Anaphylaxis in a 4-year-old male caused by contact with grasses: a case report
ConclusionsThe case reported here is particularly interesting because, to the best of our knowledge, anaphylaxis due to pollen exposure in children aged<4 years has not been reported before. We strongly encourage all physicians searching for the cause of acute urticaria (allergists, dermatologists, primary-care physicians) to consider the possibility of pollen allergy, and to screen these patients for pollen sensitization. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 18, 2017 Category: Allergy & Immunology Source Type: research
Erratum to: Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 10, 2017 Category: Allergy & Immunology Source Type: research
Establishing the prevalence of low vitamin D in non-immunoglobulin-E mediated gastrointestinal food allergic children in a tertiary centre
ConclusionsChildren with non-IgE mediated gastrointestinal food allergy are at risk of vitamin D insufficiency and deficiency. Further prospective studies need to be performed in all children with non-IgE mediated gastrointestinal food allergies.Trial registrationThe study was registered with the GOSH Research& Development department as a retrospective case note review. The Health Research Authority confirmed that NHS Research and Ethics Committee approval was not required; thus there is no trial registration number. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 10, 2017 Category: Allergy & Immunology Source Type: research
Is allergic sensitization relevant in severe asthma? Which allergens may be culprits?
AbstractSevere asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the results, molds, pet dander, cockroach and ragweed were more frequently responsible for severe asthma. Thunderstorm asthma, in addition, represents a special association between allergic sensitization and an external climatic factor. A detailed knowledge of the most harmful allergens is mandatory for an appropriate diagnostic and...
Source: World Allergy Organization Journal - January 5, 2017 Category: Allergy & Immunology Source Type: research
Is allergic sensitization relevant in severe asthma? Which allergens may be culprit?
AbstractSevere asthma is a major health concern. The allergic (IgE-mediated) form of asthma is well known from a pathogenic viewpoint. We searched the available literature to identify which allergens are most frequently associated with severe, refractory or life threatening asthma. According to the results, molds, pet dander, cockroach and ragweed were more frequently responsible for severe asthma. Thunderstorm asthma, in addition, represents a special association between allergic sensitization and an external climatic factor. A detailed knowledge of the most harmful allergens is mandatory for an appropriate diagnostic and...
Source: World Allergy Organization Journal - January 5, 2017 Category: Allergy & Immunology Source Type: research
Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases –sponsored expert panel
ConclusionsGuidelines have been developed for early introduction of peanut-containing foods into the diets of infants at various risk levels for peanut allergy. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - January 5, 2017 Category: Allergy & Immunology Source Type: research
Fatal asthma; is it still an epidemic?
ConclusionsAsthma mortality still represents a critical issue in the management of the disease, particularly in youngsters. Once more the inadequate treatment and the lack of adherence seem to be not only related to the uncontrolled asthma but also to asthma mortality. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 13, 2016 Category: Allergy & Immunology Source Type: research
Local allergic rhinitis: entopy or spontaneous response?
ConclusionIt can be hypothesized that the nasal IgE production represents a form of spontaneous immune response. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - December 5, 2016 Category: Allergy & Immunology Source Type: research
Asthma heterogeneity and severity
AbstractAsthma is a common, chronic inflammatory airways disease characterized by a clinical syndrome of bronchial hyperresponsiveness, inflammation, and reversible airflow obstruction. Individuals with asthma can vary widely in clinical presentation, severity, and pathobiology. The incident factors, pathogenesis, prognosis, and treatment of asthma remain incompletely understood. Utilizing measurable characteristics of asthmatic patients, including demographic, physiologic, and biologic markers, can however identify meaningful phenotypic categories in asthma. Identification of these phenotypes may help improve precision th...
Source: World Allergy Organization Journal - November 28, 2016 Category: Allergy & Immunology Source Type: research
Therapeutic interventions in severe asthma
AbstractThe present paper addresses severe asthma which is limited to 5-10% of the overall population of asthmatics. However, it accounts for 50% or more of socials costs of the disease, as it is responsible for hospitalizations and Emergency Department accesses as well as expensive treatments.The recent identification of different endotypes of asthma, based on the inflammatory pattern, has led to the development of tailored treatments that target different inflammatory mediators. These are major achievements in the perspective of Precision Medicine: a leading approach to the modern treatment strategy.Omalizumab, an anti-I...
Source: World Allergy Organization Journal - November 27, 2016 Category: Allergy & Immunology Source Type: research
Omalizumab for chronic urticaria in Latin America
ConclusionOmalizumab is an effective treatment for patients with CU. It is necessary to conduct some future investigations where we can establish if 150 mg could be an option in developing countries. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - November 22, 2016 Category: Allergy & Immunology Source Type: research
Cow ’s milk allergy: towards an update of DRACMA guidelines
ConclusionsEvidence-based diagnostic criteria should be identified for non-IgE-mediated CMA. Debate is ongoing about the best substitute for infants with CMA. In particular, Hydrolyzed Rice Formulae have been widely assessed in the last six years. In the substitute choice, clinicians should be aware of recent studies that can modify the interpretation of the current recommendations. New systematic reviews and metanalyses are needed to confirm or modify the current DRACMA recommendations. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - November 14, 2016 Category: Allergy & Immunology Source Type: research
Effects of poor hygiene on cytokine phenotypes in children in the tropics
We describe immune phenotypes (innate and adaptive cytokines) according to environmental exposure using latent class analysis. A total of 310 schoolchildren living in Ecuador were assayed for spontaneous cytokine production as well as mitogen (SEB)-stimulated cytokines in whole blood cultures. We collected data on environmental exposures by questionnaire and on intestinal parasites by examination of stool samples. Latent class analysis (LCA) was used to group children according to their innate (IL-6, IL-8, IL-10 and TNF- α) and adaptive (IL-5, IL-13, IL-17, IFN-γ and IL-10) cytokine profile. We also conducted multiple-gr...
Source: World Allergy Organization Journal - November 2, 2016 Category: Allergy & Immunology Source Type: research
Erratum to: Debates in allergy medicine: specific immunotherapy efficiency in children with atopic dermatitis
(Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - November 1, 2016 Category: Allergy & Immunology Source Type: research
Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA 2 LEN)
This article is being co-published inAsthma Research and Practice and theWorld Allergy Organization Journal. (Source: World Allergy Organization Journal)
Source: World Allergy Organization Journal - October 27, 2016 Category: Allergy & Immunology Source Type: research
