Journal - October 28, 2015 Category: Allergy & Immunology Source Type: research
Higher cord blood 25-hydroxyvitamin D concentrations reduce the risk of early childhood eczema: in children with a family history of allergic disease
Conclusion
In children with a family history of allergic disease, a higher cord blood 25(OH)D concentration appears to be associated with reduced risk of eczema in early childhood.
Trial registration
Australian New Zealand Clinical Trials Registry ACTRN12610000735055 (DOMInO trial: ACTRN12605000569606). (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 6, 2015 Category: Allergy & Immunology Source Type: research
Allergen immunotherapy on the way to product-based evaluation—a WAO statement
Abstract
Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions (“class effects”) on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and ...
Source: World Allergy Organization Journal - September 16, 2015 Category: Allergy & Immunology Source Type: research
Establishing the relationship of inhaler satisfaction, treatment adherence, and patient outcomes: a prospective, real-world, cross-sectional survey of US adult asthma patients and physicians
Conclusions
Higher patient satisfaction with their asthma drug delivery inhaler device is a significant predictor of more favorable clinical outcomes while allergic rhinitis and smoking history were negatively associated with optimal control of asthma. These findings provide clinicians with opportunities to improve patients’ clinical outcomes by tailoring choice of inhaler device therapy and providing education about the correct way to use the device to ensure optimal outcomes. Patients will likely benefit from medical therapy to manage comorbid allergic rhinitis and smoking cessation interventions....
Source: World Allergy Organization Journal - September 10, 2015 Category: Allergy & Immunology Source Type: research
Caution: Reptile pets shuttle grasshopper allergy and asthma into homes
Abstract
The numbers of reptiles in homes has at least doubled in the last decade in Europe and the USA. Reptile purchases are increasingly triggered by the attempt to avoid potentially allergenic fur pets like dogs and cats. Consequently, reptiles are today regarded as surrogate pets initiating a closer relationship with the owner than ever previously observed. Reptile pets are mostly fed with insects, especially grasshoppers and/or locusts, which are sources for aggressive airborne allergens, best known from occupational insect breeder allergies. Exposure in homes thus introduces a new form of domesti...
Source: World Allergy Organization Journal - August 17, 2015 Category: Allergy & Immunology Source Type: research
