Urologic Oncology: Seminars and Original Investigations This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Predictive role of changes in the tumor burden and International Metastatic Renal Cell Carcinoma Database Consortium class during active surveillance for metastatic renal cell carcinoma
Renal cell carcinoma (RCC) occurs with synchronous metastases at diagnosis in about 25% to 30% of cases. Furthermore, about another 30% of patients radically treated for localized disease will develop metastases during their lifetime [1]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - October 6, 2018 Category: Urology & Nephrology Authors: Davide Bimbatti, Chiara Ciccarese, Emanuela Fantinel, Teodoro Sava, Francesco Massari, Iolanda Bisogno, Mario Romano, Antonio Porcaro, Matteo Brunelli, Guido Martignoni, Renzo Mazzarotto, Walter Artibani, Giampaolo Tortora, Roberto Iacovelli Source Type: research

A novel preoperative model to predict 90-day surgical mortality in patients considered for renal cell carcinoma surgery
Kidney cancer is the 8th leading cancer diagnosis in the United States with an estimated 63,990 of new cases resulting in 14,400 deaths based on 2016 data [1]. In contrast to many of the other most commonly diagnosed malignancies, the incidence of kidney cancer has risen over the last few decades in men and women of every racial and ethnic group [2]. The rise in incidence of kidney cancer has coincided with a downward drift stage migration likely secondary to the more frequent diagnosis of small, incidental renal masses on cross-sectional imaging [3 –6]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - October 1, 2018 Category: Urology & Nephrology Authors: Adam C. Calaway, M. Francesca Monn, Clinton D. Bahler, Clint Cary, Ronald S. Boris Source Type: research

Editorial Board
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - October 1, 2018 Category: Urology & Nephrology Source Type: research

Table of Contents
(Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - October 1, 2018 Category: Urology & Nephrology Source Type: research

Prediction of acute kidney injury after radical cystectomy and urinary diversion
The recent article by Furrer et al. [1] assessing theincidence and perioperative risk factors of early postoperative acute kidney injury (AKI) in 912 patientsundergoing radical cystectomy and urinary diversion was of great interest to us. By multiple logistic regression analysis, they showed that prolonged duration of surgery (>400 minutes) was a risk factor identified for postoperative AKI and further independent predictors of postoperative AKI were male sex, alow preoperative plasma creatinine, obesity, and intraoperative blood loss. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 30, 2018 Category: Urology & Nephrology Authors: Liu-Jia-Zi Shao, Fu-Shan Xue, Rui-Juan Guo, Li Zheng Tags: Letter to Editor Source Type: research

Tumor –parenchyma interface and long-term oncologic outcomes after robotic tumor enucleation for sporadic renal cell carcinoma
Current guidelines recommend prioritizing partial nephrectomy (PN) for the treatment of localized renal masses when surgery is indicated [1, 2]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 27, 2018 Category: Urology & Nephrology Authors: Andrea Minervini, Riccardo Campi, Fabrizio Di Maida, Andrea Mari, Ilaria Montagnani, Riccardo Tellini, Agostino Tuccio, Giampaolo Siena, Gianni Vittori, Alberto Lapini, Maria Rosaria Raspollini, Marco Carini Source Type: research

Molecular carcinogenesis in equine penile cancer: A potential animal model for human penile cancer
Human penile cancer is a rare disease in developed countries with an incidence rate of around 1 per 100,000 [1]. In contrast, it is more common in developing countries accounting for up to 10% to 17% of cancer in males with an incidence that reaches 4 per 100,000 [1,2]. Squamous cell carcinoma (SCC) is the predominant cancer type and accounts for over 95% of penile cancer cases [3 –5]. The main treatment for advanced tumors is phalectomy and, when inguinal lymph node metastasis is present, bilateral inguinal lymphadenectomy is also performed. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 27, 2018 Category: Urology & Nephrology Authors: Alejandro Su árez-Bonnet, Claire Willis, Rachel Pittaway, Ken Smith, Tim Mair, Simon L. Priestnall Tags: Original Article Source Type: research

Combining anticancer drugs with osteoprotective agents in prostate cancer —A contemporary update
Treatment of metastatic hormone-sensitive (mHSPC) and castration-resistant prostate cancer (mCRPC) is a multimodal and interdisciplinary process that frequently affects an elderly and frail population. In these patients, changes in bone metabolism can imply a significant impact on all-cause morbidity as well as cancer-related outcomes. Uniquely, these changes can rely on metastatic bone disease itself, but also on treatment-related changes in bone mineral density that are inherent to long-term androgen deprivation therapy (ADT). (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 26, 2018 Category: Urology & Nephrology Authors: Igor Tsaur, Isabel Heidegger, Alexander Kretschmer, Hendrik Borgmann, Cristian Mirvald, Giorgio Gandaglia, Alberto Briganti, Roderick van den Bergh, Derya Tilki, Piet Ost, Guillaume Ploussard, Cristian Surcel, On behalf of the EAU-YAU Prostate Cancer Work Tags: Review article Source Type: research

The impact of age at the time of radiotherapy for localized prostate cancer on the development of second primary malignancies
Radical prostatectomy (RP) and radiotherapy (RT) represent the main treatment modalities for localized prostate cancer (CaP) [1]. RT is also used in the adjuvant setting for patients with pT3 CaP or positive surgical margins, and as salvage treatment for biochemical failure after RP. As treatments become more effective, the increase in survivorship has led to the observation of second primary malignancies (SPMs) in cancer survivors. Radiation is believed to contribute to development of SPMs, and studies have shown relationships between radiation, urothelial dysplasia, and DNA damage [2,3]. (Source: Urologic Oncology: Semin...
Source: Urologic Oncology: Seminars and Original Investigations - September 21, 2018 Category: Urology & Nephrology Authors: Ross E. Krasnow, Dayron Rodr íguez, Ramzy T. Nagle, Matthew Mossanen, Adam S. Kibel, Steven L. Chang Source Type: research

Malignant testicular germ cell tumors in children and adolescents: The AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) protocol
Testicular germ cell tumors (TGCT) are rare in children, and histologically and genetically similar to extragonadal tumors [1], whereas in adolescents they reveal genetic and clinical patterns similar to the disease in adults. These differences have led to TGCT being classified as type I for children with yolk sac tumor (YST) and/or teratoma (T) or type II for adolescents and young men with other, pure or mixed, sub entities [2]. In a previous Italian study [3], 36 TGCT patients ( ≤16 years old) underwent surgery, with or without radiotherapy and carboplatin-based chemotherapy (CT). (Source: Urologic Oncology: Seminars a...
Source: Urologic Oncology: Seminars and Original Investigations - September 21, 2018 Category: Urology & Nephrology Authors: Monica Terenziani, Maria D. De Pasquale, Gianni Bisogno, Davide Biasoni, Renata Boldrini, Paola Collini, Massimo Conte, Patrizia Dall'Igna, Alessandro Inserra, Fraia Melchionda, Fortunato Siracusa, Filippo Spreafico, Francesco Barretta, Paolo D'Angelo Tags: Original article Source Type: research

Seniority of primary care physicians is associated with a decrease in PSA ordering habits in the years surrounding the United States Preventative Services Task Force recommendation against PSA screening
Screening practices in primary care environments have changed dramatically in the past 5 decades. Currently, primary care providers (PCPs) are advised by various regulatory and specialty groups to screen for patient issues from colon cancer to smoking status to safety in the home [1 –5] with discordance between specialty advisory groups on many issues. The most recent summary of preventative screening recommendations from the American Academy of Family Physicians advised on screening practices for 134 different diseases and adverse social situations [5]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 18, 2018 Category: Urology & Nephrology Authors: Ryan Hutchinson, Nirmish Singla, Abdulhadi Akhtar, Justin Haridas, Deepa Bhat, Claus Roehrborn, Yair Lotan Tags: Original article Source Type: research

Prostate cancer tissues with positive TMPRSS2-ERG-gene-fusion status may display enhanced nerve density
Innervation of prostate cancer (CaP) tissue favors tumor progression and metastasis but the regulation of innervation in CaP is unclear. The oncogenic transcription factor ERG is commonly induced by a typical TMPRSS2-ERG (TE) gene fusion in CaP and may affect innervation. Here, we analyzed whether nerve density of CaP tissue is related to TE status or perineural infiltration status of CaP tissue. In parallel, we measured several members of the neuropilin/plexin/semaphorin family (NRP, PLXN, and SEMA) as possible targets mediating innervation. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 18, 2018 Category: Urology & Nephrology Authors: J örg Hänze, Peter Rexin, Peter Jakubowski, Henner Schreiber, Hendrik Heers, Susanne Lingelbach, Ralf Kinscherf, Eberhard Weihe, Rainer Hofmann, Axel Hegele Tags: Seminars article Source Type: research

Will the kidney function be reduced in patients with renal cell carcinoma following laparoscopic partial nephrectomy? Baseline eGFR, warm ischemia time, and RENAL nephrometry score could tell
The incidence of small renal cell carcinoma (RCC) is increasing and cases are frequently often detected incidentally due to the widespread use of abdominal imaging technologies [1]. For small local cortical renal masses, partial nephrectomy (PN) is the preferred surgical treatment, as it provides an equivalent oncological outcome and superior renal function preservation compared to radical nephrectomy (RN) [2,3]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 18, 2018 Category: Urology & Nephrology Authors: Zhixian Wang, Chang Liu, Ruibao Chen, Shiliang Liu, Chunxiang Feng, Kai Yu, Xiaoyong Zeng Tags: Original article Source Type: research

Self-reported Black race predicts significant prostate cancer independent of clinical setting and clinical and socioeconomic risk factors
In 2017, 161,360 estimated cases of prostate cancer (CaP) were diagnosed in the United States [1]. Men of high genetic West African ancestry (WAA) face disparities in CaP incidence worldwide. As a corollary, several studies have demonstrated that US Black men have increased risk of CaP diagnosis on prostate biopsy relative to White men [2]. It is unclear whether this is predominantly attributable to socioeconomic or biologic factors [3,4]. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 17, 2018 Category: Urology & Nephrology Authors: Oluwarotimi S. Nettey, Austin J. Walker, Mary Kate Keeter, Ashima Singal, Aishwarya Nugooru, Iman K. Martin, Maria Ruden, Pooja Gogana, Michael A. Dixon, Tijani Osuma, Courtney M.P. Hollowell, Roohollah Sharifi, Marin Sekosan, Ximing Yang, William J. Cata Tags: Original article Source Type: research

Immediate intravesical chemotherapy for low-grade bladder tumors in California: An underutilized practice and its impact on recurrence
The delivery of quality care in cancer in the United States has been described as being in a state of crisis [1], while the cost of health care continues to grow to unsustainable levels [2]. Furthermore, the burden of bladder cancer in the United States is significant, with over 79,030 new cases estimated in 2017, and it remains the most prevalent malignancy of the urinary system with an estimated prevalence in the United States of 696,440 in 2014 [3]. The majority of incident cases represent nonmuscle invasive and low-grade disease. (Source: Urologic Oncology: Seminars and Original Investigations)
Source: Urologic Oncology: Seminars and Original Investigations - September 17, 2018 Category: Urology & Nephrology Authors: Stanley A. Yap, Ann Brunson, Neil Pugashetti, Rosemary D. Cress, M.P.H., Theresa H.M. Keegan, Ralph deVere White, Ted Wun Tags: Original article Source Type: research